公开(公告)号：EP1833482A2

公开(公告)日：2007-09-19

申请号：EP06717281.7

申请日：2006-01-03

申请人： MYRIAD GENETICS, INC. ,  Cytovia, Inc.

发明人： CAI, Sui Xiong ,  ANDERSON, Mark B. ,  WILLARDSEN, Adam ,  SIRISOMA, Nilantha Sudath ,  ZHANG, Hong ,  SUZUKI, Kazuyuki

IPC分类号： A61K31/50 ,  A61K31/519 ,  A61K31/517 ,  C07D239/72 ,  C07D239/00 ,  C07D241/04 ,  C07D265/12 ,  C07D321/00 ,  C07D401/00 ,  C07D403/00 ,  C07D498/00

CPC分类号： C07D239/94 ,  C07D239/72 ,  C07D403/12

摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

公开(公告)号：EP1833803A2

公开(公告)日：2007-09-19

申请号：EP06733603.2

申请日：2006-01-03

申请人： MYRIAD GENETICS, INC. ,  Cytovia, Inc.

发明人： CAI, Sui Xiong ,  ANDERSON, Mark B. ,  WILLARDSEN, Adam ,  JIANG, Songchun ,  HALTER, Robert J. ,  SLADE, Rachel ,  KLIMOVA, Yevgeniya

IPC分类号： C07D253/08 ,  C07D237/28 ,  C07D237/30 ,  C07D217/22 ,  A61K31/53 ,  A61K31/502 ,  A61K31/472 ,  A61P35/00

CPC分类号： C07D237/34 ,  C07D253/08

摘要： Disclosed are 1-arylamino-phthalazines, 4-arylamino-benzo[d][1,2,3]triazines, and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

公开(公告)号：EP1833511A2

公开(公告)日：2007-09-19

申请号：EP06717342.7

申请日：2006-01-03

申请人： MYRIAD GENETICS, INC. ,  Cytovia, Inc.

发明人： CAI, Sui Xiong ,  ANDERSON, Mark B. ,  WILLARDSEN, Adam ,  SIRISOMA, Nilantha Sudath

IPC分类号： A61K39/395

CPC分类号： C07D239/94 ,  A61K31/395 ,  C07D239/95 ,  C07D401/12

摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs, and in particular to the use of these compounds in treating brain cancer.

公开(公告)号：EP2038041A2

公开(公告)日：2009-03-25

申请号：EP07762175.3

申请日：2007-05-14

申请人： Myriad Genetics, Inc.

发明人： BAJJI, Ashok C. ,  KIM, Se-ho ,  MARKOVITZ, Benjamin ,  TROVATO, Richard ,  TANGALLAPALLY, Rajendra ,  ANDERSON, Mark B. ,  WETTSTEIN, Daniel ,  SHENDEROVICH, Mark ,  VANECKO, John A.

IPC分类号： B01D46/10

CPC分类号： A61K31/52 ,  A61K31/522 ,  C07D473/34

摘要： Compounds of the formula (I) (II) (III) in which A is chosen from a substituted or unsubstituted aryl, heteroaryl, heterocyclic, or carbocyclic group! B is chosen from a substituted or unsubstituted aryl, heteroaryl, heterocyclic, or carbocyclic group Rl is chosen from hydro, alkyl, aryl, heteroaryl, amino, halo, sulfur, and thioalkyl.

公开(公告)号：EP1809601A2

公开(公告)日：2007-07-25

申请号：EP05802834.1

申请日：2005-10-04

申请人： MYRIAD GENETICS, INC.

发明人： SLADE, Rachel ,  KLIMOVA, Yevgeniya ,  HALTER, Robert J. ,  YUNGAI, Ashantai J. ,  WEINER, Warren S. ,  WALTON, Ruth J. ,  WILLARDSEN, Jon Adam ,  ANDERSON, Mark B. ,  ZAVITZ, Kenton

IPC分类号： C07D209/04 ,  A61K31/404

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D417/04

摘要： The invention provides novel compounds useful for the treatment of neurodegenerative disorders including Alzheimer's disease and dementia. The compounds have a substituents chosen from -L-C(=O)OH, -L-CH=CHC(=O)OH, -L-C(=O)NH2, -L-C(=O)NH(C1-3 alkyl), -L-C(=O)N(C1-3 alkyl)2, -L-S(=O)2(C1-3alkyl), -L-S(=O)2NH2, -L-S(=O)2N(C1-3 alkyl)2, -L-S(=O)2NH(C1-3 alkyl), -L-C(=O)NHOH, -L-C(=O)CH2NH2, -L-C(=O)CH2OH, -L-C(=O)CH2SH, -L-C(=O)NHCN, -L-NHC(=O)ORo, -L-C(=O)NHRo, -L-NH(C=O)NHRo, -L-C(=O)N(Ro)2, -L-NH(C=O)N(Ro)2, -L-sulfo, -L-(2,6 difluorophenol), -L-phosphono, and -L-tetrazolyl, where L is a linker.