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公开(公告)号：EP2798080B1
公开(公告)日：2019-02-20
申请号：EP12806870.7
申请日：2012-12-20
发明人： SOKOLOVA, Irina , MORRISON, Larry , PESTOVA, Ekaterina , FRITCHER, Emily, Barr , ROBERTS, Lewis , GORES, Gregory , HALLING, Kevin , KIPP, Benjamin
IPC分类号： C12Q1/6827 , C12Q1/6886
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2.发明公开MATERIALS AND METHODS FOR DIAGNOSIS, PROGNOSIS, MONITORING OF RECURRENCE, AND ASSESSMENT OF THERAPEUTIC/PROPHYLACTIC TREATMENT OF PANCREATOBILIARY CANCER 审中-公开材料和诊断，预后，监测和评价癌症PANKREATOBILIÄREM用递推治疗性/预防性处理的方法
公开(公告)号：EP2798080A1
公开(公告)日：2014-11-05
申请号：EP12806870.7
申请日：2012-12-20
发明人： SOKOLOVA, Irina , MORRISON, Larry , PESTOVA, Ekaterina , FRITCHER, Emily, Barr , ROBERTS, Lewis , GORES, Gregory , HALLING, Kevin , KIPP, Benjamin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q2600/112 , C12Q2537/16
摘要： A method of detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract or inferring an increased risk thereof, comprising obtaining a sample of pancreatobiliary cells from a patient with a set of detectably labeled probes comprising a locus-specific probe for MCL1 (myeloid cell leukemia sequence 1), a locus-specific probe for EGFR (epidermal growth factor receptor), a locus-specific probe for MYC, and a locus-specific probe for P16 under hybridization conditions and determining the presence of chromosomal abnormalities; a set of probes comprising a locus-specific probe for MCL1, a locus-specific probe for EGFR, a locus-specific probe for MYC, and a locus-specific probe for P16; and a kit comprising the set of probes and instructions for detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract, or inferring an increased risk thereof, in a patient.
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公开(公告)号：EP3246417B1
公开(公告)日：2019-09-11
申请号：EP17175085.4
申请日：2006-02-17
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公开(公告)号：EP3246417A1
公开(公告)日：2017-11-22
申请号：EP17175085.4
申请日：2006-02-17
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Probe sets and methods of using probes and probe sets for selectively detecting high grade dysplasia and esophageal adenocarcinoma or low grade dysplasia from biologic samples are described. Methods of the invention include contacting a biological sample obtained from a subject with a set of chromosomal probes to selectively detect an esophageal carcinoma or precursor lesion in the sample, if any, under conditions for specifically hybridizing the probes to their nucleic targets present in the sample. The presence or absence of high grade dysplasia and esophageal adenocarcinoma or low grade dysplasia is thereafter specifically determined from the hybridization pattern detected for the set of chromosomal probes to the biological sample.
摘要翻译： 描述了使用探针和探针组选择性检测来自生物样品的高度发育不良和食管腺癌或低度不典型增生的探针组和方法。 本发明的方法包括使得自受试者的生物样品与一组染色体探针接触，以在特定杂交探针与样品中存在的核酸靶标的条件下选择性检测样品中的食管癌或前体病变（如果有的话） 。 之后根据针对生物学样品的该组染色体探针检测到的杂交模式特别确定是否存在高度发育不良和食管腺癌或低度发育异常。
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5.发明授权
公开(公告)号：EP2569624B1
公开(公告)日：2017-03-15
申请号：EP11780917.8
申请日：2011-05-10
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q1/6841 , C12Q2600/118 , C12Q2600/156
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