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1.发明公开SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS 有权取代的嘧啶衍生物及其吡啶和治疗病毒感染
公开(公告)号：EP2536410A4
公开(公告)日：2013-10-09
申请号：EP11745338
申请日：2011-02-18
发明人： ARASAPPAN ASHOK , NJOROGE GEORGE F , KWONG CECIL D , ANANTHAN SUBRAMANIAM , BENNETT FRANK , GENG FENG , GIRIJAVALLABHAN VINAY M , HUANG YUHUA , KEZAR HOLLIS S III , MADDRY JOSEPH A , REYNOLDS ROBERT C , ROYCHOWDHURY ABHIJIT , FOWLER ANITA T , SECRIST JOHN A III , KOZLOWSKI JOSEPH A , SHANKAR BANDARPALLE B , TONG LING , KIM SEONG HEON , MACCOSS MALCOLM
IPC分类号： A61K31/506 , A61P31/14
CPC分类号： A61K31/506 , A61K45/06 , C07D403/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D491/048 , C07D513/04
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公开(公告)号：EP2430034A4
公开(公告)日：2013-05-15
申请号：EP10775445
申请日：2010-05-12
申请人： SOUTHERN RES INST
IPC分类号： C07H19/16 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61P35/00 , C07H19/06
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3.发明公开METHODS FOR SYNTHESIZING 2-CHLORO-9-(2-DEOXY-2-FLUORO-$g(b)-D-ARABINOFURANOSYL)- i 9H /i -PURIN-6-AMINE 有权PROCESS FOR 2-氯-9-（2-脱氧-2-氟-β-D-阿拉伯呋喃糖基）的制备-9H-嘌呤-6-胺
公开(公告)号：EP1261350A4
公开(公告)日：2003-04-16
申请号：EP01910961
申请日：2001-02-16
申请人： SOUTHERN RES INST
CPC分类号： C07H19/16
摘要： 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-9-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofuranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine. When the purine reactant is substituted in the 6 position with a halogen, a reaction step with an alkoxide is carried out prior to the reaction with ammonia.
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