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公开(公告)号：EP1581215B1
公开(公告)日：2010-02-17
申请号：EP03789341.9
申请日：2003-12-18
申请人： Merck Patent GmbH
发明人： AUTIER, Valérie , ARBELLOT DE VACQUEUR, Annick , MOINET, Gérard , MARAIS, Dominique , KARGAR, Catherine , KERGOAT, Micheline
IPC分类号： A61K31/194 , A61K31/235 , A61P3/10 , C07C321/26
CPC分类号： A61K45/06 , A61K31/00 , A61K31/06 , A61K31/19 , A61K31/192 , A61K31/194 , A61K31/216 , A61K31/22 , A61K31/235 , A61K31/426 , A61K31/55 , A61K2300/00
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公开(公告)号：EP1581215A1
公开(公告)日：2005-10-05
申请号：EP03789341.9
申请日：2003-12-18
申请人： Merck Patent GmbH
发明人： AUTIER, Valérie , ARBELLOT DE VACQUEUR, Annick , MOINET, Gérard , MARAIS, Dominique , KARGAR, Catherine , KERGOAT, Micheline
IPC分类号： A61K31/426 , A61K31/194 , A61K31/235 , A61P3/10 , C07C321/26
CPC分类号： A61K45/06 , A61K31/00 , A61K31/06 , A61K31/19 , A61K31/192 , A61K31/194 , A61K31/216 , A61K31/22 , A61K31/235 , A61K31/426 , A61K31/55 , A61K2300/00
摘要： The present invention relates to the use of at least one compound with inhibitory activity on kynurenine 3-hydroxylase for the preparation of a medicament for the prevention and/or treatment of diabetes.
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3.发明授权
公开(公告)号：EP1450780B1
公开(公告)日：2007-03-07
申请号：EP02779532.7
申请日：2002-11-06
申请人： Merck Patent GmbH
IPC分类号： A61K31/192 , A61K31/36 , A61K31/341 , A61P29/00 , A61P43/00
CPC分类号： A61K31/36
摘要： The present invention relates to the use of a 4-oxobutanoic acid derivative for the preparation of a pharmaceutical composition for treating inflammation.
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4.发明授权PHARMACEUTICAL COMPOSITION COMPRISING A COMBINATION OF METFORMIN AND A 4-OXOBUTANOIC ACID, AND THE USE THEREOF FOR TREATING DIABETES 有权药物制备含二甲双胍组合以及4-OXOBUTANONSÄURE及其用于治疗糖尿病的
公开(公告)号：EP1448181B1
公开(公告)日：2006-05-31
申请号：EP02787576.4
申请日：2002-11-06
申请人： Merck Patent GmbH
发明人： MOINET, Gérard , MARAIS, Dominique
CPC分类号： A61K31/19 , A61K31/33 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising, as active principles, metformin, optionally in the form of one of its pharmaceutically acceptable salts, and a 4-oxobutanoic acid, in combination with one or more pharmaceutically acceptable excipients. These compositions are particularly suitable for treating non-insulin-dependent diabetes.
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5.发明公开PHARMACEUTICAL COMPOSITION COMPRISING A GLITAZONE AND A 4-OXOBUTANOIC ACID, AND THE USE THEREOF FOR TREATING DIABETES 审中-公开药物组合物含有格列酮和4-氧代，及其用于治疗糖尿病的
公开(公告)号：EP1463503A1
公开(公告)日：2004-10-06
申请号：EP02796640.7
申请日：2002-12-16
申请人： MERCK PATENT GmbH
发明人： MOINET, Gérard , MARAIS, Dominique
IPC分类号： A61K31/425 , A61K31/44 , A61P3/10
CPC分类号： A61K31/425 , A61K31/44 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising, as active principles, a 4-oxobutanoic acid and a glitazone, in combination with one or more pharmaceutically acceptable excipients. These compositions are particularly suitable for treating diabetes.
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6.发明公开ANTIDIABETIC PIPERAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM 审中-公开抗糖尿病哌嗪衍生物，用于生产和含有组合物
公开(公告)号：EP1100790A1
公开(公告)日：2001-05-23
申请号：EP99936561.2
申请日：1999-07-17
申请人： MERCK PATENT GmbH
IPC分类号： C07D295/08 , A61K31/495 , C07D213/72 , C07D239/42 , C07D277/82
CPC分类号： C07D239/42 , C07D213/74 , C07D277/82 , C07D295/088
摘要： The invention relates to novel piperazine derivatives of formula (I) wherein (Z)i, X, N and Ar have the meanings as given in claim 1, and which are of use in the treatment of pathologies associated with insulin-resistance syndrome.
