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1.发明公开2,3-SUBSTITUTED FUSED BICYCLIC PYRIMIDIN-4(3H)-ONES MODULATING THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) 审中-公开香草素-1受体（VR1）调制的功能取代的2,3-稠合双环嘧啶-4（3H） - 酮
公开(公告)号：EP1881988A1
公开(公告)日：2008-01-30
申请号：EP06759506.6
申请日：2006-05-10
发明人： BROWN, Rebecca Elizabeth , HUMPHRIES, Alexander Charles , ROGERS, Lauren , BAYLISS, Tracy , JONES, A., Brian , MOYES, Christopher Richard , HOLLINGWORTH, Gregory John , BLUM, Charles, A. , ZHENG, Xiaozhang , BAKTHALVATCHALAM, Rajagopal , CAPITOSTI, Scott
IPC分类号： C07D495/04 , C07D513/04 , C07D473/00 , A61K31/495 , A61P11/00 , A61P29/00
CPC分类号： C07D495/04 , C07D473/00 , C07D513/04
摘要： The use of a compound of formula (I): for the manufacture of a medicament for the treatment of conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1, also known as TRPV1).
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2.发明公开HETEROAROMATIC UREA DERIVATIVES AS VR-1 RECEPTOR MODULATORS FOR TREATING PAIN 审中-公开杂芳脲衍生物AS VR-1受体拮抗剂疼痛的治疗
公开(公告)号：EP1490340A1
公开(公告)日：2004-12-29
申请号：EP03710014.6
申请日：2003-03-21
发明人： BROWN, Rebecca, Elizabeth , DOUGHTY, Victoria, Alexandra , HOLLINGWORTH, Gregory, John , JONES, A., Brian , LINDON, Matthew, John , MOYES, Christopher, Richard , ROGERS, Lauren
IPC分类号： C07D215/38 , C07D215/40 , C07D217/22 , C07D217/24 , C07D217/26 , C07D237/28 , C07D401/12 , C07D401/14 , C07D521/00 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61K31/501 , A61K31/506 , A61P29/00
CPC分类号： C07D401/12 , C07D215/38 , C07D217/02 , C07D217/08 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds of formula (I); pharmaceutically acceptable salts and N-oxides thereof in which A, B, D and E are C or N with the proviso that one or more are N, R1, R2, R3, R4, R5 and R6 are simple substituents, n is 0-3 and y is an aryl, heteroaryl, carbocyclyl or fused-carbocyclyl group; as VR-1 antagonists for treating conditions or diseases in which pain and/or inflammation predominates; the use of the same for manufacturing medicaments, pharmaceutical compositions comprising them and methods of treatment utilising them.
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3.发明公开BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) 审中-公开双环嘧啶-4-（3H） - 酮和其类似物和衍生物，香草素-1受体的功能（VR1）MODULATE
公开(公告)号：EP1687306A1
公开(公告)日：2006-08-09
申请号：EP04798536.1
申请日：2004-11-12
发明人： BAYLISS, Tracy , HOLLINGWORTH, Gregory, John , JARVIS, Rebecca, Elizabeth , JONES, A., Brian , SPAREY, Timothy, Jason
IPC分类号： C07D471/04 , C07D495/04 , C07D513/04 , C07D473/22 , C07D473/18 , A61K31/522 , A61P25/04
CPC分类号： C07D473/22 , C07D471/04 , C07D473/18 , C07D473/24 , C07D495/04 , C07D513/04
摘要： Compounds of formula (I); which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).
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