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1.发明公开BISARYLCARBINOL CINNAMIC ACIDS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS 失效上抑制LEUKOTRIENER生物合成BISARYLCARBINOL肉桂酸衍生物
公开(公告)号：EP0788490A1
公开(公告)日：1997-08-13
申请号：EP95944790.0
申请日：1995-10-25
IPC分类号： C07D233 , A61K31 , A61P11 , A61P27 , A61P29 , A61P43 , C07C59 , C07C205 , C07C317 , C07C323 , C07D207 , C07D213 , C07D277 , C07D307 , C07D333 , C07D405 , C07D417 , C07D521
CPC分类号： C07D207/337 , C07C317/46 , C07C323/62 , C07D213/55 , C07D213/61 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/30 , C07D307/54 , C07D405/12 , C07D417/12
摘要： Compounds having the formula (I): R?1R2C(OR3)-Ar1-X-Ar2-C(Ar3¿)=CHCO¿2?H are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
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2.发明公开BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS 失效BISARYLCARBINOL衍生物用于抑制LEUKOTRIENER生物合成
公开(公告)号：EP0788497A1
公开(公告)日：1997-08-13
申请号：EP95944792.0
申请日：1995-10-25
发明人： DELORME, Daniel , DUCHARME, Yves , FRIESEN, Richard , GRIMM, Erich, L. , LEPINE, Carole , DUBE, Daniel
IPC分类号： A61K31 , A61P25 , A61P29 , A61P43 , C07D277 , C07D311 , C07D405 , C07D407 , C07D409 , C07D417 , C07D521
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D311/16 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/04 , C07D409/04 , C07D417/04 , C07D417/12 , C07D417/14 , Y10S514/826
摘要： Compounds having the formula (I): R?1R2C(OR3)-Ar1-X-Ar2-Ar3¿ are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
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