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1.发明公开GENERATION OF ANTIBODIES TO TUMOR ANTIGENS AND GENERATION OF TUMOR SPECIFIC COMPLEMENT DEPENDENT CYTOTOXICITY BY ADMINISTRATION OF ONCOLYTIC VACCINIA VIRUS 审中-公开抗体肿瘤抗原的产生和生产由溶瘤病毒疫苗的管理肿瘤特异性补体依赖性细胞毒作用
公开(公告)号：EP2661278A1
公开(公告)日：2013-11-13
申请号：EP12732263.4
申请日：2012-01-04
申请人： Jennerex Inc. , Sillajen, Inc.
发明人： KIRN, David , BELL, John , BREITBACH, Caroline , MOON, Anne , HWANG, Tae-Ho , LEE, Yu Kyoung , KIM, Mi-kyung
IPC分类号： A61K39/12
CPC分类号： A61K39/285 , A61K35/26 , A61K35/76 , A61K35/761 , A61K35/763 , A61K35/768 , A61K39/0011 , A61K39/12 , A61K39/125 , A61K39/145 , A61K39/165 , A61K39/17 , A61K39/205 , A61K39/235 , A61K39/245 , A61K39/395 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/55522 , C07K16/18 , C07K16/30 , C07K2317/14 , C07K2317/734 , C12N7/00 , C12N2710/10034 , C12N2710/16632 , C12N2710/16634 , C12N2710/24034 , C12N2710/24132 , C12N2720/12232 , C12N2750/14034 , C12N2760/16034 , C12N2760/18134 , C12N2760/18434 , C12N2760/18734 , C12N2760/20034 , C12N2760/20232 , C12N2770/32034 , C12N2770/32334 , C12N2770/36034 , G01N33/574
摘要： The present invention relates to methods and compositions for use in inducing tumor-specific antibody mediated complement-dependent cytotoxic response in an animal having a tumor comprising administering to said animal a composition comprising a replication competent oncolytic virus wherein administration of the composition induces in the animal production of antibodies that mediate a CDC response specific to said tumor.
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2.发明公开GENERATION OF ANTIBODIES TO TUMOR ANTIGENS AND GENERATION OF TUMOR SPECIFIC COMPLEMENT DEPENDENT CYTOTOXICITY BY ADMINISTRATION OF ONCOLYTIC VACCINIA VIRUS 审中-公开抗体肿瘤抗原的产生和生产由溶瘤病毒疫苗的管理肿瘤特异性补体依赖性细胞毒作用
公开(公告)号：EP2661278A4
公开(公告)日：2015-10-07
申请号：EP12732263
申请日：2012-01-04
发明人： KIRN DAVID , BELL JOHN , BREITBACH CAROLINE , MOON ANNE , HWANG TAE-HO , LEE YU KYOUNG , KIM MI-KYUNG
CPC分类号： A61K39/285 , A61K35/26 , A61K35/76 , A61K35/761 , A61K35/763 , A61K35/768 , A61K39/0011 , A61K39/12 , A61K39/125 , A61K39/145 , A61K39/165 , A61K39/17 , A61K39/205 , A61K39/235 , A61K39/245 , A61K39/395 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/55522 , C07K16/18 , C07K16/30 , C07K2317/14 , C07K2317/734 , C12N7/00 , C12N2710/10034 , C12N2710/16632 , C12N2710/16634 , C12N2710/24034 , C12N2710/24132 , C12N2720/12232 , C12N2750/14034 , C12N2760/16034 , C12N2760/18134 , C12N2760/18434 , C12N2760/18734 , C12N2760/20034 , C12N2760/20232 , C12N2770/32034 , C12N2770/32334 , C12N2770/36034 , G01N33/574
摘要： The present invention relates to methods and compositions for use in inducing tumor-specific antibody mediated complement-dependent cytotoxic response in an animal having a tumor comprising administering to said animal a composition comprising a replication competent oncolytic virus wherein administration of the composition induces in the animal production of antibodies that mediate a CDC response specific to said tumor.
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公开(公告)号：EP1196552A2
公开(公告)日：2002-04-17
申请号：EP00944760.8
申请日：2000-06-20
申请人： Maxygen, Inc.
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/21 , A61K39/255 , A61K39/265 , A61K39/29 , A61K2039/5254 , A61K2039/53 , C12N2710/16034 , C12N2710/16334 , C12N2720/12334 , C12N2740/16034 , C12N2760/16134 , C12N2760/18534 , C12N2770/10034 , C12N2770/12034 , C12N2770/20034 , C12N2770/24134 , C12N2770/24161 , C12N2770/32434 , C12N2770/36034 , Y02A50/464 , Y02A50/487 , Y02A50/491
摘要： This invention provides attenuated vaccines, and methods of obtaining attenuated vaccines. The vaccines of the invention include recombinant viral, bacterial, parasite, and other organisms that are evolved to exhibit increased attenuation without loss of effectiveness as a vaccine. The methods involve the creation of libraries of recombinant nucleic acids (e.g., whole or partial genomes, or particular nucleic acids) which are introduced into the vaccine viruses or other organisms, followed by screening and/or selection for those viruses or organisms that are attenuated.
