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公开(公告)号：EP1208209A1
公开(公告)日：2002-05-29
申请号：EP00959219.7
申请日：2000-08-11
申请人： Maxygen, Inc. , Liu, Lu
发明人： KREBBER, Claus , DAVIS, S., Christopher , DELCARDAYRE, Stephen , SELIFONOV, Sergey, A. , HOWARD, Russell
摘要： This invention provides libraries of recombinant derivatizing enzymes that are useful for biocatalytic synthesis of derivatives oforganic molecules, including lead compounds for pharmaceutical use. The recombinant derivatizing enzymes catalyze reactions such as modification or replacement of functional groups on the organicmolecules, or addition of chemical moieties onto preexisting functional groups. The use of recombinant enzyme libraries enables one to obtain enzymes that catalyze the formation of organic molecule derivatives that could not otherwise be made using only naturally occurring enzymes.
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公开(公告)号：EP1196552A2
公开(公告)日：2002-04-17
申请号：EP00944760.8
申请日：2000-06-20
申请人： Maxygen, Inc.
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/21 , A61K39/255 , A61K39/265 , A61K39/29 , A61K2039/5254 , A61K2039/53 , C12N2710/16034 , C12N2710/16334 , C12N2720/12334 , C12N2740/16034 , C12N2760/16134 , C12N2760/18534 , C12N2770/10034 , C12N2770/12034 , C12N2770/20034 , C12N2770/24134 , C12N2770/24161 , C12N2770/32434 , C12N2770/36034 , Y02A50/464 , Y02A50/487 , Y02A50/491
摘要： This invention provides attenuated vaccines, and methods of obtaining attenuated vaccines. The vaccines of the invention include recombinant viral, bacterial, parasite, and other organisms that are evolved to exhibit increased attenuation without loss of effectiveness as a vaccine. The methods involve the creation of libraries of recombinant nucleic acids (e.g., whole or partial genomes, or particular nucleic acids) which are introduced into the vaccine viruses or other organisms, followed by screening and/or selection for those viruses or organisms that are attenuated.
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