公开(公告)号：EP0673366B1

公开(公告)日：1998-10-14

申请号：EP94901716.4

申请日：1993-12-13

申请人： MERCK FROSST CANADA INC.

发明人： FORD-HUTCHINSON, Anthony, W. ,  KENNEDY, Brian, P. ,  PRASIT, Petpiboon ,  VICKERS, Philip, J. ,  LU, Chun-Sing ,  BLACK, Cameron ,  GUAY, Daniel ,  LAU, Cheuk, Kun ,  ROY, Patrick

IPC分类号： C07C323/49 ,  C07C311/24 ,  C07C323/20 ,  A61K31/18

CPC分类号： C07C311/08 ,  C07C323/49 ,  C07C2602/08

公开(公告)号：EP0639181A1

公开(公告)日：1995-02-22

申请号：EP93907720.0

申请日：1993-04-02

申请人： MERCK FROSST CANADA INC.

发明人： ZAMBONI, Robert ,  GUAY, Daniel ,  GAUTHIER, Jacques-Yves

IPC分类号： C07D213 ,  A61K31 ,  A61P11 ,  A61P43 ,  C07D215 ,  C07D401 ,  C07D405 ,  C07D409 ,  C07D413 ,  C07D417

CPC分类号： C07D401/12 ,  A61K31/41 ,  A61K31/44 ,  C07D213/32 ,  C07D213/61 ,  C07D213/65 ,  C07D215/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  C07D417/04

摘要： Compounds having formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

公开(公告)号：EP0699188A1

公开(公告)日：1996-03-06

申请号：EP94916105.0

申请日：1994-05-19

申请人： MERCK FROSST CANADA INC.

发明人： LABELLE, Marc ,  LEBLANC, Yves ,  BELLEY, Michel ,  GRIMM, Erich, L. ,  GUAY, Daniel ,  XIANG, Yi, Bin

IPC分类号： C07D215 ,  A61K31 ,  A61P11 ,  A61P29 ,  A61P37 ,  A61P43 ,  C07D401 ,  C07D405 ,  C07D417

CPC分类号： C07D215/18

摘要： Compounds having formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

公开(公告)号：EP0882015A1

公开(公告)日：1998-12-09

申请号：EP97900915.0

申请日：1997-01-29

申请人： MERCK FROSST CANADA INC.

发明人： BLACK, Cameron ,  GIRARD, Mario ,  GUAY, Daniel ,  WANG, Zhaoyin

IPC分类号： C07D295 ,  A61K31 ,  A61P29 ,  A61P43 ,  C07C311 ,  C07C317

CPC分类号： C07D295/185 ,  C07C311/16 ,  C07C311/29 ,  C07C317/22 ,  C07C317/24 ,  C07C317/44

摘要： The invention encompasses the novel compound of Formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).

公开(公告)号：EP0673366A1

公开(公告)日：1995-09-27

申请号：EP94901716.0

申请日：1993-12-13

申请人： MERCK FROSST CANADA INC.

发明人： FORD-HUTCHINSON, Anthony, W. ,  KENNEDY, Brian, P. ,  PRASIT, Petpiboon ,  VICKERS, Philip, J. ,  LU, Chun-Sing ,  BLACK, Cameron ,  GUAY, Daniel ,  LAU, Cheuk, Kun ,  ROY, Patrick

IPC分类号： A61K45 ,  A61K31 ,  A61P29 ,  A61P43 ,  C07C311 ,  C07C323

CPC分类号： C07C311/08 ,  C07C323/49 ,  C07C2602/08

摘要： The compound of formula (I') and pharmaceutically acceptable salts therof have been found to be useful in the treatment of inflammation particularly cyclooxygenase mediated diseases including pain, fever and inflammation of a variety of conditions including rheumatic fever, symptoms associated with influenza or other viral infections, common cold, low back and neck pain, dysmenorrhea, headache, toothache, sprains and strains, myositis, neuralgia, synovitis, arthritis, including rheumatoid arthritis degenerative joint diseases (osteoarthritis), gout and ankylosing spondylitis, bursitis, burns, injuries.

