公开(公告)号：EP1538200B1

公开(公告)日：2017-04-05

申请号：EP03752940.1

申请日：2003-05-22

申请人： Matsutani Chemical Industry Co., Ltd. ,  Kagawa University

发明人： IZUMORI, Ken ,  TOKUDA, Masaaki ,  ITANO, Toshifumi ,  MIYAMOTO, Osamu ,  ISHIDA, Toshihiko ,  MURAO, Koji ,  TASAKA, Taizo ,  MUNEUCHI, Gan ,  YAMAGUCHI, Fuminori ,  TANAKA, Terukazu ,  HOSSAIN, Mohammad, Akram ,  UEKI, Masaaki ,  HIROOKA, Kazuyuki ,  TAMINATO, Tomohiko ,  TSUSAKI, Keiji ,  TAKAHASHI, Takeo ,  NAGATA, Mitsuhiro ,  ISHIDA, Yutaka

IPC分类号： A61K8/60 ,  A61Q19/00 ,  A23L29/30 ,  A61K31/7004 ,  A23L33/10

CPC分类号： A61Q19/00 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A61K8/60 ,  A61K31/7004

摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.

公开(公告)号：EP3115052A1

公开(公告)日：2017-01-11

申请号：EP16183213.4

申请日：2003-05-22

申请人： Matsutani Chemical Industry Co., Ltd. ,  Kagawa University

发明人： IZUMORI, Ken ,  TOKUDA, Masaaki ,  ITANO, Toshifumi ,  MIYAMOTO, Osamu ,  ISHIDA, Toshihiko ,  MURAO, Koji ,  TASAKA, Taizo ,  MUNEUCHI, Gan ,  YAMAGUCHI, Fuminori ,  TANAKA, Terukazu ,  HOSSAIN, Mohammad, Akram ,  UEKI, Masaaki ,  HIROOKA, Kazuyuki ,  TAMINATO, Tomohiko ,  TSUSAKI, Keiji ,  TAKAHASHI, Takeo ,  NAGATA, Mitsuhiro ,  ISHIDA, Yutaka

IPC分类号： A61K31/7004 ,  A61P9/10 ,  A61K8/60 ,  A61Q19/00 ,  A23L29/30 ,  A23L33/10

CPC分类号： A61Q19/00 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A61K8/60 ,  A61K31/7004

摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.

摘要翻译： 利用稀有糖类的生理活性的方法，其中用稀有糖类处理生理活性敏感性细胞以改变细胞的功能。 作为活性成分含有引入生理活性敏感性细胞的稀有糖类并具有改变细胞功能的作用的组合物。 细胞是人类细胞。 组合物是功能性食品，药物或化妆品。 罕见的糖是属于醛糖和/或酮糖的稀有糖。 醛糖是D-丙氨酸，细胞选自癌细胞增殖抑制活性敏感细胞和活性氧生成抑制活性敏感细胞。 酮糖是D-psicose，细胞选自趋化因子分泌抑制活性敏感细胞，小胶质细胞迁移抑制活性敏感细胞和降血糖活性敏感细胞。

公开(公告)号：EP3175858B1

公开(公告)日：2019-08-21

申请号：EP17150941.7

申请日：2003-05-22

申请人： Matsutani Chemical Industry Co., Ltd. ,  Kagawa University

发明人： IZUMORI, Ken ,  TOKUDA, Masaaki ,  ITANO, Toshifumi ,  MIYAMOTO, Osamu ,  ISHIDA, Toshihiko ,  MURAO, Koji ,  TASAKA, Taizo ,  MUNEUCHI, Gan ,  YAMAGUCHI, Fuminori ,  TANAKA, Terukazu ,  HOSSAIN, Mohammad Akram ,  UEKI, Masaaki ,  HIROOKA, Kazuyuki ,  TAMINATO, Tomohiko ,  TSUSAKI, Keiji ,  TAKAHASHI, Takeo ,  NAGATA, Mitsuhiro ,  ISHIDA, Yutaka

