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1.发明公开6-and/or 7-substituted -1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzofuran-3-ols as inhibitors of leukotriene biosynthesis 失效6和/或7-取代基1,2,3,4,4a，9b-六氢-8-羟基 - 二苯并呋喃-3-烯烃抑制剂白细胞生成素。
公开(公告)号：EP0420571A2
公开(公告)日：1991-04-03
申请号：EP90310478.4
申请日：1990-09-25
申请人： MERCK & CO. INC.
IPC分类号： C07D307/91 , C07D307/77 , A61K31/34
CPC分类号： C07D307/77 , C07D307/91
摘要： Positions 7-and/or 6-substituted 1,2,3,4,4a,9b-Hexahydro-8-hydroxydibenzofuran-3-ols and analogs of that general structure are described.
These compounds are found to be potent inhibitors of 5-lipoxygenase, an enzyme crucial to the biosynthesis of leukotrienes and useful in the treatment of a variety of inflammatory conditions.摘要翻译： 描述了这种一般结构的7-和/或6-取代的1,2,3,4,4a，9b-六氢-8-羟基二苯并呋喃-3-醇和类似物。 发现这些化合物是5-脂氧合酶的有效抑制剂，这是对白细胞三烯的生物合成至关重要并且可用于治疗各种炎性病症的酶。
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2.发明授权Aryl-substituted thiophene 3-ols, derivatives and analogs, as lipoxygenase inhibitors 失效ARYL替代的THIOPHENE 3-OLS，衍生物和类似物，作为LIPOXYGENASE抑制剂
公开(公告)号：EP0318066B1
公开(公告)日：1992-07-29
申请号：EP88202030.8
申请日：1988-09-16
申请人： Merck & Co., Inc.
IPC分类号： C07D333/32 , C07D333/64 , C07D333/78 , C07D333/80 , C07D333/50 , C07D409/04 , A61K31/38 , A61K31/44 , C07D333/00 , C07D409/00 , C07D307/00
CPC分类号： C07D409/04 , C07D333/32 , C07D333/50 , C07D333/64 , C07D333/78 , C07D333/80
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3.发明公开6-and/or 7-substituted -1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzofuran-3-ols as inhibitors of leukotriene biosynthesis 失效6-OR /或7-取代的-1,2,3,4,4A，9B-HEXAHYDRO-8-羟基二苯并呋喃-3-OLS作为紫苏酮生物合成酶的抑制剂
公开(公告)号：EP0420571A3
公开(公告)日：1991-05-15
申请号：EP90310478.4
申请日：1990-09-25
申请人： MERCK & CO. INC.
IPC分类号： C07D307/91 , C07D307/77 , A61K31/34
CPC分类号： C07D307/77 , C07D307/91
摘要： Positions 7-and/or 6-substituted 1,2,3,4,4a,9b-Hexahydro-8-hydroxydibenzofuran-3-ols and analogs of that general structure are described. These compounds are found to be potent inhibitors of 5-lipoxygenase, an enzyme crucial to the biosynthesis of leukotrienes and useful in the treatment of a variety of inflammatory conditions.
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4.发明公开Aryl-substituted thiophene 3-ols, derivatives and analogs, as lipoxygenase inhibitors 失效芳基取代基噻吩-3-ole，促进和分解脂肪氧合酶抑制剂。
公开(公告)号：EP0318066A1
公开(公告)日：1989-05-31
申请号：EP88202030.8
申请日：1988-09-16
申请人： Merck & Co., Inc.
IPC分类号： C07D333/32 , C07D333/64 , C07D333/78 , C07D333/80 , C07D333/50 , C07D409/04 , A61K31/38 , A61K31/44 , C07D333/00 , C07D409/00 , C07D307/00
CPC分类号： C07D409/04 , C07D333/32 , C07D333/50 , C07D333/64 , C07D333/78 , C07D333/80
摘要： Aryl substituted thiophenes 3-ols, its dihydro derivatives, 1-oxide and 1,1-dioxide analogs, as well as aryl substituted furans, are 5-lipoxygenase inhibitors useful in the treatment of inflammation and other leukotriene-mediated diseases.
摘要翻译： 芳基取代的噻吩3-ols，其二氢衍生物，1-氧化物和1,1-二氧化物类似物以及芳基取代的呋喃是可用于治疗炎症和其它白三烯介导的疾病的5-脂氧合酶抑制剂。
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