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公开(公告)号：EP3038466A1
公开(公告)日：2016-07-06
申请号：EP14840648.1
申请日：2014-08-25
发明人： ALI, Amjad , GALLO, Gioconda, V. , HENDERSON, Timothy, J. , KUANG, Rongze , LIM, Yeon-Hee , LO, Michael Man-Chu , METZGER, Edward , RUIZ, Manuel de Lera , STAMFORD, Andrew , TEMPEST, Paul , WHITEHEAD, Brent , WU, Heping
CPC分类号： C07D519/00 , C07D491/147
摘要： The present invention is directed to 2,2-difluorodioxolo compounds that are antagonists of A
2A receptor. The present invention is also directed to uses of the 2,2- difluorodioxolo compounds described herein in the potential treatment or prevention of 5 neurological disorders and diseases in which A
2A receptor are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds and to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which A
2A receptors are involved.摘要翻译： 本发明涉及作为A 2A受体的拮抗剂的2,2-二氟间二氧杂环戊烯化合物。 本发明还涉及本文所述的2,2-二氟二氧代环戊烯化合物在潜在治疗或预防其中涉及A 2A受体的5种神经障碍和疾病中的用途。 本发明还涉及包含这些化合物的药物组合物，并涉及这些药物组合物在预防或治疗涉及A 2A受体的疾病中的用途。
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公开(公告)号：EP3038466B1
公开(公告)日：2018-05-23
申请号：EP14840648.1
申请日：2014-08-25
发明人： ALI, Amjad , GALLO, Gioconda, V. , HENDERSON, Timothy, J. , KUANG, Rongze , LIM, Yeon-Hee , LO, Michael Man-Chu , METZGER, Edward , RUIZ, Manuel de Lera , STAMFORD, Andrew , TEMPEST, Paul , WHITEHEAD, Brent , WU, Heping
IPC分类号： C07D519/00 , C07D491/147 , A61K31/519 , A61P25/00 , A61P25/16 , A61P25/28
CPC分类号： C07D519/00 , C07D491/147
摘要： The present invention is directed to 2,2-difluorodioxolo compounds that are antagonists of A2A receptor. The present invention is also directed to uses of the 2,2-difluorodioxolo compounds described herein in the potential treatment or prevention of neurological disorders and diseases in which A2A receptor are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds and to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which A2A receptors are involved.
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公开(公告)号：EP3258929A1
公开(公告)日：2017-12-27
申请号：EP16752841.3
申请日：2016-02-12
发明人： MENG, Dongfang , LI, Hong , YANG, Meng , RUIZ, Manuel de Lera , DEWNANI, Sunita, V. , JIAN, Tianying , PARKER, Dann, L., Jr. , ZHANG, Ting , CAMPEAU, Louis-Charles , HARPER, Bart , WOOD, Harold, B. , XU, Jiayi , BERGER, Richard , WU, Jane Yang , ORR, Robert, K. , WALSH, Shawn, P.
IPC分类号： A61K31/33 , A61K31/41 , A61K31/395 , A61K31/4164 , A61K31/4184
CPC分类号： C07D471/04 , C07D403/12 , C07D413/14 , C07D417/14 , C07D471/14 , C07D498/04 , C07D513/04
摘要： The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.
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公开(公告)号：EP3253390A1
公开(公告)日：2017-12-13
申请号：EP16747041.8
申请日：2016-02-01
发明人： ALI, Amjad , ZHOU, Gang , KUANG, Rongze , LIM, Yeon-Hee , LO, Michael Man-Chu , TING, Pauline C. , BIJU, Purakkattle , RUIZ, Manuel de Lera , DEGRADO, Sylvia J. , TUNG, Alexander L. , HENDERSON, Timothy J. , HONG, Liwu , KIM, Jae-Hun , KIM, David Won-Shik , LEE, Joe F. , WU, Jie , WU, Heping , XIAO, Yushi , YU, Tao , ZHU, Xiaohong , MCCORMICK, Kevin D. , TAGAT, Jayaram R. , XIAO, Dong , KHAN, Tanweer , CAO, Jianhua , BERLIN, Michael , ZHANG, Yonglian
IPC分类号： A61K31/517 , C07D239/84 , C07D403/12
CPC分类号： C07D239/84 , A61K31/517 , A61P25/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to compounds of generic formula I: or pharmaceutically acceptable salts thereof that are believed to be useful as an A2A-receptor antagonist.
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