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1.发明授权POLYCYCLIC ANTIPARASITIC AGENTS, PROCESS AND STRAIN FOR THEIR PREPARATION AND THEIR USE 失效多环抗寄生虫药衍生物，工艺和生产掌握它们及其用途
公开(公告)号：EP0726902B1
公开(公告)日：2000-01-05
申请号：EP94932063.4
申请日：1994-10-27
申请人： Merck & Co., Inc.
发明人： DOMBROWSKI, Anne, W. , ENDRIS, Richard, G. , HELMS, Gregory, L. , HENSENS, Otto, D. , ONDEYKA, John, G. , OSTLIND, Dan, A. , POLISHOOK, Jon, D. , ZINK, Deborah, L.
IPC分类号： C07D491/16 , C07D491/22 , C12P17/18 , A01N43/90 , A61K31/40
CPC分类号： C07D491/16 , C12P17/18 , Y10S435/911
摘要： There are disclosed novel compounds having formulae (I - III) which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal agents.
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公开(公告)号：EP1793812A2
公开(公告)日：2007-06-13
申请号：EP05857569.7
申请日：2005-09-16
申请人： Merck & Co., Inc.
发明人： BARRETT, John, F. , HERATH, Kithsiri, B. , JAYASURIYA, Hiranthi , MASUREKAR, Prakash, S. , ONDEYKA, John, G. , SINGH, Sheo, Bux , ZHANG, Chaowei
IPC分类号： A61K31/00 , A61K38/12 , A61K38/14 , C12P21/02 , C12P21/04 , C07K9/00 , C07K7/50 , C07K7/54 , C07K7/58
摘要： Fermentation of a nutrient medium with a Nocardia spp. yields a novel broad spectrum antibiotic compound of structural formula (I) or a pharmaceutically acceptable salt, ester, enantiomer, diasteriomer or mixture.
摘要翻译： 用诺卡氏菌发酵营养培养基。 产生结构式（I）的新型广谱抗生素化合物或其药学上可接受的盐，酯，对映体，非对映异构体或混合物。
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公开(公告)号：EP0938308B1
公开(公告)日：2005-07-13
申请号：EP97938625.7
申请日：1997-08-26
申请人： MERCK & CO., INC.
发明人： BYRNE, Kevin, M. , DAHL, Arlene, M. , DOMBROWSKI, Anne, W. , GREENE, Joyce, A. , ONDEYKA, John, G. , OSTLIND, Dan, A. , SINGH, Sheo, B. , VESEY, Diane, M.
IPC分类号： A61K31/40 , C07D487/00 , C07D491/044 , C07D491/06 , C07D491/153
CPC分类号： C07D209/80 , C07D209/70 , C07D491/04 , C07D491/14 , C12P17/10 , C12P17/18 , C12R1/645 , Y10S435/911
摘要： Novel compounds isolated from the fermentation of producing cultures of Nodulisporium sp. are antiparasitic and insecticidal agents.
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公开(公告)号：EP1239855A2
公开(公告)日：2002-09-18
申请号：EP00983963.0
申请日：2000-12-07
申请人： Merck & Co., Inc.
CPC分类号： A61K31/216
摘要： The instant invention provides a method for raising serum HDL cholesterol levels comprising administering a therapeutically effective amount of an LXR ligand to a patient in need of such treatment. It further provides a method for using an LXR ligand to stimulate expression of the ABC1 gene. LXR ligands can be used for preventing and treating atherosclerosis and related conditions.
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公开(公告)号：EP0938308A1
公开(公告)日：1999-09-01
申请号：EP97938625.0
申请日：1997-08-26
申请人： MERCK & CO., INC.
发明人： BYRNE, Kevin, M. , DAHL, Arlene, M. , DOMBROWSKI, Anne, W. , GREENE, Joyce, A. , ONDEYKA, John, G. , OSTLIND, Dan, A. , SINGH, Sheo, B. , VESEY, Diane, M.
CPC分类号： C07D209/80 , C07D209/70 , C07D491/04 , C07D491/14 , C12P17/10 , C12P17/18 , C12R1/645 , Y10S435/911
摘要： Novel compounds isolated from the fermentation of producing cultures of Nodulisporium sp. are antiparasitic and insecticidal agents.
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6.发明公开POLYCYCLIC ANTIPARASITIC AGENTS, PROCESS AND STRAIN FOR THEIR PREPARATION AND THEIR USE 失效多环抗寄生虫药衍生物，工艺和生产掌握它们及其用途
公开(公告)号：EP0726902A1
公开(公告)日：1996-08-21
申请号：EP94932063.0
申请日：1994-10-27
申请人： Merck & Co., Inc.
发明人： DOMBROWSKI, Anne, W. , ENDRIS, Richard, G. , HELMS, Gregory, L. , HENSENS, Otto, D. , ONDEYKA, John, G. , OSTLIND, Dan, A. , POLISHOOK, Jon, D. , ZINK, Deborah, L.
CPC分类号： C07D491/16 , C12P17/18 , Y10S435/911
摘要： There are disclosed novel compounds having formulae (I - III) which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal agents.
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