公开(公告)号：EP2056806A2

公开(公告)日：2009-05-13

申请号：EP07786683.8

申请日：2007-08-14

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. ,  Heinrich-Heine-Universität Düsseldorf

发明人： FISCHER, Gunter ,  SCHIENE-FISCHER, Cordelia ,  DAUM, Sebastian ,  KÜLLERTZ, Gerhard ,  BRAUN, Manfred ,  FEAUX DE LACROIX, Boris

IPC分类号： A61K31/12 ,  A61K31/136 ,  A61K31/343 ,  A61P37/02 ,  A61P31/00 ,  A61P33/00 ,  A61P17/06 ,  A61P35/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/10 ,  A61P19/02 ,  A61P25/28 ,  A61P25/16 ,  A61P25/00 ,  A61P3/10 ,  A61P9/00 ,  A61P13/00

CPC分类号： A61K31/12 ,  A61K31/136 ,  A61K31/343 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/471 ,  Y02A50/475 ,  Y02A50/481 ,  Y02A50/483

摘要： The present invention relates to the use of certain spiro, ketone and carboxylic acid compounds for the inhibition of the peptidyl-prolyl cis/trans isomerase activity of cyclophilins and the use of these compounds for the production of a cosmetic or pharmaceutical composition for the promotion of hair growth or for the treatment or prevention of inflammatory autoimmune diseases, of diseases caused by fungi, of bacterial infections, of viral infections, of diseases caused by parasites, protozoa or worms, of cancer, of diseases of cells, of fibrosing diseases, and of non-neoplastic changes and diseases which are attributable to prions and changes in the structure and function of cellular proteins and cells.

公开(公告)号：EP1706504A1

公开(公告)日：2006-10-04

申请号：EP05706982.5

申请日：2005-01-24

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： FISCHER, Gunter ,  EDLICH, Frank ,  WEIWAD, Matthias ,  JARCZOWSKI, Franziska ,  KÜLLERTZ, Gerhard

IPC分类号： C12Q1/533

CPC分类号： C12Q1/533 ,  G01N2333/4727 ,  G01N2500/02

摘要： The invention relates to a method for identifying and producing effectors of peptidyl-prolyl cis/trans isomerases which can be activated by calmodulin. The invention also relates to the use of the identified effectors for the production of medicaments, and to screening methods and kits.

公开(公告)号：EP2190430A1

公开(公告)日：2010-06-02

申请号：EP07801885.0

申请日：2007-08-24

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： KÜLLERTZ, Gerhard ,  FISCHER, Gunter ,  RAU, Steffi ,  HUSSE, Britta Erika

IPC分类号： A61K31/45 ,  A61P9/10

CPC分类号： A61K31/45

摘要： The present invention relates to the use of certain derivatives of cycloheximide or the pharmaceutically acceptable salts thereof for the manufacture of a medicament for the treatment or prevention of ischaemias, of cardiopathies, of endothelial disorders, of traumata, of necroses, of pulmonary disorders, of vascular disorders, of forms of shock, of blood flow impairments or of stroke; or for the manufacture of a medicament for the treatment or prevention of diseases caused by ischaemia; or for the manufacture of a composition for the preservation and/or storage of transplants, especially of organs.

公开(公告)号：EP1421106B1

公开(公告)日：2009-01-21

申请号：EP02796249.7

申请日：2002-08-20

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： SCHIENE-FISCHER, Cordelia ,  FISCHER, Gunter ,  HABAZETTL, Judith, Maria ,  KÜLLERTZ, Gerhard

IPC分类号： C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  A61K38/00

CPC分类号： C07K7/56 ,  A61K38/00

摘要： The invention is based on the finding that the cis/trans isomerisation of secondary amide peptide bonds in oligo- and poly-peptides can be catalytically promoted. Said catalysis is furthermore brought about by enzymes called secondary amide peptide bond cis/trans isomerases (APIases). It can be assumed that the APIase activity plays a central role in a number of pathophysiological processes. The invention thus relates to medicaments, comprising substances which inhibit APIase activity.