公开(公告)号：EP1768951A2

公开(公告)日：2007-04-04

申请号：EP05790012.8

申请日：2005-06-17

申请人： MUSC Foundation For Research Development ,  Dix, Thomas A.

发明人： DIX, Thomas, A.

IPC分类号： C07C229/00 ,  C07C205/00 ,  C07C57/30 ,  C07D231/06

CPC分类号： C07C279/14 ,  A61K38/00 ,  C07C229/08 ,  C07C229/12 ,  C07C257/14 ,  C07D231/06 ,  C07D233/46 ,  C07D233/48 ,  C07D239/14 ,  C07K7/083

摘要： This invention relates to non-natural desamino alkyl amino acid compounds, methods of making, and peptides containing these compounds as their N-terminus moieties. A preferred example is neurotensin (8-13) in which the N terminus is an alpha desamino, alpha methyl N,N dimethyl homolysine residue.

公开(公告)号：EP1366017A2

公开(公告)日：2003-12-03

申请号：EP01971028.4

申请日：2001-09-12

申请人： MUSC Foundation For Research Development

发明人： DIX, Thomas, A.

IPC分类号： C07C229/26 ,  C07C257/14 ,  C07C279/14 ,  C07D239/14 ,  C07K2/00 ,  A61K38/00

CPC分类号： C07D233/48 ,  A61K38/00 ,  C07C229/26 ,  C07C257/14 ,  C07C279/14 ,  C07D239/14 ,  C07K1/006 ,  C07K1/063 ,  C07K1/064 ,  C07K5/0812

摘要： This invention relates to positively charged non-natural amino acids, methods of making thereof, and utilization thereof in peptides.

公开(公告)号：EP1962884A2

公开(公告)日：2008-09-03

申请号：EP06848547.3

申请日：2006-12-15

申请人： Argolyn Bioscience, Inc. ,  MEDICAL UNIVERSITY OF SOUTH CAROLINA ,  Brower, Justin O. ,  Dix, Thomas A.

发明人： BROWER, Justin, O. ,  DIX, Thomas, A.

IPC分类号： A61K38/16 ,  C07C229/02

CPC分类号： C07C279/14 ,  A61K38/00 ,  C07C229/26 ,  C07D233/48 ,  C07D239/14

摘要： This invention relates to non-natural desamino amino acid compounds, methods of making, and peptides containing these compounds as their N-terminus moieties. A preferred example is neurotensin (8-13) in which the N terminus is an alpha desamino N,N dimethyl homolysine residue.