公开(公告)号：EP3258929A1

公开(公告)日：2017-12-27

申请号：EP16752841.3

申请日：2016-02-12

Applicant: Merck Sharp & Dohme Corp.

Inventor： MENG, Dongfang ,  LI, Hong ,  YANG, Meng ,  RUIZ, Manuel de Lera ,  DEWNANI, Sunita, V. ,  JIAN, Tianying ,  PARKER, Dann, L., Jr. ,  ZHANG, Ting ,  CAMPEAU, Louis-Charles ,  HARPER, Bart ,  WOOD, Harold, B. ,  XU, Jiayi ,  BERGER, Richard ,  WU, Jane Yang ,  ORR, Robert, K. ,  WALSH, Shawn, P.

IPC: A61K31/33 ,  A61K31/41 ,  A61K31/395 ,  A61K31/4164 ,  A61K31/4184

CPC classification number: C07D471/04 ,  C07D403/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/14 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

公开(公告)号：EP2931734A1

公开(公告)日：2015-10-21

申请号：EP13864999.1

申请日：2013-12-12

Applicant: Merck Sharp & Dohme Corp.

Inventor： LIN, Songnian ,  CAMPBELL, Brian ,  DEWNANI, Sunita, V. ,  KATS-KAGAN, Roman ,  XU, Jiayi ,  XU, Libo ,  ZHANG, Rui

IPC: C07F9/32

CPC classification number: C07F9/6539 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/675 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04 ,  C07F7/0812 ,  C07F9/587 ,  C07F9/65583

Abstract: Novel pyridine-2-carboxamide derivatives of formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are effective as glucokinase activating agents. Pharmaceutical compositions and methods of treatment are also included.

公开(公告)号：EP2931734B1

公开(公告)日：2020-12-02

申请号：EP13864999.1

申请日：2013-12-12

Applicant: Merck Sharp & Dohme Corp.

Inventor： LIN, Songnian ,  CAMPBELL, Brian ,  DEWNANI, Sunita, V. ,  KATS-KAGAN, Roman ,  XU, Jiayi ,  XU, Libo ,  ZHANG, Rui

IPC: C07F9/32 ,  C07D401/14 ,  A61K31/444 ,  A61P3/10