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    METHOD FOR INHIBITING THE DEVELOPMENT OF TERATOMA
    1.
    发明公开
    METHOD FOR INHIBITING THE DEVELOPMENT OF TERATOMA 审中-公开
    抑制TERATOMA发展的方法

    公开(公告)号：EP2055772A1

    公开(公告)日：2009-05-06

    申请号：EP07806111.6

    申请日：2007-08-27

    申请人： Matsumoto Dental University

    发明人： YAMAKI, Mariko ,  OZAWA, Hidehiro ,  EBINA, Satoshi ,  ASASHIMA, Makoto

    IPC分类号： C12N5/06 ,  A61L27/00

    CPC分类号： C12N5/0606 ,  A61L27/3834 ,  C12N5/0603 ,  C12N2533/54

    摘要： The present invention provides a method for suppressing generation of a teratoma of an undifferentiated cell, preferably an ES cell. A biological material obtainable by the method and a therapeutic method for transplanting the biological material into a subject are also provided.
    An undifferentiated cell, in particular, preferably an ES cell is cultured to produce an increased embryoid body-like and the embryoid body-like is cultured for at least one week on, and adhered to, a three-dimensional solid type-I collagen carrier or an analogue thereof. Furthermore, a biological material is obtained thereby and the biological material is transplanted into a mammalian subject.

    摘要翻译： 本发明提供抑制未分化细胞，优选ES细胞的畸胎瘤的产生的方法。 还提供了通过将生物材料移植入受试者的方法和治疗方法获得的生物材料。 未分化的细胞，特别是优选ES细胞被培养以产生增加的胚状体样，并且胚状体样培养至少一周并粘附到三维固体I型胶原蛋白载体 或其类似物。 此外，由此获得生物材料并将生物材料移植到哺乳动物受试者中。

    METHOD FOR PRODUCTION OF HAIR AND BIOMATERIAL
    2.
    发明公开
    METHOD FOR PRODUCTION OF HAIR AND BIOMATERIAL 有权
    VERFAHREN ZUR HERSTELLUNG VON HAAR UND BIOMATERIAL

    公开(公告)号：EP2119769A1

    公开(公告)日：2009-11-18

    申请号：EP08710780.1

    申请日：2008-02-05

    申请人： Matsumoto Dental University

    发明人： OZAWA, Hidehiro ,  YAMAKI, Mariko ,  ASASHIMA, Makoto ,  EBINA, Satoshi

    IPC分类号： C12N5/06 ,  A61L27/00 ,  A61P17/14 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50

    CPC分类号： G01N33/5082 ,  C12N5/0627 ,  C12N2501/105 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2506/02 ,  C12N2506/1361 ,  C12N2533/54

    摘要： A method of making a hair, including a step of culturing an undifferentiated cell of a mammal to produce an embryoid body and a step of further culturing the embryoid body is provided, wherein the culturing step is to culture the embryoid body on a three-dimensional matrix for 5 to 12 days. Furthermore, a biological material obtainable by the method of making a hair as described above is provided. Moreover, a biological material for a screening system of evaluating a medical product or the like, obtainable by utilizing the method of making a hair as described above is provided.

    摘要翻译： 提供了一种制备头发的方法，包括培养哺乳动物的未分化细胞以产生胚状体的步骤和进一步培养胚状体的步骤，其中培养步骤是将胚状体在三维 基质5至12天。 此外，提供了可通过如上所述制造头发的方法获得的生物材料。 此外，提供了通过利用上述制造头发的方法获得的用于评估医疗产品等的筛选系统的生物材料。