公开(公告)号：EP3039465A1

公开(公告)日：2016-07-06

申请号：EP14786509.1

申请日：2014-10-21

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives ,  California Institute of Technology

发明人： DURAFFOURG, Laurent ,  HENTZ, Sébastien ,  ROUKES, Mickael Lee

IPC分类号： G02B6/12 ,  G01H9/00 ,  G02B6/35 ,  G02B6/293

CPC分类号： G02B6/12007 ,  G01D5/266 ,  G01D5/268 ,  G01D5/35312 ,  G01G3/165 ,  G01H9/00 ,  G01N2015/1043 ,  G02B6/1225 ,  G02B6/29343 ,  G02B6/29395 ,  G02B6/3536

摘要： An optomechanical device with mechanical elements and optical filters for actuating and/or detecting movement of the elements, including a support, and on the support: an array of mechanical elements anchored to the support and configured to move with respect thereto, and an actuating and/or detection device actuating the elements and/or detecting movement of the elements or frequency variations of the movement. The actuating and/or detection device includes an array of optical filters. Each filter resonates at a particular wavelength and is coupled to one of the elements. The actuating and/or detecting device is positioned in vicinity of all or some of the elements, between the elements and the support. The optical filters are fixed with respect to the support and the mechanical elements and the optical filters are superimposed.

公开(公告)号：EP2959274A2

公开(公告)日：2015-12-30

申请号：EP13774350.6

申请日：2013-09-27

申请人： California Institute of Technology

发明人： ROUKES, Michael L. ,  SADER, John E. ,  KELBER, Scott I. ,  HANAY, Mehmet Selim

IPC分类号： G01G3/16 ,  G01N5/02

CPC分类号： H01J49/26 ,  G01G3/16 ,  G01N5/02 ,  G01N15/10 ,  G01N2015/0038 ,  G01N2015/1043

摘要： The spatial distribution of mass within an individual analyte can be imaged - in real time and with molecular-scale resolution - when it adsorbs onto a nanomechanical resonator. Each single-molecule adsorption event induces discrete, time-correlated perturbations to the modal frequencies of the device. By continuous monitoring of multiple vibrational modes, the spatial moments of mass distribution can be deduced for individual analytes, one-by-one, as they adsorb. This new method was validated for inertial imaging using both experimental multimode frequency-shift data and finite-element simulations - to analyze the inertial mass, position-of-adsorption, and the shape of individual analytes. Unlike conventional imaging, the spatial resolution of nanomechanical inertial imaging is not limited by wavelength-dependent diffraction phenomena; instead frequency fluctuation processes determine the ultimate attainable resolution. Advanced NEMS devices can provide atomic-scale resolution.

公开(公告)号：EP2080006A1

公开(公告)日：2009-07-22

申请号：EP07844132.6

申请日：2007-10-11

申请人： Massachusetts Institute of Technology

发明人： BABCOCK, Kenneth ,  BURG, Thomas ,  GODIN, Michel ,  MANALIS, Scott

IPC分类号： G01N15/10

CPC分类号： G01N15/00 ,  G01N5/00 ,  G01N9/002 ,  G01N15/0255 ,  G01N15/10 ,  G01N15/1012 ,  G01N2015/003 ,  G01N2015/1043 ,  G01N2015/1087

摘要： Method for measuring a target particle property. A suspended microchannel resonator is calibrated to determine the relationship between a detected mass and a resonance frequency shift of the resonator. The target particle is suspended in a fluid and introduced into the resonator, and the resonator frequency shift due to the particle is measured. Target particle mass is calculated from the resonator frequency shift, the target particle density, and the fluid density. A target particle property such as size or volume is determined from the calculated target particle mass.

公开(公告)号：EP3264065A1

公开(公告)日：2018-01-03

申请号：EP17178194.1

申请日：2017-06-27

申请人： Honeywell International Inc.

发明人： COLE, Barrett E. ,  COSTELLO, Robert P.

IPC分类号： G01N15/02 ,  G01N21/53 ,  G01N15/14 ,  F21V7/08 ,  G01N21/47

CPC分类号： G01N15/1434 ,  G01N15/0205 ,  G01N15/06 ,  G01N21/53 ,  G01N2015/1043 ,  G01N2021/4707 ,  G01N2201/0637 ,  G01N2201/0642

摘要： Devices and methods for detecting particulate matter are described herein. One device includes a laser, a reflector, an ellipsoidal reflector, and a detector, wherein the laser is configured to emit a beam, the reflector is configured to reflect the beam toward the ellipsoidal reflector, and the ellipsoidal reflector has a first focal region located on a path of the reflected beam, and a second focal region located at a surface of the detector.

摘要翻译： 这里描述了用于检测颗粒物质的装置和方法。 一种装置包括激光器，反射器，椭球反射器和检测器，其中激光器被配置为发射光束，反射器被配置为朝向椭圆反射器反射光束，并且椭圆反射器具有位于第一焦点区域 在反射光束的路径上，以及位于检测器表面处的第二焦点区域。

公开(公告)号：EP2866020A1

公开(公告)日：2015-04-29

申请号：EP14189689.4

申请日：2014-10-21

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives

发明人： Hentz, Sébastien ,  Ernst, Thomas

IPC分类号： G01N5/02 ,  G01N29/02 ,  G01L9/00 ,  H03H9/24

CPC分类号： G01N15/10 ,  G01L1/148 ,  G01L1/18 ,  G01L1/2293 ,  G01N5/02 ,  G01N29/022 ,  G01N29/036 ,  G01N2015/1043 ,  G01N2291/02466 ,  G01N2291/0256

摘要： Dispositif de détection électromécanique, notamment pour la détection gravimétrique, et procédé de fabrication du dispositif.
Le dispositif de détection électromécanique comprend un support (4) comportant une face définissant un plan (6), au moins une poutre (8) apte à se déplacer par rapport au support, et des moyens (10) de détection du déplacement de la poutre, fournissant un signal fonction du déplacement. La poutre est ancrée au support par une extrémité, et sensiblement perpendiculaire audit plan, et l'autre extrémité de la poutre comporte au moins une zone d'accueil (12), pour recevoir une ou plusieurs particules (14) provoquant ou modifiant le déplacement de la poutre, en vue de déterminer au moins une propriété physique de la particule ou des particules à partir du signal. Selon l'invention, les moyens de détection sont situés entre la zone d'accueil et le support.

