公开(公告)号：EP1176140A4

公开(公告)日：2002-07-31

申请号：EP00902925

申请日：2000-02-10

申请人： MITSUBISHI PHARMA CORP

发明人： USHIO HIROYUKI ,  ISHIBUCHI SEIGO ,  NAITO YOUICHIRO ,  SUGIYAMA NAOKI ,  KAWAGUCHI TAKAFUMI ,  CHIBA KENJI ,  OHTSUKI MAKIO ,  NAKA YOICHI

IPC分类号： A61K31/00 ,  A61K31/135 ,  A61K31/40 ,  A61K45/06 ,  A61P29/00 ,  A61P37/06 ,  A61P43/00 ,  C07D207/34 ,  C07D231/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D491/10 ,  C07D491/113 ,  A61K31/415 ,  A61P37/00 ,  C07D231/16 ,  C07D231/22 ,  C07D521/00

CPC分类号： C07D401/12 ,  A61K31/00 ,  A61K31/135 ,  A61K31/40 ,  A61K45/06 ,  C07D207/34 ,  C07D231/14 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D491/10 ,  A61K2300/00

摘要： Compounds represented by general formula (I) or salts thereof and drugs comprising these compounds wherein R1 represents substituted aryl, heteroaryl, etc.; R?2 and R3¿ represent each hydrogen, alkyl, halogeno, hydroxy, etc.; Q represents N, CH, etc.; W represents hydrogen, alkyl, hydroxycarbonylalkyl, etc.; X represents halogeno, cyano, nitro, amino, etc.; X' represents hydrogen, halogeno, cyano or nitro; and Y represents alkyl, hydroxy, alkoxy, mercapt, etc. Because of having an excellent effect of inhibiting the proliferation of activated lymphocytes, these drugs are useful as preventives or remedies for various autoimmune diseases.

摘要翻译： 由通式（I）表示的化合物或其盐和包含这些化合物的药物，其中R 1表示取代的芳基，杂芳基等; R 2和R 3各自代表氢，烷基，卤代，羟基等; Q代表N，CH等; W代表氢，烷基，羟基羰基烷基等; X代表卤代，氰基，硝基，氨基等; X'代表氢，卤代，氰基或硝基; Y代表烷基，羟基，烷氧基，巯基等。由于具有优异的抑制活化淋巴细胞增殖作用，所以这些药物可用作各种自身免疫疾病的预防剂或治疗剂。

公开(公告)号：EP1310488A4

公开(公告)日：2005-08-10

申请号：EP01955619

申请日：2001-08-09

申请人： MITSUBISHI PHARMA CORP

发明人： USHIO HIROYUKI ,  NAITO YOUICHIRO ,  SUGIYAMA NAOKI ,  KAWAGUCHI TAKAFUMI ,  OHTSUKI MAKIO ,  CHIBA KENJI

IPC分类号： A61K31/015 ,  A61K31/343 ,  A61K31/381 ,  A61K31/404 ,  A61K31/4184 ,  A61K31/4365 ,  A61K31/4704 ,  A61K31/498 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00 ,  C07D209/42 ,  C07D211/46 ,  C07D307/85 ,  C07D307/86 ,  C07D333/70 ,  C07D405/12 ,  C07D409/12 ,  C07D495/04 ,  C07D209/64 ,  A61K31/352 ,  A61K31/37 ,  A61K31/455 ,  A61P35/00 ,  C07C253/00

CPC分类号： C07D405/12 ,  A61K31/015 ,  A61K31/343 ,  A61K31/381 ,  A61K31/404 ,  A61K31/4184 ,  A61K31/4365 ,  A61K31/4704 ,  A61K31/498 ,  C07D209/42 ,  C07D211/46 ,  C07D307/85 ,  C07D307/86 ,  C07D333/70 ,  C07D409/12 ,  C07D495/04

摘要： Compounds represented by the following general formula (I) wherein the ring A represents benzene, cyclohexane, pyridine, piperidine, a derivative thereof, imidazole, a derivative thereof, etc.; the ring B represents benzene, cyclohexane, pyrrole, a derivative thereof, furan, thiophene, etc.; R?1, R2 and R3¿ represent each hydrogen, alkyl, halogeno, hydroxy, alkoxy, etc.; W represents hydrogen, alkyl or hydroxycarbonylalkyl; X represents halogeno, cyano, nitro, etc.; X' represents hydrogen, halogeno, etc.; and Y represents alkyl, hydroxyalkyl, hydroxycarbonylalkyl, aminoalkyl, etc.; salts thereof and drugs comprising these compounds. Because of having an excellent effect of inhibiting activated lymphocyte proliferation, these compounds are useful as preventives or remedies for various autoimmune diseases.