公开(公告)号：EP3976027A1

公开(公告)日：2022-04-06

申请号：EP20812542.7

申请日：2020-05-26

Applicant: Merck Sharp & Dohme Corp.

Inventor： HICKS, Jacqueline, D. ,  DEBENHAM, John, S. ,  ALI, Amjad ,  WEI, Lan ,  JIAN, Tianying ,  YANG, Dexi ,  OGAWA, Anthony, K. ,  FU, Wenlang ,  LOMBARDO, Matthew ,  KUANG, Rongze ,  YANG, Meng ,  SO, Sung-Sau ,  ELLSWORTH, Kenneth ,  NIZNER, Peter ,  TATOSIAN, Daniel, A. ,  WILKENING, Robert, R. ,  WANG, Jun

IPC: A61K31/4162 ,  A61P7/02

公开(公告)号：EP3389654A1

公开(公告)日：2018-10-24

申请号：EP16876635.0

申请日：2016-12-15

Applicant: Merck Sharp & Dohme Corp.

Inventor： GRESHOCK, Thomas, J. ,  MULHEARN, James ,  GUO, Liangqin ,  ZHANG, Ting ,  WANG, Deping ,  KIM, Ronald, M. ,  LAYTON, Mark, E. ,  KELLY, Michael, J., III ,  ANAND, Rajan ,  JIAN, Tianying ,  NANTERMET, Philippe ,  ROECKER, Anthony, J. ,  WON, Walter ,  ZHOU, Gang

IPC: A61K31/425 ,  A61P43/00 ,  C07C311/15

CPC classification number: C07D417/12 ,  A61K45/06 ,  A61P11/14 ,  A61P17/04 ,  A61P25/02 ,  A61P25/04 ,  C07D277/52 ,  C07D285/135

Abstract: Disclosed are compounds of Formula A, or a salt thereof, where Q, X, R1 and R2 are as defined herein, which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain (acute, post-operative, neuropathic), or cough or itch disorders using the same.

公开(公告)号：EP1940842B1

公开(公告)日：2012-05-30

申请号：EP06815303.0

申请日：2006-09-25

Applicant: Merck Sharp & Dohme Corp.

Inventor： JIAN, Tianying ,  LIU, Jian ,  NARGUND, Ravi, P.

IPC: C07D491/20 ,  A61K31/4355 ,  A61P3/00 ,  A61P15/00

CPC classification number: C07D471/10

Abstract: Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

公开(公告)号：EP3229801A1

公开(公告)日：2017-10-18

申请号：EP15866965.5

申请日：2015-12-07

Applicant: Merck Sharp & Dohme Corp. ,  Mochida Pharmaceutical Co., Ltd.

Inventor： ZHANG, Ting ,  CHEN, Yi-Heng ,  GUO, Liangqin ,  HRUZA, Alan ,  JIAN, Tianying ,  LI, Bing ,  MENG, Dongfang ,  PARKER, Dann, L., Jr. ,  SHERER, Edward, C. ,  WOOD, Harold, B. ,  SAKURADA, Isao

IPC: A61K31/4184 ,  C07D235/04

Abstract: The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

Abstract translation: 本发明提供式I化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防不稳定心绞痛，难治性心绞痛，心肌梗塞，短暂性脑缺血发作，心房纤颤，血栓性中风，栓塞 中风，深静脉血栓形成，弥散性血管内凝血，纤维蛋白的眼部积聚以及再通血管的再闭塞或再狭窄。 这些化合物是选择性因子IXa抑制剂。

公开(公告)号：EP2178537A1

公开(公告)日：2010-04-28

申请号：EP08780184.1

申请日：2008-07-15

Applicant: Merck Sharp & Dohme Corp.

Inventor： DOBBELAAR, Peter, H. ,  DU, Wu ,  GUO, Liangqin ,  HAGMANN, William, K. ,  HE, Shuwen ,  JIAN, Tianying ,  LIU, Jian ,  NARGUND, Ravi, P. ,  PASTERNAK, Alexander ,  SHAH, Shrenik, K. ,  TRUONG, Quang, T. ,  YE, Zhixiong ,  DELLUREFICIO, James ,  BAKSHI, Raman

IPC: A61K31/535

CPC classification number: C07D471/04

Abstract: Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.

公开(公告)号：EP3229801B1

公开(公告)日：2020-04-01

申请号：EP15866965.5

申请日：2015-12-07

Applicant: Merck Sharp & Dohme Corp. ,  Mochida Pharmaceutical Co., Ltd.

Inventor： ZHANG, Ting ,  CHEN, Yi-Heng ,  GUO, Liangqin ,  HRUZA, Alan ,  JIAN, Tianying ,  LI, Bing ,  MENG, Dongfang ,  PARKER, Dann, L., Jr. ,  SHERER, Edward, C. ,  WOOD, Harold, B. ,  SAKURADA, Isao

IPC: A61K31/4184 ,  C07D235/04

公开(公告)号：EP3258929A1

公开(公告)日：2017-12-27

申请号：EP16752841.3

申请日：2016-02-12

Applicant: Merck Sharp & Dohme Corp.

Inventor： MENG, Dongfang ,  LI, Hong ,  YANG, Meng ,  RUIZ, Manuel de Lera ,  DEWNANI, Sunita, V. ,  JIAN, Tianying ,  PARKER, Dann, L., Jr. ,  ZHANG, Ting ,  CAMPEAU, Louis-Charles ,  HARPER, Bart ,  WOOD, Harold, B. ,  XU, Jiayi ,  BERGER, Richard ,  WU, Jane Yang ,  ORR, Robert, K. ,  WALSH, Shawn, P.

IPC: A61K31/33 ,  A61K31/41 ,  A61K31/395 ,  A61K31/4164 ,  A61K31/4184

CPC classification number: C07D471/04 ,  C07D403/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/14 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.