专利检索 ap:("Merck & Co., Inc.") AND inv:"POLISHOOK, Jon, D." 第 1 页

1.

发明授权
POLYCYCLIC ANTIPARASITIC AGENTS, PROCESS AND STRAIN FOR THEIR PREPARATION AND THEIR USE 失效
标题翻译：多环抗寄生虫药衍生物，工艺和生产掌握它们及其用途

公开(公告)号：EP0726902B1

公开(公告)日：2000-01-05

申请号：EP94932063.4

申请日：1994-10-27

申请人： Merck & Co., Inc.

发明人： DOMBROWSKI, Anne, W. , ENDRIS, Richard, G. , HELMS, Gregory, L. , HENSENS, Otto, D. , ONDEYKA, John, G. , OSTLIND, Dan, A. , POLISHOOK, Jon, D. , ZINK, Deborah, L.

IPC分类号： C07D491/16 , C07D491/22 , C12P17/18 , A01N43/90 , A61K31/40

CPC分类号： C07D491/16 , C12P17/18 , Y10S435/911

摘要： There are disclosed novel compounds having formulae (I - III) which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal agents.

2.

发明公开
POLYCYCLIC ANTIPARASITIC AGENTS, PROCESS AND STRAIN FOR THEIR PREPARATION AND THEIR USE 失效
标题翻译：多环抗寄生虫药衍生物，工艺和生产掌握它们及其用途

公开(公告)号：EP0726902A1

公开(公告)日：1996-08-21

申请号：EP94932063.0

申请日：1994-10-27

申请人： Merck & Co., Inc.

发明人： DOMBROWSKI, Anne, W. , ENDRIS, Richard, G. , HELMS, Gregory, L. , HENSENS, Otto, D. , ONDEYKA, John, G. , OSTLIND, Dan, A. , POLISHOOK, Jon, D. , ZINK, Deborah, L.

IPC分类号： A01N43 , A01P7 , A61K31 , A61P33 , C07D491 , C12P17

CPC分类号： C07D491/16 , C12P17/18 , Y10S435/911

摘要： There are disclosed novel compounds having formulae (I - III) which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal agents.

3.

发明公开
INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE 失效
标题翻译：法尼蛋白转移酶抑制剂

公开(公告)号：EP0842291A1

公开(公告)日：1998-05-20

申请号：EP96925425.0

申请日：1996-07-22

申请人： MERCK & CO., INC.

发明人： CASCALES, Carmen , LINGHAM, Russell, B. , PELAEZ, Fernando , POLISHOOK, Jon, D. , SILVERMAN, Keith, C. , SINGH, Sheo, B. , ZINK, Deborah, L.

IPC分类号： C12N15 , A61K31 , A61P35 , C07D493 , C12N1 , C12N9 , C12P17 , C12R1

CPC分类号： C07D493/04 , C12P17/181

摘要： The present invention is directed to non-peptide compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention also relates to the process for the preparation of a compound of this invention by cultivating a culture of Phoma sp. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

摘要翻译： 本发明涉及抑制法尼基蛋白转移酶（FPTase）和癌基因蛋白Ras的法尼基化的非肽化合物。本发明还涉及通过培养Phoma sp。的培养物来制备本发明化合物的方法。本发明还涉及含有本发明化合物的化学治疗组合物以及抑制法尼基蛋白转移酶和癌基因蛋白Ras的法尼基化的方法。