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7.发明公开USE OF AMPK-ACTIVATING IMIDAZOLE DERIVATIVES, PREPARATION PROCESS THEREFOR AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 有权AMPK激活咪唑衍生物，使用过程中其制造和药物组合物含
公开(公告)号：EP2040702A1
公开(公告)日：2009-04-01
申请号：EP07725977.8
申请日：2007-06-12
申请人： Merck Patent GmbH
IPC分类号： A61K31/4164 , C07D233/90 , A61P3/00 , A61P3/10
CPC分类号： C07D233/90
摘要： The invention relates to the use of imidazole derivatives of the formula (I): in which A, R'1, R'2 and R'3 are as defined in the description, as AMPK activators. The invention also relates to processes for the preparation of the said compounds, to their uses for the preparation of medicaments for the treatment of insulin resistance, diabetes and related pathologies, and also obesity, and to the pharmaceutical compositions comprising them. Certain compounds of the formula (I) are novel and, in this respect, also form part of the invention.
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8.发明公开PHARMACEUTICAL COMPOSITION COMPRISING AN ALPHA-GLUCOSIDASE INHIBITOR AND A 4-OXOBUTANOIC ACID, AND THE USE THEREOF FOR TREATING DIABETES 审中-公开药物组合物含有α-葡萄糖苷酶抑制剂和4-0X0BUTANSÄURE，他们使用的治疗糖尿病
公开(公告)号：EP1458412A1
公开(公告)日：2004-09-22
申请号：EP02792933.0
申请日：2002-12-07
申请人： MERCK PATENT GmbH
发明人： MOINET, Gérard , MARAIS, Dominique
IPC分类号： A61K45/06 , A61K31/445 , A61K31/70 , A61P3/10
CPC分类号： A61K45/06 , A61K31/445 , A61K31/70 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising, as active principles, a 4-oxobutanoic acid and an α-glucosidase inhibitor, in combination with one or more pharmaceutically acceptable excipients. These compositions are particularly suitable for treating diabetes.
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9.发明公开PHARMACEUTICAL COMPOSITION COMPRISING A COMBINATION OF METFORMIN AND A 4-OXOBUTANOIC ACID, AND THE USE THEREOF FOR TREATING DIABETES 有权药物组合物的二甲双胍的组合，并且A 4-OXOBUTANONSÄURE及其用于治疗糖尿病的
公开(公告)号：EP1448181A1
公开(公告)日：2004-08-25
申请号：EP02787576.4
申请日：2002-11-06
申请人： MERCK PATENT GmbH
发明人： MOINET, Gérard , MARAIS, Dominique
CPC分类号： A61K31/19 , A61K31/33 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising, as active principles, metformin, optionally in the form of one of its pharmaceutically acceptable salts, and a 4-oxobutanoic acid, in combination with one or more pharmaceutically acceptable excipients. These compositions are particularly suitable for treating non-insulin-dependent diabetes.
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10.发明授权USE OF AMPK-ACTIVATING IMIDAZOLE DERIVATIVES, PREPARATION PROCESS THEREFOR AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 有权AMPK激活咪唑衍生物，使用过程中其制造和药物组合物含
公开(公告)号：EP2040702B1
公开(公告)日：2011-07-27
申请号：EP07725977.8
申请日：2007-06-12
申请人： Merck Patent GmbH
IPC分类号： A61K31/4164 , C07D233/90 , A61P3/00 , A61P3/10
CPC分类号： C07D233/90
摘要： The invention relates to the use of imidazole derivatives of the formula (I): in which A, R'1, R'2 and R'3 are as defined in the description, as AMPK activators. The invention also relates to processes for the preparation of the said compounds, to their uses for the preparation of medicaments for the treatment of insulin resistance, diabetes and related pathologies, and also obesity, and to the pharmaceutical compositions comprising them. Certain compounds of the formula (I) are novel and, in this respect, also form part of the invention.
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