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1.发明公开Method for reducing reperfusion injury with imidazol-2-thione-carboxamides 失效减少IMIDAZOL-2-THIONE-CARBOXAMIDES的再灌注损伤的方法
公开(公告)号：EP0312960A3
公开(公告)日：1990-06-13
申请号：EP88117251.4
申请日：1988-10-17
IPC分类号： A61K31/415 , A61K31/44
CPC分类号： A61K31/415 , A61K31/44
摘要： Certain 2-oxo- and 2-thioxoimidazol-4-carboxamides are reported to reduce reperfusion injury which is the injury which occurs when molecular oxygen is reintroduced into an ischemic tissue. These compounds could be used to prevent much of the damage which occurs to the heart of a heart attack victim.
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公开(公告)号：EP0170214B1
公开(公告)日：1989-09-13
申请号：EP85109363.3
申请日：1985-07-25
IPC分类号： C07D213/46 , C07D401/06
CPC分类号： C07D401/06 , C07D213/48 , C07D213/50
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公开(公告)号：EP0293777A1
公开(公告)日：1988-12-07
申请号：EP88108496.6
申请日：1988-05-27
IPC分类号： C07D498/04 , A61K31/435
CPC分类号： C07D498/04
摘要： The present invention relates to tricyclic oxazolones of the formula
wherein Q is a divalent sulfur or oxygen atom;
one of X and Z is an oxygen atom and the other is an imino group; and
n is 0 or the integer 1 or 2,
which enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.摘要翻译： 本发明涉及式CHEM的三环恶唑酮，其中Q是二价硫或氧原子; X和Z之一是氧原子，另一个是亚氨基; 并且n为0或整数1或2，其增强心肌收缩力，并且可用作治疗心力衰竭的强心剂。
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4.发明授权4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones 失效4-（4-苯基-1-哌啶基）甲基-5-酰基-1,3-二氢-2H-咪唑-2-酮
公开(公告)号：EP0064707B1
公开(公告)日：1986-07-23
申请号：EP82103743.9
申请日：1982-05-03
IPC分类号： C07D401/06 , C07D405/06 , C07D409/06 , A61K31/44 , A61K31/415
CPC分类号： C07D233/70 , Y10S514/822
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5.发明授权5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives 失效5-氨基乙基-2,3-二氢-2-氧代-1H-咪唑-4-羧酸衍生物
公开(公告)号：EP0064705B1
公开(公告)日：1986-06-18
申请号：EP82103740.5
申请日：1982-05-03
IPC分类号： C07D233/90 , C07D401/06 , A61K31/415 , A61K31/44
CPC分类号： C07D233/90
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6.发明授权5-(4-Phenyl-1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives 失效5-（4-苯基-1-哌啶子基）甲基-2,3-二氢-2-氧代-1H-咪唑-4-羧酸衍生物
公开(公告)号：EP0064706B1
公开(公告)日：1985-07-03
申请号：EP82103742.1
申请日：1982-05-03
IPC分类号： C07D401/06 , A61K31/44 , A61K31/415
CPC分类号： C07D233/90 , Y10S514/822
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公开(公告)号：EP0079049A2
公开(公告)日：1983-05-18
申请号：EP82110157.3
申请日：1982-11-04
IPC分类号： C07D233/70 , C07D233/84 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , A61K31/415 , A61K31/44 , A61K31/34 , A61K31/38
CPC分类号： C07D233/84 , C07D233/70
摘要： Novel 4-alkanoylimidazol-2-ones of the following general structure which are useful as cardiotonics in the treatment of cardiac failure
wherein Q and T are each an oxygen atom or a divalent sulfur atom; R is hydrogen, lower alkyl, lower alkylcarbonyl or benzoyl; R, is hydrogen or lower alkyl; R 2 is a lower aliphatic hydrocarbon radical, phenyl alkylene or heterocyclo alkylene; and the pharmaceutically acceptable salts thereof.摘要翻译： 用于治疗心力衰竭的强心剂的以下一般结构的新型4-链烷酰基咪唑-2-酮其中Q和T各自为氧原子或二价硫原子; R是氢，低级烷基，低级烷基羰基或苯甲酰基; R1是氢或低级烷基; R2是低级脂族烃基，苯基亚烷基或杂环亚烷基; 及其药物上可接受的盐。
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8.发明公开
公开(公告)号：EP0140375A3
公开(公告)日：1988-06-22
申请号：EP84113085
申请日：1984-10-30
IPC分类号： C07D213/64 , A61K31/44
CPC分类号： C07D213/42 , C07D213/64 , C07D213/73 , C07D213/80 , C07D213/82 , C07D213/85
摘要： This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
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公开(公告)号：EP0219112A3
公开(公告)日：1988-03-23
申请号：EP86114263
申请日：1986-10-15
IPC分类号： C07D277/34 , C07D417/06 , C07D417/10 , A61K31/425 , A61K31/335 , A61K31/415
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/34 , C07D417/06
摘要： Aroylthiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
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公开(公告)号：EP0222358A1
公开(公告)日：1987-05-20
申请号：EP86115560.4
申请日：1986-11-10
IPC分类号： C07D413/04 , A61K31/42
CPC分类号： C07D413/04
摘要： Heterocyclic oxazolones enhance myocardial contractile force and cardiac function and are used as cardiotonics in the treatment of heart failure.
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