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1.发明公开SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS 有权SUBSTITUIERTE PYRIDIN-MILZ-TYROSINKINASEINHIBITOREN
公开(公告)号：EP2863916A4
公开(公告)日：2015-12-16
申请号：EP13807050
申请日：2013-06-17
发明人： HAIDLE ANDREW M , KNOWLES SANDRA LEE , KATTAR SOLOMON D , DESCHENES DENIS , BURCH JASON , ROBICHAUD JOEL , CHRISTOPHER MATTHEW , ALTMAN MICHAEL D , JEWELL JAMES P , NORTHHRUP ALAN B , BLOUIN MARC , ELLIS JOHN MICHAEL , ZHOU HUA , FISCHER CHRISTIAN , SCHELL ADAM J , REUTERSHAN MICHAEL H , TAOKA BRANDON M , DONOFRIO ANTHONY
IPC分类号： C07D401/12 , A61K31/506 , A61P11/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/08 , C07D491/107 , C07D491/113 , C07D498/04
CPC分类号： C07D401/12 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/551 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/08 , C07D491/107 , C07D491/113 , C07D498/04 , A61K2300/00
摘要： The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
摘要翻译： 本发明提供了式（I）的某些取代的吡啶或其药学上可接受的盐，其中R1，R2，R3，R4，Rcy，Cy和t如本文所定义。 本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）激酶介导的疾病或病症的方法。
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公开(公告)号：EP2863913A4
公开(公告)日：2015-12-16
申请号：EP13807108
申请日：2013-06-18
发明人： LIM JONGWON , REUTERSHAN MICHAEL H , ELLIS JOHN MICHAEL , CHILDERS KALEEN KONRAD , DONOFRIO ANTHONY , ALTMAN MICHAEL D , HAIDLE ANDREW M , ZABIEREK ANNA , CHRISTOPHER MATTHEW , GRIMM JONATHAN , BURCH JASON , FRANCESCO MARIA EMILIA DI , PETROCCHI ALESSIA , BEAULIEU CHRISTIAN , TRUONG VOUY LINH , NORTHRUP ALAN B , BLOUIN MARC
IPC分类号： A61K31/50 , A61K31/501 , C07D401/14 , C07D403/12 , C07D403/14
CPC分类号： C07D403/12 , C07D401/14 , C07D403/14
摘要： The present invention provides novel imidazole analogs of Formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
摘要翻译： 本发明提供了式I的新型咪唑类似物，其是脾脏酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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3.发明公开SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS 有权SUBSTITUIERTE PHENYL-MILZ-TYROSINKINASEINHIBITOREN
公开(公告)号：EP2884982A4
公开(公告)日：2016-03-30
申请号：EP13831537
申请日：2013-08-15
发明人： HAIDLE ANDREW M , BURCH JASON , GUAY DANIEL , GAUTHIER JACQUES YVES , ROBICHAUD JOEL , FOURNIER JEAN FRANCOIS , ELLIS JOHN MICHAEL , CHRISTOPHER MATTHEW , KATTAR SOLOMON D , SMITH GRAHAM , NORTHRUP ALAN B
IPC分类号： A61K31/54 , A61K31/505 , A61K31/506
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , A61K45/06 , C07D239/47 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/10
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公开(公告)号：EP2900665A4
公开(公告)日：2016-03-23
申请号：EP13841430
申请日：2013-09-24
发明人： MACHACEK MICHELLE R , ROMEO ERIC T , KATTAR SOLOMON D , CHRISTOPHER MATTHEW , ALTMAN MICHAEL D , NORTHRUP ALAN B , ELLIS JOHN MICHAEL , BOYLE BRENDAN O' , DONOFRIO ANTHONY , GRIMM JONATHAN , REUTERSHAN MICHAEL H , CHILDERS KALEEN KONRAD , OTTE RYAN D , CASH BRANDON , DUCHARME YVES , HAIDLE ANDREW M , SPENCER KERRIE , VITHARANA DILRUKSHI , WU LINGYUN , ZHANG LI , ZHANG PENG , BEAULIEU CHRISTIAN , GUAY DANIEL
IPC分类号： C07D417/12 , A61K31/506 , A61P11/06 , A61P29/00 , A61P35/00 , C07D239/50 , C07D417/14
CPC分类号： C07D401/14 , A61K9/0019 , A61K9/0073 , A61K9/0075 , A61K9/10 , A61K9/2027 , A61K9/4858 , C07D239/42 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/04
摘要： Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
摘要翻译： 提供式I的三唑衍生物，其是脾脏酪氨酸激酶和药物组合物的有效抑制剂。 三唑衍生物可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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公开(公告)号：EP2863914A4
公开(公告)日：2015-12-16
申请号：EP13807800
申请日：2013-06-18
