公开(公告)号：EP1436397A2

公开(公告)日：2004-07-14

申请号：EP02773740.2

申请日：2002-10-10

申请人： Merck & Co., Inc. ,  Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A.

发明人： EMINI, Emilio, A. ,  KASLOW, David, C. ,  BETT, Andrew, J. ,  SHIVER, John, W. ,  NICOSIA, Alfredo ,  LAHM, Armin ,  LUZZAGO, Alessandra ,  CORTESE, Riccardo ,  COLLOCA, Stefano

IPC分类号： C12N15/40 ,  C12N15/51 ,  C12N15/85 ,  C12N15/86 ,  C12N15/861 ,  A61K48/00

CPC分类号： C07K14/005 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/57 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2770/24222 ,  C12N2770/24234 ,  C12N2800/108 ,  C12N2810/6018 ,  C12N2830/003 ,  C12N2840/20 ,  C12N2840/203

摘要： The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV.

公开(公告)号：EP0946189A1

公开(公告)日：1999-10-06

申请号：EP97946043.0

申请日：1997-11-18

申请人： Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A.

发明人： CILIBERTO, Gennaro ,  COSTA, Patrizia ,  PAONESSA, Giacomo ,  LAZZARO, Domenico ,  GLOAGUEN, Isabelle ,  DI MARCO, Annalise ,  DE MARTIS, Anna ,  LAUFER, Ralph ,  CORTESE, Riccardo

IPC分类号： A61K45 ,  A61K38 ,  A61K48 ,  A61P3 ,  A61P43

CPC分类号： A61K38/185 ,  A61K38/2264 ,  A61K48/00 ,  A61K2300/00

摘要： The present invention refers to the use of hCNTF (human ciliary neurotrophic factor), mutants thereof or other molecules that activate the CNTF receptor, for the preparation of drugs for the treatment of obesity and associated diseases, for example hyperglycemia. Figure 1 shows the anti-obesity effect of hCNTF and leptin on body weight (left panels) and on food intake (right panels) in genetically obese mice and in mice with diet-induced obesity (DIO).

公开(公告)号：EP0946189B1

公开(公告)日：2002-11-20

申请号：EP97946043.3

申请日：1997-11-18

申请人： Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A.

发明人： CILIBERTO, Gennaro ,  COSTA, Patrizia ,  PAONESSA, Giacomo ,  LAZZARO, Domenico ,  GLOAGUEN, Isabelle ,  DI MARCO, Annalise ,  DE MARTIS, Anna ,  LAUFER, Ralph ,  CORTESE, Riccardo

IPC分类号： A61K38/18 ,  A61K48/00 ,  A61K38/22 ,  A61P3/04 ,  A61P3/10

CPC分类号： A61K38/185 ,  A61K38/2264 ,  A61K48/00 ,  A61K2300/00

摘要： The present invention refers to the use of hCNTF (human ciliary neurotrophic factor), mutants thereof or other molecules that activate the CNTF receptor, for the preparation of drugs for the treatment of obesity and associated diseases, for example hyperglycemia. Figure 1 shows the anti-obesity effect of hCNTF and leptin on body weight (left panels) and on food intake (right panels) in genetically obese mice and in mice with diet-induced obesity (DIO).