IPC分类号： A61K31/7004 ,  A61P35/00

公开(公告)号：EP3115052B1

公开(公告)日：2019-08-21

申请号：EP16183213.4

申请日：2003-05-22

申请人： Matsutani Chemical Industry Co., Ltd. ,  Kagawa University

发明人： IZUMORI, Ken ,  TOKUDA, Masaaki ,  ITANO, Toshifumi ,  MIYAMOTO, Osamu ,  ISHIDA, Toshihiko ,  MURAO, Koji ,  TASAKA, Taizo ,  MUNEUCHI, Gan ,  YAMAGUCHI, Fuminori ,  TANAKA, Terukazu ,  HOSSAIN, Mohammad, Akram ,  UEKI, Masaaki ,  HIROOKA, Kazuyuki ,  TAMINATO, Tomohiko ,  TSUSAKI, Keiji ,  TAKAHASHI, Takeo ,  NAGATA, Mitsuhiro ,  ISHIDA, Yutaka

IPC分类号： A61K31/7004 ,  A61P9/10 ,  A61K8/60 ,  A61Q19/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23L5/00

公开(公告)号：EP3175858A1

公开(公告)日：2017-06-07

申请号：EP17150941.7

申请日：2003-05-22

申请人： Matsutani Chemical Industry Co., Ltd. ,  Kagawa University

发明人： IZUMORI, Ken ,  TOKUDA, Masaaki ,  ITANO, Toshifumi ,  MIYAMOTO, Osamu ,  ISHIDA, Toshihiko ,  MURAO, Koji ,  TASAKA, Taizo ,  MUNEUCHI, Gan ,  YAMAGUCHI, Fuminori ,  TANAKA, Terukazu ,  HOSSAIN, Mohammad Akram ,  UEKI, Masaaki ,  HIROOKA, Kazuyuki ,  TAMINATO, Tomohiko ,  TSUSAKI, Keiji ,  TAKAHASHI, Takeo ,  NAGATA, Mitsuhiro ,  ISHIDA, Yutaka

IPC分类号： A61K31/7004 ,  A61P35/00

CPC分类号： A61Q19/00 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A61K8/60 ,  A61K31/7004

摘要： A composition comprising D-allose as an active ingredient for use in the treatment of liver cancer or skin cancer in a patient by administering said composition to said patient.

摘要翻译： 包含D-阿洛糖作为活性成分的组合物，用于通过将所述组合物给予所述患者来治疗患者的肝癌或皮肤癌。

公开(公告)号：EP1905442B1

公开(公告)日：2011-01-05

申请号：EP06781323.8

申请日：2006-07-20

申请人： TEIKOKU SEIYAKU CO., LTD. ,  National University Corporation Kagawa University

发明人： NAGATA, Mitsuhiro

IPC分类号： A61K31/7004 ,  A23L1/30 ,  A61P29/00 ,  C07H3/02

CPC分类号： A61K31/7004 ,  A23L33/10 ,  A23V2002/00 ,  A23V2200/308

摘要： [PROBLEMS] To control neuropathic pain produced by various mechanisms. [MEANS FOR SOLVING PROBLEMS] Disclosed is a composition for elimination, relief or reduction of neuropathic pain comprising, as an active ingredient, at least one substance selected from the group consisting of D-allose, a derivative of D-allose, D-psicose and a derivative of D-psicose preferably in an amount of 0.01 to 90% by weight. The composition may comprise a mixture of D-allose and/or a derivative thereof and D-psicose and/or a derivative thereof at a ratio of 1:1 to 10:1. The neuropathic pain may be one induced by a disease selected from the group consisting of trigeminal neuralgia, postoperative pain, periodontitis, gingivitis, gingivostomatitis, oral ulcer, herpes zoster, postherpetic neuralgia, diabetic neuritis, causalgia, phantom limb pain and malignant tumor. Also disclosed is use of the composition for elimination, relief or reduction of neuropathic pain by administering the composition to a patient with neuropathic pain in such an amount that 0.01 to 100 g of the at least one substance can be taken by the patient per day.