发明人： MACHACEK MICHELE R , ALTMAN MICHAEL D , ROMEO ERIC T , WITHARANA DILRUKSHI , CASH BRANDON , SIU TONY , ZHOU HUA , CHRISTOPHER MATTHEW , KATTAR SOLOMON D , HAIDLE ANDREW M , CHILDERS KALEEN KONRAD , MADDESS MATTHEW H , REUTERSHAN MICHAEL H , DUCHARME YVES , GUERIN DAVID J , SPENCER KERRIE , BEAULIEU CHRISTIAN , TRUONG VOUY LINH , GUAY DANIEL , NORTHRUP ALAN B , TAOKA BRANDON M , LIM JONGWON , FISCHER CHRISTIAN , BUTCHER JOHN W , OTTE RYAN D , SUN BINYUAN , ELLIS JOHN MICHAEL
IPC分类号： A61K31/50 , A61K31/501 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04
CPC分类号： C07D471/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
摘要翻译： 本发明提供了式I的新型吡唑衍生物，其是脾脏酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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公开(公告)号：EP2706852A4
公开(公告)日：2014-11-05
申请号：EP12782391
申请日：2012-05-04
发明人： DESCHENES DENIS , ALTMAN MICHAEL D , ELLIS JOHN MICHAEL , FISCHER CHRISTIAN , HAIDLE ANDREW M , KATTAR SOLOMON D , NORTHRUP ALAN B , SCHELL ADAM J , SMITH GRAHAM F , TAOKA BRANDON M , BIENSTOCK COREY , DI FRANCESCO MARIA EMILIA , DONOFRIO ANTHONY , PETERSON SCOTT , SPENCER KERRIE B , JEWELL JAMES PATRICK , ALI AMJAD , BENNETT DAVID JONATHAN , DANG QUN , WAL JOHN
IPC分类号： A01N43/40 , A61K31/44 , C07D213/04
CPC分类号： C07D401/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04
摘要： The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, or are prodrugs thereof, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis and cancer.
摘要翻译： 本发明提供了式I的新型嘧啶胺，其是脾脏酪氨酸激酶的有效抑制剂，或其前药，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD和类风湿性关节炎和癌症。
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公开(公告)号：EP2706853A4
公开(公告)日：2014-11-05
申请号：EP12782298
申请日：2012-05-04
申请人： MERCK SHARP & DOHME
发明人： ALTMAN MICHAEL D , CHILDERS KALEEN KONRAD , DI FRANCESCO MARIA EMILIA , ELLIS JOHN MICHAEL , FISCHER CHRISTIAN , GRIMM JONATHAN , HAIDLE ANDREW M , KATTAR SOLOMON D , NORTHRUP ALAN B , OTTE RYAN D , PETROCCHI ALESSIA , SCHELL ADAM J , ZHOU HUA
IPC分类号： A01N43/54 , A61K31/505 , A61K31/506 , A61P11/06 , A61P35/00 , C07D417/12 , C07D417/14
CPC分类号： C07D417/12 , C07D417/14
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8.发明公开
公开(公告)号：EP2934525A4
公开(公告)日：2016-06-08
申请号：EP13864370
申请日：2013-12-19
申请人： MERCK SHARP & DOHME
发明人： ALTMAN MICHAEL D , ANDRESEN BRIAN M , ARRINGTON KENNETH L , CHILDERS KALEEN KONRAD , DI FRANCESCO MARIA EMILIA , ELLIS JOHN MICHAEL , HAIDLE ANDREW M , LIU YUAN , NORTHRUP ALAN , O'BOYLE BRENDAN , OTTE RYAN D , REUTERSHAN MICHAEL H , VITHARANA DILRUKSHI , WOO HYUN CHONG
IPC分类号： A61K31/44 , A61P35/00 , C07D417/14
CPC分类号： C07D417/14 , A61K31/444 , A61K45/06
摘要： The invention provides certain thiazole-substituted aminopyridine compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Cy, and the subscript t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
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9.发明公开2-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS 有权2-吡啶基甲酰胺CONTAINING MILZTYROSINKINASE抑制剂
公开(公告)号：EP2763976A4
公开(公告)日：2015-03-04
申请号：EP12838717
申请日：2012-10-01
申请人： MERCK SHARP & DOHME
发明人： ALTMAN MICHAEL D , BIENSTOCK CORE E , BUTCHER JOHN W , DI FRANCESCO MARIA EMILIA , DONOFRIO ANTHONY , ELLIS JOHN MICHAEL , FISCHER CHRISTIAN , HAIDLE ANDREW M , HAIDLE ANDREW M , JEWELL JAMES P , KNOWLES SANDRA LEE , NORTHRUP ALAN B , OTTE RYAN D , PETERSON SCOTT L , SMITH GRAHAM FRANK
IPC分类号： C07D401/00 , A61P37/00
CPC分类号： A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D213/81 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
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公开(公告)号：EP2707357A4
公开(公告)日：2014-12-03
申请号：EP12782164
申请日：2012-05-04
申请人： MERCK SHARP & DOHME
发明人： ALTMAN MICHAEL D , DI FRANCESCO MARIA EMILIA , HAIDLE ANDREW M , OTTE RYAN D , ELLIS JOHN MICHAEL , CHILDERS KALEEN KONRAD , NORTHRUP ALAN B , YANG LIPING
IPC分类号： C07D417/14 , A61K31/444 , A61P37/00
CPC分类号： C07D417/14
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