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公开(公告)号：EP4333822A1
公开(公告)日：2024-03-13
申请号：EP22727767.0
申请日：2022-05-02
发明人： BERGBREDE, Tim , UNGER, Anke , DI LUCREZIA, Raffaella , CHOIDAS, Axel , KLEBL, Bert , NUSSBAUMER, Peter , MENNINGER, Sascha , HABENBERGER, Peter , ZISCHINSKY, Gunther , KOCH, Uwe , SCHRÖDER, Peter , JESTRABOVÁ, Pavla , PALOVÁ-JELÍNKOVÁ, Lenka , DÁNOVÁ, Klára , FALKENBERG-GUSTAFSSON, Maria , ARABANIAN, Laleh , GUSTAFSSON, Claes , LARSSON, Nils-Göran , PALMQVIST, Lars
IPC分类号： A61K31/166 , A61K31/167 , A61K31/4184 , A61K31/437 , A61K31/4412 , A61K31/4439 , A61K31/4523 , A61K31/453 , A61K31/4709 , A61K31/496 , A61K31/502 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/5517 , A61P35/00
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公开(公告)号：EP3303613A1
公开(公告)日：2018-04-11
申请号：EP16725866.4
申请日：2016-05-30
IPC分类号： C12Q1/68
摘要： The present invention relates to methods for detection of nucleotide polymerase activity and methods of detecting compounds that modulate nucleotide polymerase activity, by detecting product formation of the nucleotide polymerase to be tested based on determination of close proximity of two labeled nucleotide probes able to bind the product of the nucleotide polymerase. It is preferred that proximity dependent energy transfer, such as förster resonance energy transfer, between said labeled nucleotide probes is determined. The invention further provides kits comprising components for carrying out the inventive methods for detection of nucleotide polymerase activity.
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4.发明公开METHOD TO DETECT ACTIVITY OF A POLYMERASE 审中-公开VERFAHREN ZUR ERKENNUNG DERAKTIVITÄTEINES POLYMERASE
公开(公告)号：EP3098322A1
公开(公告)日：2016-11-30
申请号：EP15169966.7
申请日：2015-05-29
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q1/48 , C12Q1/68 , C12Q1/6825 , G01N33/542 , G01N33/582 , G01N2333/91245 , C12Q2521/119 , C12Q2565/101
摘要： The present invention relates to methods for detection of nucleotide polymerase activity and methods of detecting compounds that modulate nucleotide polymerase activity, by detecting product formation of the nucleotide polymerase to be tested based on determination of close proximity of two labeled nucleotide probes able to bind the product of the nucleotide polymerase. It is preferred that proximity dependent energy transfer, such as förster resonance energy transfer, between said labeled nucleotide probes is determined. The invention further provides kits comprising components for carrying out the inventive methods for detection of nucleotide polymerase activity.
摘要翻译： 本发明涉及用于检测核苷酸聚合酶活性的方法和检测调节核苷酸聚合酶活性的化合物的方法，通过基于能够结合产物的两个标记的核苷酸探针的紧密度的测定来检测待测试的核苷酸聚合酶的产物形成 的核苷酸聚合酶。 优选确定所述标记的核苷酸探针之间的接近依赖的能量转移，例如förster共振能量转移。 本发明还提供了包含用于实施本发明的用于检测核苷酸聚合酶活性的方法的组分的试剂盒。
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