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    NUCLEIC ACID HYBRIDIZATION PROBES
    7.
    发明公开
    NUCLEIC ACID HYBRIDIZATION PROBES 审中-公开
    NUCLEINSÄUREHYBRIDISIERUNGSSONDEN

    公开(公告)号：EP2798092A2

    公开(公告)日：2014-11-05

    申请号：EP12863875.6

    申请日：2012-12-28

    申请人： Abbott Molecular Inc.

    发明人： RUSSELL, John, C. ,  PESTOVA, Ekaterina

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6876 ,  C12N15/1093 ,  C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/682 ,  C12Q1/6855 ,  C12Q2525/119 ,  C12Q2525/191 ,  C12Q2525/197 ,  C12Q2525/313 ,  C12Q2525/161 ,  C12Q2525/155

    摘要： Compositions of nucleic acid hybridization probes for detecting a nucleic acid target sequence and methods for their production are described. In one preferred embodiment, the nucleic acid hybridization probe includes a hybridization domain, an adaptor, a linker, and a signaling domain. The hybridization domain includes a nucleic acid sequence having complementarity to the nucleic acid target sequence. The adaptor is a nucleic acid sequence. The linker includes a moiety having at least one abasic site, such that the moiety blocks extension by an elongating polymerase on a nucleic acid template containing the moiety. The signaling domain comprises a nucleic acid having at least one label or a nucleic acid having at least one nucleic acid domain for binding at least one additional nucleic acid.

    MATERIALS AND METHODS FOR DIAGNOSIS, PROGNOSIS AND ASSESSMENT OF THERAPEUTIC/PROPHYLACTIC TREATMENT OF PROSTATE CANCER
    8.
    发明公开
    MATERIALS AND METHODS FOR DIAGNOSIS, PROGNOSIS AND ASSESSMENT OF THERAPEUTIC/PROPHYLACTIC TREATMENT OF PROSTATE CANCER 有权
    材料和诊断，预测与评价前列腺癌的治疗性/预防性治疗的方法

    公开(公告)号：EP2798082A1

    公开(公告)日：2014-11-05

    申请号：EP12815922.5

    申请日：2012-12-20

    申请人： Abbott Molecular Inc.

    发明人： ZHANG, Ying ,  MORRISON, Larry ,  PESTOVA, Ekaterina ,  SOKOLOVA, Irina

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/57434 ,  C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/48721 ,  G01N2333/47 ,  C12Q2537/16

    摘要： A method to detect prostate cancer comprising contacting a sample of prostate cells from the patient with a set of detectably labeled probes under hybridization conditions and determining the presence of chromosomal abnormalities in prostate tumor tissue, PIN (intra-epithelial neoplasia), histologically benign tissue and benign prostatic hyperplasia (BPH); a method to combine immunofluorescence and FISH (IF-FISH) to facilitate the assessment of chromosomal abnormalities; a set of probes; and a kit comprising the set of probes and instructions for diagnosing prostate cancer in a patient.

    摘要翻译： 一种检测前列腺癌包括从所述患者接触的前列腺细胞的样品与杂交条件下的一组可检测地标记的探针和确定性采矿染色体异常的在前列腺肿瘤组织中的存在，PIN（上皮内瘤形成），组织学良性组织和 良性前列腺增生（BPH）; 的方法结合免疫荧光和FISH（IF-FISH），以促进染色体异常的评估; 一组探针; 和试剂盒，包括一组探针和指令的用于诊断患者中的前列腺癌。