公开(公告)号：EP2574885B1

公开(公告)日：2014-04-09

申请号：EP12186095.1

申请日：2012-09-26

申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives

发明人： Blanco-Gomez, Gérald ,  Agache, Vincent

IPC分类号： G01N5/00

CPC分类号： G01G3/16 ,  G01N5/02 ,  G01N15/02 ,  G01N15/1484 ,  G01N2015/1043

公开(公告)号：EP0871640A4

公开(公告)日：2002-04-17

申请号：EP96912538

申请日：1996-04-03

申请人： UNIV NEW YORK

发明人： SCHWARTZ DAVID C

IPC分类号： C12N15/09 ,  C12M1/00 ,  C12Q1/68 ,  G01N15/10 ,  G01N15/14 ,  C07H19/00 ,  C07H21/00 ,  G01N27/447

CPC分类号： C12Q1/6806 ,  C12Q1/6834 ,  C12Q1/6841 ,  C12Q1/6869 ,  G01N2015/0038 ,  G01N2015/1043 ,  G01N2015/105 ,  G01N2015/149 ,  G01N2015/1495 ,  C12Q2565/601 ,  C12Q2527/125

摘要： Disclosed is a method for measuring physical characteristics, such as size and weight, of individual molecules. The method involves subjecting a deformable or nondeformable molecule to an external force which causes conformational or positional changes and then measuring these changes. Preferred ways to measure such changes include: 1) determining the rate at which a molecule becomes oriented in a new direction when the direction of the perturbing force is changed, 2) determining the rate at which a deformable molecule returns to a relaxed state after termination of the external force, 3) determining the rate at which a molecule rotates, 4) measuring the length of a molecule when it is partially stretched, or 5) measuring the diameter of a spherical or ellipsoidal molecule. These measurements can be performed by use of a light microscope connected to an image processor or spectroscopic device. The invention is particularly useful for measuring polymeric molecules such as nucleic acids and can be used to determine size and map location of restriction digests.

公开(公告)号：EP3444837A1

公开(公告)日：2019-02-20

申请号：EP17710586.3

申请日：2017-02-22

申请人： Nanodreams, S.L. ,  Consejo Superior de Investigaciones Cientificas

发明人： MALVAR VIDAL, Oscar ,  RUZ MARTINEZ, José Jaime ,  MONTEIRO KOSAKA, Priscila ,  CALLEJA GOMEZ, Montserrat ,  TAMAYO DE MIGUEL, Francisco Javier

IPC分类号： H01J49/26 ,  G01G3/16 ,  G01N5/02

CPC分类号： G01G3/16 ,  G01N15/1056 ,  G01N2015/0038 ,  G01N2015/1043 ,  H01J49/0036 ,  H01J49/26

摘要： A method for obtaining the absorption position, mass and rigidity of a particle deposited on the surface of a resonator based on the relative change in the resonance frequency of said resonator in 3 or 4 flexural vibration modes. The rigidity of the particles is of great interest in the study of cells and other biological compounds that change state without significantly changing the mass.

公开(公告)号：EP2080006B1

公开(公告)日：2016-12-07

申请号：EP07844132.6

申请日：2007-10-11

申请人： Massachusetts Institute of Technology ,  Affinity Biosensors, LLC

发明人： BABCOCK, Kenneth ,  BURG, Thomas ,  GODIN, Michel ,  MANALIS, Scott

IPC分类号： G01N15/10 ,  G01N5/00 ,  G01N9/00

CPC分类号： G01N15/00 ,  G01N5/00 ,  G01N9/002 ,  G01N15/0255 ,  G01N15/10 ,  G01N15/1012 ,  G01N2015/003 ,  G01N2015/1043 ,  G01N2015/1087

公开(公告)号：EP3025142A1

公开(公告)日：2016-06-01

申请号：EP14750400.5

申请日：2014-07-18

申请人： National Oilwell Varco, L.P.

发明人： LARSON, Thomas Robert

IPC分类号： G01N9/10 ,  G01N9/34 ,  G01N15/02 ,  G01N15/10

CPC分类号： G01N9/00 ,  G01N9/10 ,  G01N9/34 ,  G01N15/0205 ,  G01N15/0211 ,  G01N15/10 ,  G01N2015/1043 ,  G01N2015/1075

摘要： A system includes a particulate material sample that contains a fluid medium and a plurality of particles dispersed in the fluid medium. The system further includes a particle analysis apparatus having a sample cell and sample delivery means for delivering the particulate material sample to the sample cell, wherein the particle analysis apparatus is adapted to obtain particle information on at least one particle in that particulate material sample while the at least one particle is in the sample cell. Furthermore, the system also includes fluid manipulation means for manipulating movement of the fluid medium while the particle analysis apparatus is obtaining the particle information on the at least one particle, and a data processing apparatus that is adapted to determine a specific gravity of the at least one particle based on the obtained particle information.