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公开(公告)号：EP2931318A4
公开(公告)日：2016-07-20
申请号：EP13863143
申请日：2013-12-13
IPC分类号： A61K39/00 , A61K31/7088 , A61K39/12 , A61K39/21 , A61K39/38 , A61K48/00 , C07K14/47 , C07K16/10 , C07K16/32 , C12N7/00 , C12N15/64 , C12P19/34
CPC分类号： C07K16/1081 , A61K31/7088 , A61K39/12 , A61K39/21 , A61K48/00 , C07K16/1063 , C07K16/32 , C07K2317/14 , C07K2317/21 , C07K2317/55 , C07K2317/76 , C12N7/00 , C12N2740/16034 , C12N2740/16134 , C12N2770/24134 , C12N2770/36034
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
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公开(公告)号：EP2931318A2
公开(公告)日：2015-10-21
申请号：EP13863143.7
申请日：2013-12-13
IPC分类号： A61K48/00 , A61K39/395 , A61K39/00 , C07H21/04
CPC分类号： C07K16/1081 , A61K31/7088 , A61K39/12 , A61K39/21 , A61K48/00 , C07K16/1063 , C07K16/32 , C07K2317/14 , C07K2317/21 , C07K2317/55 , C07K2317/76 , C12N7/00 , C12N2740/16034 , C12N2740/16134 , C12N2770/24134 , C12N2770/36034 , Y02A50/383 , Y02A50/386
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
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公开(公告)号：EP3302535A1
公开(公告)日：2018-04-11
申请号：EP16728659.0
申请日：2016-06-03
申请人： Innovex Therapeutics, S.L. , Institució Catalana de Recerca i Estudis Avançats , Fundació Privada Institut De Salut Global Barcelona , Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol , Universitat de Lleida
发明人： DEL PORTILLO OBANDO, Hernando Antonio , BORRÁS SERRES, Francisco Enrique , FRAILE SAUCE, Lorenzo José , MONTANER TARBES, Sergio Roberto , MONTOYA GONZÁLEZ, Maria
CPC分类号： A61K39/12 , A61K9/127 , A61K38/1709 , A61K39/00 , A61K2039/55555 , A61K2039/64 , C12N2770/10034 , C12N2770/10051 , C12N2770/10071 , C12N2770/36034 , C12N2770/36051 , C12N2770/36071 , G06F19/703
摘要： The present invention provides exosomes isolated from an animal, wherein the animal (a) has overcome a disease caused by a pathogen, and (b) it is free from the pathogen that causes the diseases. The invention also provides process for obtaining these exosomes and the use thereof in therapy.
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公开(公告)号：EP3004348A4
公开(公告)日：2016-08-03
申请号：EP14807026
申请日：2014-06-02
申请人： VLP THERAPEUTICS LLC
发明人： UENO RYUJI , AKAHATA WATARU
IPC分类号： A61K39/015 , A61K39/12 , C07K14/18 , C07K14/445 , C07K19/00 , C12N7/00 , C12N15/09
CPC分类号： A61K39/015 , A61K38/162 , A61K39/12 , A61K39/193 , A61K2039/5258 , C07K14/005 , C07K14/445 , C07K2319/85 , C12N2770/36034 , C12N2770/36123 , C12N2770/36134 , A61K2300/00
摘要： The present invention provides a particle comprising a polypeptide and at least one malaria antigen, and a composition or vaccine comprising thereof, its use in medicine, particularly in the prevention or treatment of malaria infections.
摘要翻译： 本发明提供一种包含多肽和至少一种疟疾抗原的颗粒及其组合物或疫苗，其在医学中的用途，特别是在预防或治疗疟疾感染中的用途。
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公开(公告)号：EP3004348A1
公开(公告)日：2016-04-13
申请号：EP14807026.1
申请日：2014-06-02
发明人： UENO, Ryuji , AKAHATA, Wataru
IPC分类号： C12N15/09 , A61K39/015 , C07K14/18 , C07K14/445 , C07K19/00 , C12N7/00
CPC分类号： A61K39/015 , A61K38/162 , A61K39/12 , A61K39/193 , A61K2039/5258 , C07K14/005 , C07K14/445 , C07K2319/85 , C12N2770/36034 , C12N2770/36123 , C12N2770/36134 , Y02A50/412 , A61K2300/00
摘要： The present invention provides a particle comprising a polypeptide and at least one malaria antigen, and a composition or vaccine comprising thereof, its use in medicine, particularly in the prevention or treatment of malaria infections.
摘要翻译： 本发明提供了包含多肽和至少一种疟疾抗原的颗粒，以及包含其的组合物或疫苗，其在医学中的用途，特别是用于预防或治疗疟疾感染。
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