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公开(公告)号：EP3148591B1
公开(公告)日：2020-03-11
申请号：EP15727248.5
申请日：2015-05-27
发明人： BRADBURY, Michelle S. , YOO, Barney , WIESNER, Ulrich , MA, Kai
IPC分类号： A61K47/50 , A61K49/00 , A61K51/12 , A61K47/65 , A61K47/60 , A61K47/69 , A61K31/506 , A61K31/5377
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2.发明公开METHODS OF TREATMENT USING ULTRASMALL NANOPARTICLES TO INDUCE CELL DEATH OF NUTRIENT-DEPRIVED CANCER CELLS VIA FERROPTOSIS 审中-公开超声纳米颗粒诱导细胞死亡的方法治疗营养不良的癌细胞通过铁剂治疗
公开(公告)号：EP3302568A1
公开(公告)日：2018-04-11
申请号：EP16730103.5
申请日：2016-05-26
CPC分类号： A61K47/6929 , A61K38/22 , A61K47/60 , A61K47/6923
摘要： Described herein is a method of induced cell death via ferroptosis by nanoparticle ingestion. Moreover, the present disclosure describes the administration of high concentrations of ultrasmall nanoparticles at multiple times over the course of treatment in combination with a nutrient-depleted environment, thereby modulating cellular metabolic pathways to induce cell death by the mechanism ferroptosis. Ferroptosis involves iron, reactive oxygen species, and a synchronous mode of cell death execution.
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3.发明公开CYCLIC PEPTIDES WITH ENHANCED NERVE-BINDING SELECTIVITY, NANOPARTICLES BOUND WITH SAID CYCLIC PEPTIDES, AND USE OF SAME FOR REAL-TIME IN VIVO NERVE TISSUE IMAGING 审中-公开具有增强的神经结合选择性的环肽，结合了所述环肽的纳米颗粒以及用于实时进行体内神经组织成像的用途
公开(公告)号：EP3233134A1
公开(公告)日：2017-10-25
申请号：EP15820752.2
申请日：2015-12-15
发明人： BRADBURY, Michelle S. , YOO, Barney , WIESNER, Ulrich , CHEN, Peiming , MA, Kai , PATEL, Snehal G. , ZANONI, Daniella Karassawa
IPC分类号： A61K49/00
摘要： Described herein are cyclic peptides, nanoparticles bound with cyclic peptides, and methods for using said cyclic peptides and/or said nanoparticles bound with cyclic peptides for intraoperative nerve tissue imaging.
摘要翻译： 本文描述了环肽，与环肽结合的纳米粒子，以及使用所述环肽和/或与环肽结合的所述纳米粒子用于术中神经组织成像的方法。
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公开(公告)号：EP3634500A1
公开(公告)日：2020-04-15
申请号：EP18729255.2
申请日：2018-05-17
发明人： BRADBURY, Michelle S. , CHEN, Feng , WIESNER, Ulrich , MA, Kai
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公开(公告)号：EP3233134B1
公开(公告)日：2020-03-25
申请号：EP15820752.2
申请日：2015-12-15
发明人： BRADBURY, Michelle S. , YOO, Barney , WIESNER, Ulrich , CHEN, Peiming , MA, Kai , PATEL, Snehal G. , ZANONI, Daniella Karassawa
IPC分类号： A61K49/00
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6.发明公开
公开(公告)号：EP3389726A1
公开(公告)日：2018-10-24
申请号：EP16826234.3
申请日：2016-12-15
发明人： BRADBURY, Michelle S. , YOO, Barney , WIESNER, Ulrich , CHEN, Peiming , MA, Kai , PATEL, Snehal G. , ZANONI, Daniella Karassawa , DAYAN, Joseph , ABU-RUSTUM, Nadeem R.
CPC分类号： A61K49/0002 , A61K49/0032 , A61K49/0056 , A61K49/0058 , A61K49/0067 , A61K49/0093 , A61K51/1244
摘要： Described herein is a multiplex platform that uses ultrasmall nanoparticles (e.g., C dots and C' dots) to graphically differentiate specific nerves (e.g., sensory nerves vs. motor nerves) for nerve transplants and other surgeries. Also described herein is a multiplex platform that uses ultrasmall nanoparticles (e.g., C dots and C' dots) to graphically differentiate between different types of lymph nodes and/or lymphatic pathways, e.g., to safely and effectively perform vascularized lymph node transplantation in the treatment of lymphedema. Also described herein is a multiplex platform that uses ultrasmall nanoparticles (e.g., C dots and C' dots) to graphically differentiate parathyroid tissue.
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公开(公告)号：EP3280454A1
公开(公告)日：2018-02-14
申请号：EP16718099.1
申请日：2016-04-07
申请人： Memorial Sloan Kettering Cancer Center , Cornell University , The Curators of the University of Missouri
发明人： YOO, Barney , QUINN, Tom , BRADBURY, Michelle , WIESNER, Ulrich , LEWIS, Jason , MA, Kai , CHEN, Feng
CPC分类号： A61K47/6923 , A61K45/06 , A61K49/0058 , A61K49/1824 , A61K51/0478 , A61K51/10 , A61K51/1093 , A61K51/1251 , C07K16/40 , C07K2317/55 , C07K2317/569 , C07K2317/622
摘要： Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no greater than 20 nanometers (e.g., as measured by dynamic light scattering (DLS) in aqueous solution, e.g., saline solution). In certain embodiments, the conjugates are silica-based nanoparticles with single chain antibody fragments attached thereto.
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公开(公告)号：EP3693026A1
公开(公告)日：2020-08-12
申请号：EP20152240.6
申请日：2015-05-27
发明人： BRADBURY, Michelle S. , YOO, Barney , WIESNER, Ulrich , MA, Kai
摘要： Described herein are nanoparticle drug conjugates (NDCs), which, in certain embodiments, comprise a non-toxic, multi-modality, clinically proven silica-based nanoparticle platform with covalently attached drug molecules/moieties. The nanoparticle drug conjugates (NDCs) demonstrate imaging capability and targeting ligands which efficiently clear through the kidneys. Furthermore, the conjugates incorporate therapeutic agents for cancer detection, prevention, and/or treatment.
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公开(公告)号：EP3548096A1
公开(公告)日：2019-10-09
申请号：EP17825989.1
申请日：2017-11-29
申请人： Memorial Sloan Kettering Cancer Center , Cornell University , The Curators of the University of Missouri
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公开(公告)号：EP3148591A1
公开(公告)日：2017-04-05
申请号：EP15727248.5
申请日：2015-05-27
发明人： BRADBURY, Michelle S. , YOO, Barney , WIESNER, Ulrich , MA, Kai
摘要： Described herein are nanoparticle drug conjugates (NDCs), which, in certain embodiments, comprise a non-toxic, multi-modality, clinically proven silica-based nanoparticle platform with covalently attached drug molecules/moieties. The nanoparticle drug conjugates (NDCs) demonstrate imaging capability and targeting ligands which efficiently clear through the kidneys. Furthermore, the conjugates incorporate therapeutic agents for cancer detection, prevention, and/or treatment.
摘要翻译： 本文描述了纳米颗粒药物缀合物（NDC），其在某些实施方案中包含具有共价连接的药物分子/部分的无毒，多模态，临床证明的基于二氧化硅的纳米颗粒平台。 纳米颗粒药物缀合物（NDCs）展示成像能力和靶向配体，其有效透过肾脏。 此外，缀合物掺入用于癌症检测，预防和/或治疗的治疗剂。
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