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1.发明公开
公开(公告)号：EP0293133A3
公开(公告)日：1990-01-31
申请号：EP88304494.3
申请日：1988-05-18
申请人： Merck & Co., Inc.
发明人： Dechard, Collette S. , Koupal, Lawrence R. , Hirsch, Charles F. , Meyers, Samuel P. , Kempf, August J. , Sykes, Ruth S. , Zawodny, Peggy S. , Mochales Sagrario , Wilson, Kenneth E.
CPC分类号： C12R1/365 , A01N43/28 , C07D317/36 , C12P17/04 , C12R1/625
摘要： The invention relates to novel microorganisms and a process for the manufacture of the tri-yne carbonate of formula I. Such compound can be produced by isolating it from the fermentation broth of ATCC-53614, ATCC-53615 or ATCC-53616. The tri-yne carbonate has antifungal activity.
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2.发明公开Novel anthelmintic milbemycin analogs of novel microorganisms 失效Anthelmintische Milbemycin-Analoge aus neuen Mikroorganismen。
公开(公告)号：EP0511881A1
公开(公告)日：1992-11-04
申请号：EP92303999.4
申请日：1992-05-01
申请人： MERCK & CO. INC.
发明人： Goegelman, Robert T. , Sykes, Ruth S. , Munguira, Elvira , Helms, Gregory L. , Diez Matas, Maria Teresa , Turner Jones, E. Tracy , Kong, Yu Lin , Liesch, Jerrold M.
IPC分类号： C07H19/01 , C07D493/22 , C12P17/18 , A01N43/90 , A61K31/70
摘要： There is disclosed a series of macrolides of formulae I-IV isolated from the fermentation broth of microorganisms identified as MA-6825, MA-6864 and MA-6865. The structure of the novel compounds isolated from the microorganisms is presented based upon analytical studies. The compounds are highly potent antiparasitic, insecticidal, and anthelmintic agents and are related to the class of macrolides known as milbemycins. Compositions for such uses are also disclosed.
摘要翻译： 公开了从被鉴定为MA-6825，MA-6864和MA-6865的微生物发酵液中分离出的一系列式I-IV的大环内酯类。 基于分析研究提出了从微生物分离的新化合物的结构。 这些化合物是非常有效的抗寄生虫，杀虫剂和驱肠虫剂，并且与称为米尔倍霉素的大环内酯类有关。 还公开了用于此类用途的组合物。
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公开(公告)号：EP0293131A3
公开(公告)日：1990-01-31
申请号：EP88304489.3
申请日：1988-05-18
申请人： Merck & Co., Inc.
发明人： Hensens, Otto D. , Kempf, August J. , Schwartz, Robert E. , Sykes, Ruth S. , Wichmann, Carol F. , Zimmerman, Sheldon B. , Zink, Deborah L. , Wilson, Kenneth E.
IPC分类号： C07D317/36 , A01N43/28
CPC分类号： C07D317/36 , A01N43/28
摘要： The invention relates to a novel tri-yne carbonate of formula I. Such compound can be produced by isolating it from the fermentation broth of ATCC-53614, ATCC-53615 or ATCC-53616. The tri-yne carbonate has antifungal activity.
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4.发明公开Microorganisms and processes for the manufacture of antifungal tri-yne carbonates 失效Mikroorganismen und Prozesse zur Herstellung von fungiziden Tri-yne-Carbonaten。
公开(公告)号：EP0293133A2
公开(公告)日：1988-11-30
申请号：EP88304494.3
申请日：1988-05-18
申请人： Merck & Co., Inc.
发明人： Dechard, Collette S. , Koupal, Lawrence R. , Hirsch, Charles F. , Meyers, Samuel P. , Kempf, August J. , Sykes, Ruth S. , Zawodny, Peggy S. , Mochales Sagrario , Wilson, Kenneth E.
CPC分类号： C12R1/365 , A01N43/28 , C07D317/36 , C12P17/04 , C12R1/625
摘要： The invention relates to novel microorganisms and a process for the manufacture of the tri-yne carbonate of formula I. Such compound can be produced by isolating it from the fermentation broth of ATCC-53614, ATCC-53615 or ATCC-53616. The tri-yne carbonate has antifungal activity.
摘要翻译： 本发明涉及新颖的微生物和制备式I的三碳酸酯的方法。该化合物可以通过从ATCC-53614，ATCC-53615或ATCC-53616的发酵液中分离来制备。 三烯碳酸酯具有抗真菌活性。
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公开(公告)号：EP0293131A2
公开(公告)日：1988-11-30
申请号：EP88304489.3
申请日：1988-05-18
申请人： Merck & Co., Inc.
发明人： Hensens, Otto D. , Kempf, August J. , Schwartz, Robert E. , Sykes, Ruth S. , Wichmann, Carol F. , Zimmerman, Sheldon B. , Zink, Deborah L. , Wilson, Kenneth E.
IPC分类号： C07D317/36 , A01N43/28
CPC分类号： C07D317/36 , A01N43/28
摘要： The invention relates to a novel tri-yne carbonate of formula I. Such compound can be produced by isolating it from the fermentation broth of ATCC-53614, ATCC-53615 or ATCC-53616. The tri-yne carbonate has antifungal activity.
摘要翻译： 本发明涉及式I的新型三烯碳酸酯。该化合物可以通过从ATCC-53614，ATCC-53615或ATCC-53616的发酵液中分离来制备。 三烯碳酸酯具有抗真菌活性。
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