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公开(公告)号：EP2706853A4
公开(公告)日：2014-11-05
申请号：EP12782298
申请日：2012-05-04
申请人： MERCK SHARP & DOHME
发明人： ALTMAN MICHAEL D , CHILDERS KALEEN KONRAD , DI FRANCESCO MARIA EMILIA , ELLIS JOHN MICHAEL , FISCHER CHRISTIAN , GRIMM JONATHAN , HAIDLE ANDREW M , KATTAR SOLOMON D , NORTHRUP ALAN B , OTTE RYAN D , PETROCCHI ALESSIA , SCHELL ADAM J , ZHOU HUA
IPC分类号： A01N43/54 , A61K31/505 , A61K31/506 , A61P11/06 , A61P35/00 , C07D417/12 , C07D417/14
CPC分类号： C07D417/12 , C07D417/14
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2.发明公开2-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS 有权2-吡啶基甲酰胺CONTAINING MILZTYROSINKINASE抑制剂
公开(公告)号：EP2763976A4
公开(公告)日：2015-03-04
申请号：EP12838717
申请日：2012-10-01
申请人： MERCK SHARP & DOHME
发明人： ALTMAN MICHAEL D , BIENSTOCK CORE E , BUTCHER JOHN W , DI FRANCESCO MARIA EMILIA , DONOFRIO ANTHONY , ELLIS JOHN MICHAEL , FISCHER CHRISTIAN , HAIDLE ANDREW M , HAIDLE ANDREW M , JEWELL JAMES P , KNOWLES SANDRA LEE , NORTHRUP ALAN B , OTTE RYAN D , PETERSON SCOTT L , SMITH GRAHAM FRANK
IPC分类号： C07D401/00 , A61P37/00
CPC分类号： A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D213/81 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
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公开(公告)号：EP2707357A4
公开(公告)日：2014-12-03
申请号：EP12782164
申请日：2012-05-04
申请人： MERCK SHARP & DOHME
发明人： ALTMAN MICHAEL D , DI FRANCESCO MARIA EMILIA , HAIDLE ANDREW M , OTTE RYAN D , ELLIS JOHN MICHAEL , CHILDERS KALEEN KONRAD , NORTHRUP ALAN B , YANG LIPING
IPC分类号： C07D417/14 , A61K31/444 , A61P37/00
CPC分类号： C07D417/14
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4.发明公开
公开(公告)号：EP2916837A4
公开(公告)日：2016-07-20
申请号：EP13853278
申请日：2013-11-04
申请人： MERCK SHARP & DOHME
发明人： HAIDLE ANDREW M , CASH BRANDON , JEWELL JAMES P , SPENCER KERRIE , ALTMAN MICHAEL D , OTTE RYAN D , NORTHRUP ALAN B
IPC分类号： C07D213/74 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/5377 , A61P11/00 , A61P19/00 , A61P37/00 , C07D401/14 , C07D405/14 , C07D451/10 , C07H7/06
CPC分类号： C07D213/74 , C07D401/14 , C07D405/14 , C07D451/10 , C07H13/08
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公开(公告)号：EP2166846A4
公开(公告)日：2011-03-23
申请号：EP08768504
申请日：2008-06-16
申请人： MERCK SHARP & DOHME
发明人： ALTMAN MICHAEL , CHRISTOPHER MATTHEW , GRIMM JONATHAN B , HAIDLE ANDREW , KONRAD KALEEN , LIM JONGWON , MACCOSS RACHEL N , MACHACEK MICHELLE , OSIMBONI EKUNDAYO , OTTE RYAN D , SIU TONY , SPENCER KERRIE , TAOKA BRANDON , TEMPEST PAUL , WILSON KEVIN , WOO HYUN CHONG , YOUNG JONATHAN , ZABIEREK ANNA
IPC分类号： C07D409/12 , A61K31/381 , A61K31/44 , A61P35/00 , C07D409/14 , C07D413/14 , C07D417/14 , C07D498/10 , C07F9/6558
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D498/10 , C07F9/65586 , C07F9/65685
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公开(公告)号：EP3116506A4
公开(公告)日：2017-08-02
申请号：EP15761538
申请日：2015-03-09
申请人： MERCK SHARP & DOHME
发明人： ALTMAN MICHAEL D , CASH BRANDON , ELLIS JOHN MICHAEL , MADDESS MATTHEW L , NORTHRUP ALAN B , OTTE RYAN D , SUN BINYUAN
IPC分类号： A61K31/506 , A61K31/497 , A61K31/505 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D491/056
CPC分类号： A61K31/497 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D491/056 , A61K2300/00
摘要： The invention provides certain pyrazine-2-carboxamide compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein A, B, and X are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
