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公开(公告)号：EP2920172A4
公开(公告)日：2016-05-25
申请号：EP13855780
申请日：2013-11-15
申请人： MERCK SHARP & DOHME
发明人： ACHAB ABDELGHANI ABE , ALTMAN MICHAEL D , DENG YONGQI , KATTAR SOLOMON , KATZ JASON D , METHOT JOEY L , ZHOU HUA , MCGOWAN MEREDETH , CHRISTOPHER MATTHEW P , GARCIA YUDITH , ANTHONY NEVILLE JOHN , FRADERA LLINAS FRANCESC XAVIER , YANG LIPING , MU CHANGWEI , WANG XIAONA , SHI FENG , YE BAIJUN , ZHANG SIXING , ZHAO XIAOLI , ZHANG RONG , FONG KIN CHIU , LENG XIANSHENG
CPC分类号： C07D487/04 , A61K31/52 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D473/34 , C07D519/00 , A61K2300/00
摘要： The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflamation, asthma, COPD and cancer.
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2.发明公开CYCLOALKYLNITRILE PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS 有权CYCLOALKYLNITRILPYRAZOLCARBOXAMIDAS JANUS KINASEINHIBITORS
公开(公告)号：EP2758377A4
公开(公告)日：2015-05-13
申请号：EP12833410
申请日：2012-09-21
申请人： MERCK SHARP & DOHME
发明人： BRUBAKER JASON , DINSMORE CHRISTOPHER J , HOFFMAN DAWN MARIE , JUNG JOON , LIU DUAN , PETERSON SCOTT , SIU TONY , TORRES LUIS E , ZHANG HONGJUN , WEI ZHONGYONG , SHI FENG
IPC分类号： C07D231/10 , A61K31/415 , A61P35/00 , A61P37/00
CPC分类号： C07D405/08 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14
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公开(公告)号：EP2758389A4
公开(公告)日：2015-05-06
申请号：EP12834277
申请日：2012-09-21
申请人： MERCK SHARP & DOHME
发明人： BRUBAKER JASON , CLOSE JOSHUA , SIU TONY , SMITH GRAHAM FRANK , TORRES LUIS E , WOO HYUN CHONG , YOUNG JONATHAN R , WEI ZHONGYONG , SHI FENG
IPC分类号： C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/541 , A61P11/00 , A61P29/00 , A61P35/00 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D405/08 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/14
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公开(公告)号：EP3154976A4
公开(公告)日：2017-11-08
申请号：EP15819372
申请日：2015-06-09
申请人： MERCK SHARP & DOHME
发明人： MCGOWAN MEREDETH ANN , FONG KIN CHIU , ANTHONY NEVILLE JOHN , ZHOU HUA , KATZ JASON D , YANG LIHU , LI CHAOMIN , TIAN YUAN , MU CHANGWEI , YE BAIJUN , SHI FENG , ZHAO XIAOLI , FU JIANMIN , LI YABIN
IPC分类号： C07D473/34 , A61K31/52 , A61P11/00 , A61P19/02 , A61P35/00 , A61P37/00 , C07D473/30 , C07D519/00
CPC分类号： C07D519/00 , A61K31/52 , C07D473/30 , C07D473/34
摘要： Provided are compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.
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公开(公告)号：EP2637503A4
公开(公告)日：2014-04-09
申请号：EP11840448
申请日：2011-11-08
发明人： CHANG JIANG , MCEACHERN ERNEST J , MU CHANGWEI , SHI FENG , VOCADLO DAVID J , WANG YAODE , WEI ZHONGYONG , ZHOU YUANXI , ZHU YONGBAO
IPC分类号： C07H9/06 , A61K31/7056 , C07D513/04
CPC分类号： C07D513/04 , C07H9/06
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