摘要翻译： 公开了式I化合物及其药学上可接受的盐在环氧合酶-2介导的疾病的治疗中的用途。 I

公开(公告)号：EP1177175A2

公开(公告)日：2002-02-06

申请号：EP00922400.7

申请日：2000-05-03

申请人： MERCK FROSST CANADA INC.

发明人： COTE, Bernard ,  FRIESEN, Richard ,  FRENETTE, Richard ,  GIRARD, Mario ,  GIRARD, Yves ,  GODBOUT, Cedrickx ,  GUAY, Daniel ,  HAMEL, Pierre ,  BLOUIN, Marc ,  DUCHARME, Yves ,  PRESCOTT, Sylvie

IPC分类号： C07D213/89 ,  C07D213/74 ,  C07D417/14 ,  C07D401/14 ,  C07D409/14 ,  C07D213/79 ,  C07D213/76 ,  C07D405/14 ,  A61K31/4427 ,  A61P11/00

CPC分类号： C07D213/74 ,  C07D213/76 ,  C07D213/79 ,  C07D213/89 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

摘要： The invention encompasses the novel compound of Formula (I) useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE 4) or a pharmaceutically acceptable salt or hydrate thereof. The invention also encompasses pharmaceutical compositions and methods for treatment.

公开(公告)号：EP0889878A1

公开(公告)日：1999-01-13

申请号：EP97908099.0

申请日：1997-03-25

申请人： MERCK FROSST CANADA INC.

发明人： DUBE, Daniel ,  FORTIN, Rejean ,  FRENETTE, Richard ,  FRIESEN, Richard ,  GUAY, Daniel ,  PRESCOTT, Sylvie

IPC分类号： C07D317 ,  A61K31 ,  A61P29 ,  A61P31 ,  A61P35 ,  A61P43 ,  C07C311 ,  C07C317 ,  C07C321 ,  C07C323 ,  C07D213 ,  C07D333 ,  C07D339

CPC分类号： C07C311/16 ,  C07C317/14 ,  C07C317/22 ,  C07C317/24 ,  C07C317/32 ,  C07C317/44 ,  C07C321/28 ,  C07C323/22 ,  C07C323/62 ,  C07D333/22

摘要： The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).

摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式（I）化合物。 本发明还包括用于治疗包含式（I）化合物的环加氧酶-2介导的疾病的某些药物组合物。

公开(公告)号：EP1272488A2

公开(公告)日：2003-01-08

申请号：EP01914905.3

申请日：2001-03-19

申请人： MERCK FROSST CANADA INC.

发明人： FRIESEN, Richard ,  DUCHARME, Yves ,  COTE, Bernard ,  BLOUIN, Marc ,  MARTINS, Evelyn ,  GUAY, Daniel ,  HAMEL, Pierre ,  GIRARD, Mario ,  FRENETTE, Richard ,  LALIBERTE, Sebastien

IPC分类号： C07D417/08 ,  A61P37/00 ,  C07D417/06 ,  C07D417/14 ,  A61K31/427

CPC分类号： C07D417/06

摘要： Novel ethanes substituted with i) a phenyl, ii) a thiazole, and iii) a pyridyl moiety are PDE4 inhibitors.

公开(公告)号：EP0873311A1

公开(公告)日：1998-10-28

申请号：EP96940967.0

申请日：1996-12-11

申请人： MERCK FROSST CANADA INC.

发明人： GUAY, Daniel ,  GIRARD, Yves ,  DUCHARME, Yves ,  BLOUIN, Marc ,  HAMEL, Pierre ,  GIRARD, Mario

IPC分类号： A61K31 ,  A61P11 ,  A61P43 ,  C07D213

CPC分类号： C07D213/30

摘要： The invention encompasses the novel compound of formula (I), useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula (I).

公开(公告)号：EP0873310A1

公开(公告)日：1998-10-28

申请号：EP96940966.0

申请日：1996-12-11

申请人： MERCK FROSST CANADA INC.

发明人： GUAY, Daniel ,  GIRARD, Yves ,  DUCHARME, Yves

IPC分类号： C07D213 ,  C07D401

摘要： The invention encompasses the novel compound of formula (I) useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of formula (I).