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公开(公告)号：EP0347852B1
公开(公告)日：1995-08-23
申请号：EP89111230.2
申请日：1989-06-20
IPC分类号： C07D473/00 , C07D471/04 , A61K31/52
CPC分类号： C07D473/00 , C07D471/04
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2.发明公开Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase 失效作为平均环氧化物酶抑制剂的平均二异氰酸酯和四氟乙酰胺类似物
公开(公告)号：EP0448934A3
公开(公告)日：1991-11-27
申请号：EP91101057.7
申请日：1991-01-28
CPC分类号： C07C21/215
摘要： This invention relates to certain novel di- and tetra-fluoro analogs of squalene and to their methods of use in lowering plasma cholesterol and in inhibiting squalene epoxidase in patients in need thereof.
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公开(公告)号：EP0244803A3
公开(公告)日：1991-01-16
申请号：EP87106440.8
申请日：1987-05-04
IPC分类号： C07D409/04 , C07D405/04 , C07D401/04 , C07D403/04 , C07D417/04 , C07D409/06 , C07D405/06 , C07D401/06 , C07D403/06 , C07D417/06 , C07D233/84
CPC分类号： C07D401/04 , C07D233/84 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/06
摘要： This invention relates to novel imidazole derivatives which are inhibitors of dopamine beta-hydroxylase useful as antihypertensive agents.
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4.发明公开Novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl adenosine derivatives 失效新的2'-羟基乙烯基，2'-乙烯基和2'-乙烯基腺苷衍生物
公开(公告)号：EP0365849A3
公开(公告)日：1990-12-27
申请号：EP89117735.4
申请日：1989-09-26
发明人： McCarthy, James R. , Stemerick, David M. , Prakash, Nellikunja J. , Edwards, Michael L. , Jarvi, Esa T.
CPC分类号： C07H19/16 , C07H19/052 , C07H19/056
摘要： This invention relates to certain novel 2′-halomethylidene, 2′-ethenylidene and 2′-ethynyl adenosine derivatives, and pharmaceutical compositions thereof, which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.
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公开(公告)号：EP0374440A2
公开(公告)日：1990-06-27
申请号：EP89120206.1
申请日：1989-10-31
IPC分类号： A61K31/13 , A61K31/135 , A61K31/445 , A61K31/40 , A61K31/38 , A61K31/34
CPC分类号： A61K31/40 , A61K31/13 , A61K31/135 , A61K31/34 , A61K31/38 , A61K31/445
摘要： This invention relates to pharmaceutical compositions containing certain inhibitors of lysyl oxidase for the treatment of diseases and conditions associated with the abnormal deposition of collagen.
摘要翻译： 本发明涉及含有某些赖氨酰氧化酶抑制剂用于治疗与胶原异常沉积有关的疾病和病症的药物组合物。
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6.发明公开Novel (aryl or heteroaromatic methyl)-2,2'-BI-1H-imidazoles 失效（Aryl oder heteraromatische methyl）-2,2'-Bi-1H-咪唑。
公开(公告)号：EP0301456A2
公开(公告)日：1989-02-01
申请号：EP88111954.9
申请日：1988-07-25
IPC分类号： C07D409/14 , A61K31/415 , C07D405/14 , C07D417/14 , A61K31/34 , A61K31/38 , A61K31/425 , C07D233/60 , C07D233/56
CPC分类号： C07D233/56 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This invention relates to novel (aryl or heteroaromatic methyl)-2,2′-1H-biimidazoles; to a process for their production comprising of reacting an appropriate alpha-brominated or alpha-chlorinated, substituted or non-substituted, methylated monoaromatic ring compound with 2,2′-bi-1H-imidazole in a solvent such as ethanol in the presence of a base such as sodium hydroxide under reflux conditions; and to pharmaceutical compositions and methods of treating hypertension with such compounds.
摘要翻译： 本发明涉及新的（芳基或杂芳族甲基）-2,2min-1H-联咪唑; 涉及一种制备方法，包括使适当的α-溴代或α-氯代，取代或未取代的甲基化单芳族环化合物与2,2'-联-1H-咪唑在溶剂如乙醇中，在 碱如氢氧化钠在回流条件下反应; 以及用这些化合物治疗高血压的药物组合物和方法。
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7.发明授权Substituted 1,2,3-triazino(4',5':4,5)-thieno(2,3-b)quinoline-4(3H)-ones 失效取代的1,2,3-三嗪基（4'，5'：4,5） - 噻吩并（2,3-b）喹啉-4（3H） - 酮
公开(公告)号：EP0126487B1
公开(公告)日：1988-08-24
申请号：EP84105833.2
申请日：1984-05-22
IPC分类号： C07D495/14 , C07D495/22 , A61K31/53
CPC分类号： C07D495/04 , C07D215/20 , C07D215/54 , C07D495/14
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公开(公告)号：EP0229922A2
公开(公告)日：1987-07-29
申请号：EP86116131.3
申请日：1986-11-21
IPC分类号： C07D233/90 , C07D401/04 , C07F7/08 , A61K31/215 , A61K31/44
CPC分类号： C07D233/64 , C07D231/12 , C07D233/06 , C07D233/56 , C07D233/68 , C07D233/90 , C07D249/08 , C07F7/0812
摘要： This invention relates to novel derivatives of 2,2'-bi-1H-imidazoles, to the processes and intermediates used in their preparation, to their ability to exert the pharmacologic effects of lowering high blood pressure and of increasing heart contractile force and to their use as chemotherapeutic agents useful in treating cardiac insufficiency and hypertension.
摘要翻译： 本发明涉及2,2min -bi-1H-咪唑的新型衍生物，其制备中使用的方法和中间体，其发挥降低高血压和增加心脏收缩力的药理作用的能力及其 用作治疗心功能不全和高血压的化学治疗剂。
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9.发明授权Novel (aryl or heteroaromatic methyl)-2,2'-BI-1H-imidazoles 失效（Aryl oder heteraromatische methyl）-2,2'-Bi-1H-咪唑。
公开(公告)号：EP0301456B1
公开(公告)日：1994-02-02
申请号：EP88111954.9
申请日：1988-07-25
IPC分类号： C07D409/14 , A61K31/415 , C07D405/14 , C07D417/14 , A61K31/34 , A61K31/38 , A61K31/425 , C07D233/60 , C07D233/56
CPC分类号： C07D233/56 , C07D405/14 , C07D409/14 , C07D417/14
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公开(公告)号：EP0229922B1
公开(公告)日：1992-04-15
申请号：EP86116131.3
申请日：1986-11-21
IPC分类号： C07D233/90 , C07D401/04 , C07F7/08 , A61K31/215 , A61K31/44
CPC分类号： C07D233/64 , C07D231/12 , C07D233/06 , C07D233/56 , C07D233/68 , C07D233/90 , C07D249/08 , C07F7/0812
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