公开(公告)号：EP1538200A1

公开(公告)日：2005-06-08

申请号：EP03752940.1

申请日：2003-05-22

申请人： Fushimi Pharmaceutical Company, Limited ,  Teikoku Seiyaku Co., Ltd. ,  Kagawa University ,  Shikoku Research Institute Incorporated ,  KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

发明人： IZUMORI, Ken ,  TOKUDA, Masaaki ,  ITANO, Toshifumi ,  MIYAMOTO, Osamu ,  ISHIDA, Toshihiko ,  MURAO, Koji ,  TASAKA, Taizo ,  MUNEUCHI, Gan ,  YAMAGUCHI, Fuminori ,  TANAKA, Terukazu ,  HOSSAIN, Mohammad, Akram ,  UEKI, Masaaki ,  HIROOKA, Kazuyuki ,  TAMINATO, Tomohiko ,  TSUSAKI, Keiji ,  TAKAHASHI, Takeo ,  NAGATA, Mitsuhiro ,  ISHIDA, Yutaka

IPC分类号： C12N5/08 ,  A23L1/30 ,  A61K7/00 ,  A61K31/7004

CPC分类号： A61Q19/00 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A61K8/60 ,  A61K31/7004

摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.

摘要翻译： 利用一种罕见糖的生理活性的方法，worin生理活性敏感细胞与罕见糖处理，以改变细胞的功能。 被引入生理活性敏感的细胞，并且对修饰细胞功能的影响包含组合物，如在，稀有糖类活性成分全部。 该细胞是人类细胞。 该组合物是一种功能性食品，药物或化妆品。 稀有糖类是属于醛糖和/或酮糖罕见的糖。 醛糖是D-阿洛糖，并将细胞选自癌细胞增殖抑制活性敏感的细胞和活性氧产生抑制活性敏感的细胞的选择。 所述酮糖是D-阿洛酮糖，并且所述细胞选自趋化因子分泌的抑制活性敏感的细胞，小神经胶质细胞迁移抑制活性敏感的细胞，和低血糖活性敏感的细胞的选择。

公开(公告)号：EP1905442A1

公开(公告)日：2008-04-02

申请号：EP06781323.8

申请日：2006-07-20

申请人： TEIKOKU SEIYAKU CO., LTD. ,  National University Corporation Kagawa University

发明人： NAGATA, Mitsuhiro

IPC分类号： A61K31/7004 ,  A23L1/30 ,  A61P29/00 ,  C07H3/02

CPC分类号： A61K31/7004 ,  A23L33/10 ,  A23V2002/00 ,  A23V2200/308

摘要： PROBLEMS To control neuropathic pain produced by various mechanisms. [MEANS FOR SOLVING PROBLEMS] Disclosed is a composition for elimination, relief or reduction of neuropathic pain comprising, as an active ingredient, at least one substance selected from the group consisting of D-allose, a derivative ofD-allose, D-psicose and a derivative of D-psicose preferably in an amount of 0.01 to 90% by weight. The composition may comprise a mixture of D-allose and/or a derivative thereof and D-psicose and/or a derivative thereof at a ratio of 1:1 to 10:1. The neuropathic pain may be one induced by a disease selected from the group consisting of trigeminal neuralgia, postoperative pain, periodontitis, gingivitis, gingivostomatitis, oral ulcer, herpes zoster, postherpetic neuralgia, diabetic neuritis, causalgia, phantom limb pain and malignant tumor. Also disclosed is use of the composition for elimination, relief or reduction of neuropathic pain by administering the composition to a patient with neuropathic pain in such an amount that 0.01 to 100 g of the at least one substance can be taken by the patient per day.

摘要翻译： 问题为了控制各种机制产生的神经性疼痛。 用于解决问题的手段公开了用于消除，缓解或减少神经性疼痛的组合物，其包含作为活性成分的至少一种选自D-阿洛糖，D-阿洛糖衍生物，D-灵芝糖和 D-木糖的衍生物优选为0.01〜90重量％。 组合物可以以1:1至10:1的比例包含D-丙氨酸和/或其衍生物和D-灵芝蛋白和/或其衍生物的混合物。 神经性疼痛可以是由选自三叉神经痛，术后疼痛，牙周炎，牙龈炎，牙龈炎，口腔溃疡，带状疱疹，带状疱疹后神经痛，糖尿病性神经炎，灼痛，幻肢疼痛和恶性肿瘤的疾病诱发的疾病。 还公开了通过将组合物给予患有神经性疼痛的患者，使得该组合物用于消除，缓解或减少神经性疼痛，其用量可由患者每天服用0.01至100g的至少一种物质。