公开(公告)号：EP2080006A1

公开(公告)日：2009-07-22

申请号：EP07844132.6

申请日：2007-10-11

申请人： Massachusetts Institute of Technology

发明人： BABCOCK, Kenneth ,  BURG, Thomas ,  GODIN, Michel ,  MANALIS, Scott

IPC分类号： G01N15/10

CPC分类号： G01N15/00 ,  G01N5/00 ,  G01N9/002 ,  G01N15/0255 ,  G01N15/10 ,  G01N15/1012 ,  G01N2015/003 ,  G01N2015/1043 ,  G01N2015/1087

摘要： Method for measuring a target particle property. A suspended microchannel resonator is calibrated to determine the relationship between a detected mass and a resonance frequency shift of the resonator. The target particle is suspended in a fluid and introduced into the resonator, and the resonator frequency shift due to the particle is measured. Target particle mass is calculated from the resonator frequency shift, the target particle density, and the fluid density. A target particle property such as size or volume is determined from the calculated target particle mass.

公开(公告)号：EP1718728A2

公开(公告)日：2006-11-08

申请号：EP04809782.8

申请日：2004-09-22

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： MANALIS, Scott ,  BURG, Thomas

IPC分类号： C12M1/34 ,  C12M1/36 ,  C12M1/38 ,  C12M3/00 ,  G01N15/06 ,  G01N21/00 ,  G01N25/18 ,  G01N27/00 ,  G01N27/02 ,  G01N27/06 ,  G01N27/12 ,  G01N31/22 ,  G01N33/00

CPC分类号： B01L3/502707 ,  B01L3/5027 ,  B01L2200/12 ,  B01L2300/0627 ,  B01L2400/0421 ,  B81B7/0061 ,  B81B7/007 ,  B81B2201/0214 ,  B81C1/00071 ,  B81C1/00206 ,  G01N33/54373 ,  H01L2224/48091 ,  H01L2224/48465 ,  H01L2924/00014 ,  H01L2924/00

摘要： An apparatus for detecting an analyte in solution that has a suspended beam containing at least one microfluidic channel containing a capture ligand that bonds to or reacts with an analyte. The apparatus also includes at least one detector for measuring a change in the beam upon binding or reaction of the analyte. A method of making the suspended microfluidic channels is disclosed, as well as, a method of integrating the microfluidic device with conventional microfluidics having larger sample fluid channels.

摘要翻译： 一种用于检测溶液中分析物的装置，其具有包含至少一个含有与分析物结合或与分析物反应的捕获配体的至少一个微流体通道的悬浮梁。 该装置还包括至少一个检测器，用于在分析物的结合或反应时测量束的变化。 公开了制备悬浮微流体通道的方法，以及将微流体装置与具有较大样品流体通道的常规微流体整合的方法。

公开(公告)号：EP2080006B1

公开(公告)日：2016-12-07

申请号：EP07844132.6

申请日：2007-10-11

申请人： Massachusetts Institute of Technology ,  Affinity Biosensors, LLC

发明人： BABCOCK, Kenneth ,  BURG, Thomas ,  GODIN, Michel ,  MANALIS, Scott

IPC分类号： G01N15/10 ,  G01N5/00 ,  G01N9/00

CPC分类号： G01N15/00 ,  G01N5/00 ,  G01N9/002 ,  G01N15/0255 ,  G01N15/10 ,  G01N15/1012 ,  G01N2015/003 ,  G01N2015/1043 ,  G01N2015/1087