摘要翻译： 本发明提供了式（I）的某些吡嗪-2-甲酰胺化合物或其药学上可接受的盐，其中A，B和X如本文所定义。 本发明还提供了包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）介导的疾病或病症的方法。
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7.发明公开THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS 审中-公开THIAZOLSUBSTITUIERTE AMINOHETEROARYLE ALS MILZTYROSINKINASEHEMMER
公开(公告)号：EP3083559A4
公开(公告)日：2017-06-07
申请号：EP14872226
申请日：2014-12-18
发明人： ANDRESEN BRIAN M , ARRINGTON KENNETH L , OTTE RYAN D , ELLIS JOHN MICHAEL , BUTCHER JOHN W , NORTHRUP ALAN B , ROBICHAUD JOEL S , GAUTHIER JACQUES YVES , FOURNIER JEAN-FRANCOIS
IPC分类号： C07D213/72 , A61K31/506 , A61K31/5377 , A61K31/538 , A61P11/06 , A61P11/08 , A61P17/00 , A61P17/06 , A61P19/02 , A61P35/00 , A61P37/08 , C07D417/12 , C07D417/14
CPC分类号： C07D417/14 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D417/12
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8.发明公开
公开(公告)号：EP2934525A4
公开(公告)日：2016-06-08
申请号：EP13864370
申请日：2013-12-19
申请人： MERCK SHARP & DOHME
发明人： ALTMAN MICHAEL D , ANDRESEN BRIAN M , ARRINGTON KENNETH L , CHILDERS KALEEN KONRAD , DI FRANCESCO MARIA EMILIA , ELLIS JOHN MICHAEL , HAIDLE ANDREW M , LIU YUAN , NORTHRUP ALAN , O'BOYLE BRENDAN , OTTE RYAN D , REUTERSHAN MICHAEL H , VITHARANA DILRUKSHI , WOO HYUN CHONG
IPC分类号： A61K31/44 , A61P35/00 , C07D417/14
CPC分类号： C07D417/14 , A61K31/444 , A61K45/06
摘要： The invention provides certain thiazole-substituted aminopyridine compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Cy, and the subscript t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
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公开(公告)号：EP2900665A4
公开(公告)日：2016-03-23
申请号：EP13841430
申请日：2013-09-24
发明人： MACHACEK MICHELLE R , ROMEO ERIC T , KATTAR SOLOMON D , CHRISTOPHER MATTHEW , ALTMAN MICHAEL D , NORTHRUP ALAN B , ELLIS JOHN MICHAEL , BOYLE BRENDAN O' , DONOFRIO ANTHONY , GRIMM JONATHAN , REUTERSHAN MICHAEL H , CHILDERS KALEEN KONRAD , OTTE RYAN D , CASH BRANDON , DUCHARME YVES , HAIDLE ANDREW M , SPENCER KERRIE , VITHARANA DILRUKSHI , WU LINGYUN , ZHANG LI , ZHANG PENG , BEAULIEU CHRISTIAN , GUAY DANIEL
IPC分类号： C07D417/12 , A61K31/506 , A61P11/06 , A61P29/00 , A61P35/00 , C07D239/50 , C07D417/14
CPC分类号： C07D401/14 , A61K9/0019 , A61K9/0073 , A61K9/0075 , A61K9/10 , A61K9/2027 , A61K9/4858 , C07D239/42 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/04
摘要： Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
摘要翻译： 提供式I的三唑衍生物，其是脾脏酪氨酸激酶和药物组合物的有效抑制剂。 三唑衍生物可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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公开(公告)号：EP2863914A4
公开(公告)日：2015-12-16
申请号：EP13807800
申请日：2013-06-18
发明人： MACHACEK MICHELE R , ALTMAN MICHAEL D , ROMEO ERIC T , WITHARANA DILRUKSHI , CASH BRANDON , SIU TONY , ZHOU HUA , CHRISTOPHER MATTHEW , KATTAR SOLOMON D , HAIDLE ANDREW M , CHILDERS KALEEN KONRAD , MADDESS MATTHEW H , REUTERSHAN MICHAEL H , DUCHARME YVES , GUERIN DAVID J , SPENCER KERRIE , BEAULIEU CHRISTIAN , TRUONG VOUY LINH , GUAY DANIEL , NORTHRUP ALAN B , TAOKA BRANDON M , LIM JONGWON , FISCHER CHRISTIAN , BUTCHER JOHN W , OTTE RYAN D , SUN BINYUAN , ELLIS JOHN MICHAEL
IPC分类号： A61K31/50 , A61K31/501 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04
CPC分类号： C07D471/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
摘要翻译： 本发明提供了式I的新型吡唑衍生物，其是脾脏酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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