公开(公告)号：EP1594537B1

公开(公告)日：2012-10-24

申请号：EP03815962.0

申请日：2003-02-19

申请人： MERIAL

发明人： AUDONNET, Jean-Christophe, Francis ,  FISCHER, Laurent, Bernard ,  BARZU-LE-ROUX, Simona

IPC分类号： A61K39/12 ,  A61K39/245 ,  A61K39/155 ,  C12N15/09 ,  C12N15/33 ,  C12N15/38 ,  C12N15/40 ,  C12N15/45 ,  A61P11/00

CPC分类号： A61K39/12 ,  A61K39/155 ,  A61K39/245 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55572 ,  C12N2710/16734 ,  C12N2710/24043 ,  C12N2760/18534 ,  C12N2770/24334

公开(公告)号：EP2283035A2

公开(公告)日：2011-02-16

申请号：EP09743563.0

申请日：2009-05-06

申请人： Merial Ltd. ,  GOV'T of The U.S.A. as represented by the secretary of the departement of health and human services

发明人： FISCHER, Laurent, Bernard ,  VALENZUELA, Jesus, G.

IPC分类号： C07K14/435 ,  A61K39/008 ,  A61K39/00 ,  G01N33/68 ,  C12N15/12 ,  C07K16/18

CPC分类号： C07K14/43577 ,  A61K39/00 ,  A61K39/0003 ,  A61K45/06 ,  A61K2039/53 ,  A61K2039/58 ,  Y02A50/41

摘要： The present invention provides vectors that contain and express in vivo or in vitro sand fly Lu. longipalpis salivary antigens that elicit an immune response in animal or human against Leishmania, vaccine compositions comprising said vectors and/or Lu. longipalpis salivary polypeptides, methods of vaccination against Leishmania, and kits for use with such methods and compositions.

公开(公告)号：EP2283035B1

公开(公告)日：2015-07-29

申请号：EP09743563.0

申请日：2009-05-06

申请人： Merial Limited ,  The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services

发明人： FISCHER, Laurent, Bernard ,  VALENZUELA, Jesus, G. ,  RIBEIRO, Jose ,  KAMHAWI, Shaden

IPC分类号： C07K14/435 ,  A61K39/008 ,  A61K39/00 ,  G01N33/68 ,  C12N15/12 ,  C07K16/18

CPC分类号： C07K14/43577 ,  A61K39/00 ,  A61K39/0003 ,  A61K45/06 ,  A61K2039/53 ,  A61K2039/58 ,  Y02A50/41

摘要： The present invention provides vectors that contain and express in vivo or in vitro sand fly Lu. longipalpis salivary antigens that elicit an immune response in animal or human against Leishmania, vaccine compositions comprising said vectors and/or Lu. longipalpis salivary polypeptides, methods of vaccination against Leishmania, and kits for use with such methods and compositions.

公开(公告)号：EP1248650B1

公开(公告)日：2006-11-29

申请号：EP01907651.2

申请日：2001-01-19

申请人： MERIAL

发明人： AUDONNET, Jean-Christophe, Francis ,  FISCHER, Laurent, Bernard ,  BARZU-LE-ROUX, Simona

IPC分类号： A61K39/39 ,  A61K47/18 ,  A61P31/12 ,  C12N15/38

CPC分类号： A61K47/24 ,  A61K9/0019 ,  A61K39/39 ,  A61K47/186 ,  A61K2039/53 ,  A61K2039/55511

摘要： The invention concerns a DNA vaccine against a pathogen affecting production-type animals, in particular cattle and swine, comprising a plasmid containing a nucleotide sequence coding for an immunogen of a pathogen of the animal species concerned, in conditions enabling the expression in vivo of said sequence, and a cationic lipid containing a quaternary ammonium salt, of formula (I) wherein: R1 is a linear aliphatic radical, saturated or unsaturated, having 12 to 18 carbon atoms; R2 is another aliphatic radical, containing 2 or 3 carbon atoms; and X is a hydroxyl or amine group, said lipid being preferably DMRIE.

公开(公告)号：EP2205743A1

公开(公告)日：2010-07-14

申请号：EP08836475.7

申请日：2008-10-07

申请人： Merial Limited

发明人： FISCHER, Laurent, Bernard

IPC分类号： C12N15/12 ,  C12N15/861 ,  A61K48/00 ,  C07K14/51 ,  A61K38/18

CPC分类号： A61K48/0075 ,  A01K2207/10 ,  A01K2227/102 ,  C07K14/51 ,  C12N15/86 ,  C12N2710/10343

摘要： The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of osteoarthritis in mammals, advantageously in humans, dogs, horses and cats, by intraarticular administration of the recombinant vectors and pharmaceutical compositions of the invention.

