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1.发明公开SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS 有权取代的嘧啶衍生物及其吡啶和治疗病毒感染
公开(公告)号：EP2536410A4
公开(公告)日：2013-10-09
申请号：EP11745338
申请日：2011-02-18
发明人： ARASAPPAN ASHOK , NJOROGE GEORGE F , KWONG CECIL D , ANANTHAN SUBRAMANIAM , BENNETT FRANK , GENG FENG , GIRIJAVALLABHAN VINAY M , HUANG YUHUA , KEZAR HOLLIS S III , MADDRY JOSEPH A , REYNOLDS ROBERT C , ROYCHOWDHURY ABHIJIT , FOWLER ANITA T , SECRIST JOHN A III , KOZLOWSKI JOSEPH A , SHANKAR BANDARPALLE B , TONG LING , KIM SEONG HEON , MACCOSS MALCOLM
IPC分类号： A61K31/506 , A61P31/14
CPC分类号： A61K31/506 , A61K45/06 , C07D403/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D491/048 , C07D513/04
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2.发明公开
公开(公告)号：EP2488028A4
公开(公告)日：2013-05-01
申请号：EP10823840
申请日：2010-10-05
申请人： MERCK SHARP & DOHME
发明人： BOGEN STEPHANE L , MA YAO , WANG YAOLIN , LAHUE BRIAN ROBERT , NAIR LATHA G , SHIZUKA MANAMI , VOSS MATTHEW ERNST , KIROVA-SNOVER MARGARITA , PAN WEIDONG , TIAN YUAN , KULKARNI BHEEMASHANKAR A , GIBEAU CRAIG R , LIU YUAN , SCAPIN GIOVANNA , RINDGEN DIANE , DOLL RONALD J , GUZI TIMOTHY J , HICKLIN DANNY J , NOMEIR AMIN , SEIDEL-DUGAN CYNTHIA , SHIPPS GERALD W JR , MACCOSS MALCOLM
IPC分类号： C07D401/14 , C07D409/14
CPC分类号： C07D401/14 , C07D409/14
摘要： The present invention provides a compound of Formula 1 as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
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3.发明公开RIBONUCLEOSIDE CYCLIC ACETAL DERIVATIVES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION 审中-公开核糖核苷的环状缩醛FOR RNA-依赖性RNA病毒感染的治疗
公开(公告)号：EP1915054A4
公开(公告)日：2010-09-01
申请号：EP06789454
申请日：2006-08-04
申请人： MERCK SHARP & DOHME
发明人： BUTORA GABOR , KOEPLINGER KENNETH ALAN , MACCOSS MALCOLM , MCMASTERS DANIEL R , OLSEN DAVID B , YANG LIHU
IPC分类号： A01N43/04 , A01N57/00 , A61K31/519
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公开(公告)号：EP1720556A4
公开(公告)日：2012-05-09
申请号：EP05750052
申请日：2005-02-14
发明人： REDDY RAJA K , ERION MARK D , MACCOSS MALCOLM , OLSEN DAVID B
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