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公开(公告)号：EP3229801A4
公开(公告)日：2018-07-18
申请号：EP15866965
申请日：2015-12-07
发明人： ZHANG TING , CHEN YI-HENG , GUO LIANGQIN , HRUZA ALAN , JIAN TIANYING , LI BING , MENG DONGFANG , PARKER DANN L JR , SHERER EDWARD C , WOOD HAROLD B , SAKURADA ISAO
IPC分类号： A61K31/4184 , C07D235/04
CPC分类号： C07D403/12 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.
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公开(公告)号：EP2605658A4
公开(公告)日：2014-05-07
申请号：EP11818600
申请日：2011-08-12
申请人： MERCK SHARP & DOHME
发明人： DUFFY JOSEPH L , BAO JIANMING , ONDEYKA DEBRA L , TYAGARAJAN SRIRAM , SHAO PATRICK , YE FENG , KATIPALLY REVATHI , SHERER EDWARD C , PLOTKIN MICHAEL A , MONINGKA REMOND , HUSSIAN ZAHID , WOOD HAROLD B , UJJAINWALLA FEROZE , ROMERO ANTHONY , FINKE PAUL , ZANG YI , LIU WEIGUO , ZWICKER AARON
IPC分类号： C07D498/10 , A61K31/42 , A61P3/00 , A61P9/00 , A61P25/00 , C07D519/00
CPC分类号： C07D498/10 , C07D519/00
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公开(公告)号：EP3027593A4
公开(公告)日：2017-03-29
申请号：EP14832049
申请日：2014-07-29
发明人： WILLIAMS PETER D , MCCAULEY JOHN A , BENNETT DAVID J , BUNGARD CHRISTOPHER J , CHANG LEHUA , CHU XIN-JIE , DWYER MICHAEL P , HOLLOWAY M KATHERINE , KEERTIKAR KARTIK M , LOUGHRAN H MARIE , MANIKOWSKI JESSE J , MORRIELLO GREGORI J , SHEN DONG-MING , SHERER EDWARD C , SCHULZ JURGEN , WADDELL SHERMAN TIM , WISCOUNT CATHERINE M , ZORN NICOLAS , SATYANARAYANA TUMMANAPALLI , VIJAYASARADHI SIVALENKA , HU BIN , JI TAO , ZHONG BIN
IPC分类号： C07D401/14 , A61K31/496 , A61P31/18 , C07D241/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D241/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
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