摘要翻译： 本发明涉及在宿主细胞中表达BMP-7多肽的重组载体以及包含这种重组载体的药物组合物。 本发明还包括通过关节内施用本发明的重组载体和药物组合物来预防和/或治疗哺乳动物，有利地在人，狗，马和猫中的骨关节炎的方法。

公开(公告)号：EP1248650A2

公开(公告)日：2002-10-16

申请号：EP01907651.2

申请日：2001-01-19

申请人： MERIAL

发明人： AUDONNET, Jean-Christophe, Francis ,  FISCHER, Laurent, Bernard ,  BARZU-LE-ROUX, Simona

IPC分类号： A61K39/39 ,  A61K47/18 ,  A61P31/12 ,  C12N15/31

CPC分类号： A61K47/24 ,  A61K9/0019 ,  A61K39/39 ,  A61K47/186 ,  A61K2039/53 ,  A61K2039/55511

摘要： The invention concerns a DNA vaccine against a pathogen affecting production-type animals, in particular cattle and swine, comprising a plasmid containing a nucleotide sequence coding for an immunogen of a pathogen of the animal species concerned, in conditions enabling the expression in vivo of said sequence, and a cationic lipid containing a quaternary ammonium salt, of formula (I) wherein: R1 is a linear aliphatic radical, saturated or unsaturated, having 12 to 18 carbon atoms; R2 is another aliphatic radical, containing 2 or 3 carbon atoms; and X is a hydroxyl or amine group, said lipid being preferably DMRIE.

公开(公告)号：EP2890392B1

公开(公告)日：2019-04-17

申请号：EP13760212.4

申请日：2013-08-30

申请人： Merial, Inc.

发明人： FISCHER, Laurent, Bernard ,  CARBOULEC, Nicolas Pierre, Yves ,  LUX, Fabien

IPC分类号： A61K39/008 ,  C07K1/113 ,  C12N15/62

公开(公告)号：EP2205743B1

公开(公告)日：2017-07-19

申请号：EP08836475.7

申请日：2008-10-07

申请人： Merial, Inc

发明人： FISCHER, Laurent, Bernard

IPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/51

CPC分类号： A61K48/0075 ,  A01K2207/10 ,  A01K2227/102 ,  C07K14/51 ,  C12N15/86 ,  C12N2710/10343

公开(公告)号：EP2629791B1

公开(公告)日：2016-12-07

申请号：EP11770986.5

申请日：2011-10-13

申请人： Merial, Inc.

发明人： FISCHER, Laurent, Bernard

IPC分类号： A61K48/00 ,  A61K39/00

CPC分类号： A61K39/0011 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/545

摘要： The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as an adjunct treatment for surgery, radiation and/or chemotherapy for dogs and cats with cancers that over express the Her2 antigen, and prolong the post-surgical disease free interval and/or survival time. Also included are therapeutically effective methods of immunization using said vaccines.

公开(公告)号：EP2890392A1

公开(公告)日：2015-07-08

申请号：EP13760212.4

申请日：2013-08-30

申请人： Merial, Inc.

发明人： FISCHER, Laurent, Bernard ,  CARBOULEC, Nicolas Pierre, Yves ,  LUX, Fabien

IPC分类号： A61K39/008 ,  C07K1/113 ,  C12N15/62

CPC分类号： C07K14/245 ,  A23L3/0155 ,  A61K39/008 ,  A61K39/0225 ,  A61K39/0241 ,  A61K39/099 ,  A61K2039/552 ,  A61L2/0011 ,  C07K14/44 ,  C07K2319/00 ,  C07K2319/35 ,  C07K2319/40 ,  C12N5/0031 ,  C12N9/1007 ,  C12N9/50 ,  C12N9/52 ,  C12P21/02 ,  C12Y201/01041 ,  C12Y304/22

摘要： The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.

摘要翻译： 本发明涉及一种高压设备用于灭活微生物和病毒，同时保留它们的免疫原性和用于从来自原核生物或真核生物生产包涵体制备和生产可溶性，分解，重折叠或活性的免疫原性或治疗性蛋白。 本发明包括一种使用灭活的病原体的疫苗组合物用于灭活病原生物体高压方法和方法。 该hyperbarically灭活微生物更安全，比化学灭活微生物的免疫原性更强。 类似地，溶解的蛋白质具有优异的性能相比更重聚集蛋白，包括降低的非特异性免疫反应。