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公开(公告)号：EP0804186A1
公开(公告)日：1997-11-05
申请号：EP95908099.0
申请日：1995-01-20
申请人： Merck & Co., Inc.
发明人： GARCIA, Maria, L. , GIACOBBE, Robert, A. , HENSENS, Otto, D. , LEE, Seok, H. , McMANUS, Owen, B. , ZINK, Deborah, L.
CPC分类号： C07D491/04 , C07D491/14 , C12P17/10 , C12P17/18
摘要： The present invention relates to compounds of formula (I) and the pharmaceutically acceptable salts thereof which are useful as potassium channel antagonists, particularly Maxi-K channel antagonists, and thus useful in treating Alzheimer's Disease and other cognitive disorders. This invention is also related to a method of making the compound of formula (I).
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其可用作钾通道拮抗剂，特别是Maxi-K通道拮抗剂，因此可用于治疗阿尔茨海默氏病和其他认知障碍。 本发明还涉及制备式（I）化合物的方法。
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2.发明公开POLYCYCLIC ANTIPARASITIC AGENTS, PROCESS AND STRAIN FOR THEIR PREPARATION AND THEIR USE 失效多环抗寄生虫药衍生物，工艺和生产掌握它们及其用途
公开(公告)号：EP0726902A1
公开(公告)日：1996-08-21
申请号：EP94932063.0
申请日：1994-10-27
申请人： Merck & Co., Inc.
发明人： DOMBROWSKI, Anne, W. , ENDRIS, Richard, G. , HELMS, Gregory, L. , HENSENS, Otto, D. , ONDEYKA, John, G. , OSTLIND, Dan, A. , POLISHOOK, Jon, D. , ZINK, Deborah, L.
CPC分类号： C07D491/16 , C12P17/18 , Y10S435/911
摘要： There are disclosed novel compounds having formulae (I - III) which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal agents.
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公开(公告)号：EP0804186B1
公开(公告)日：2002-04-17
申请号：EP95908099.5
申请日：1995-01-20
申请人： Merck & Co., Inc.
发明人： GARCIA, Maria, L. , GIACOBBE, Robert, A. , HENSENS, Otto, D. , LEE, Seok, H. , McMANUS, Owen, B. , ZINK, Deborah, L.
IPC分类号： A61K31/40 , C07D209/00 , C12P17/18
CPC分类号： C07D491/04 , C07D491/14 , C12P17/10 , C12P17/18
摘要： The present invention relates to compounds of formula (I) and the pharmaceutically acceptable salts thereof which are useful as potassium channel antagonists, particularly Maxi-K channel antagonists, and thus useful in treating Alzheimer's Disease and other cognitive disorders. This invention is also related to a method of making the compound of formula (I).
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4.发明授权POLYCYCLIC ANTIPARASITIC AGENTS, PROCESS AND STRAIN FOR THEIR PREPARATION AND THEIR USE 失效多环抗寄生虫药衍生物，工艺和生产掌握它们及其用途
公开(公告)号：EP0726902B1
公开(公告)日：2000-01-05
申请号：EP94932063.4
申请日：1994-10-27
申请人： Merck & Co., Inc.
发明人： DOMBROWSKI, Anne, W. , ENDRIS, Richard, G. , HELMS, Gregory, L. , HENSENS, Otto, D. , ONDEYKA, John, G. , OSTLIND, Dan, A. , POLISHOOK, Jon, D. , ZINK, Deborah, L.
IPC分类号： C07D491/16 , C07D491/22 , C12P17/18 , A01N43/90 , A61K31/40
CPC分类号： C07D491/16 , C12P17/18 , Y10S435/911
摘要： There are disclosed novel compounds having formulae (I - III) which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal agents.
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公开(公告)号：EP0664779A1
公开(公告)日：1995-08-02
申请号：EP93924330.0
申请日：1993-10-14
申请人： MERCK & CO. INC.
发明人： CABELLO, Angeles , HARRIS, Guy , GIACOBBE, Robert, A. , HELMS, Gregory, Lee , HENSENS, Otto, D. , MANDALA, Suzanne, Miller , JONES, E., Tracy, Turner , MARTIN, Isabel , ROZDILSKY, Walter
CPC分类号： C12P7/26 , C07C49/743 , C07C69/013 , C12P7/62
摘要： Compounds having formula (I), wherein R and R1 may be H or COCH¿3? provided that when R?1¿ is COCH¿3?, R is COCH3 are described.
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