公开(公告)号：EP3285581A1

公开(公告)日：2018-02-28

申请号：EP16769472

申请日：2016-03-21

申请人： MERCK SHARP & DOHME

发明人： SHEN DONG-MING ,  YANG MENG ,  CRESPO ALEJANDRO ,  WILSON JONATHAN E ,  MCCRACKEN TROY ,  WANG DEPING ,  PARKER DANN ,  GUO ZACK ZHIQIANG

IPC分类号： A01N43/90 ,  A61K31/535

CPC分类号： C07D403/04 ,  C07D401/14 ,  C07D405/14

摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

公开(公告)号：EP3270926A4

公开(公告)日：2018-08-01

申请号：EP16765473

申请日：2016-03-11

申请人： MERCK SHARP & DOHME

发明人： SHEN DONG-MING ,  SINZ CHRISTOPHER J ,  CRESPO ALEJANDRO ,  WILSON JONATHAN E ,  MCCRACKEN TROY ,  XU SHIMIN ,  LI HAITANG

IPC分类号： C07D403/04 ,  A61K31/513 ,  A61P25/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

CPC分类号： C07D498/04 ,  A61P25/00 ,  C07D403/04 ,  C07D471/04 ,  C07D487/04

摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

公开(公告)号：EP2888005A4

公开(公告)日：2016-04-20

申请号：EP13830277

申请日：2013-08-19

申请人： MERCK SHARP & DOHME

发明人： APGAR JAMES M ,  ARASAPPAN ASHOK ,  BIFTU TESFAYE ,  CHEN PING ,  FENG DANQING ,  GUIDRY ERIN ,  HICKS JACQUELINE ,  KEKEC AHMET ,  LEAVITT KENNETH ,  LI BING ,  MCCRACKEN TROY ,  SEBHAT IYASSU ,  QIAN XIAOXIA ,  WEI LAN ,  WILKENING ROBERT ,  WU ZHICAI

IPC分类号： C07D519/00 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/454 ,  A61P3/10

CPC分类号： C07D519/00 ,  A61K31/366 ,  A61K31/397 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61K2300/00

摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.

公开(公告)号：EP2680851A4

公开(公告)日：2015-04-22

申请号：EP12752079

申请日：2012-03-01

申请人： MERCK SHARP & DOHME

发明人： BENNETT CHAD E ,  BURNETT DUANE A ,  LI HONGMEI ,  CHEN YONGGANG ,  MCCRACKEN TROY

IPC分类号： A61K31/519 ,  C07D473/18 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61K31/155 ,  A61K31/427 ,  A61K31/519 ,  A61K31/522 ,  A61K31/64 ,  A61K45/06 ,  C07D473/18 ,  C07D473/28 ,  A61K2300/00