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公开(公告)号：EP2948458A1
公开(公告)日：2015-12-02
申请号：EP14743619.0
申请日：2014-01-22
发明人： WU, Hao , KIM, Ronald M. , LIU, Jian , GAO, Xiaolei , BOGA, Sobhana Babu , GUIADEEN, Deodialsingh , KOZLOWSKI, Joseph , YU, Wensheng , ANAND, Rajan , YU, Younong , SELYUTIN, Oleg B. , GAO, Ying-Duo , LIU, Shilan , YANG, Chundao , WANG, Hongjian
IPC分类号： C07D487/04 , C07D253/06 , C07D519/00 , A61K31/52 , A61K31/519
CPC分类号： C07D491/048 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5365 , A61K31/5383 , A61K45/06 , C07D455/02 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00 , Y02A50/411 , Y02A50/463
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
摘要翻译： 本发明提供根据式I的布鲁顿酪氨酸激酶（Btk）抑制剂化合物或其药学上可接受的盐或包含这些化合物的药物组合物以及它们在治疗中的用途。 具体而言，本发明涉及Btk抑制剂化合物在治疗Btk介导的病症中的用途。
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公开(公告)号：EP3280419B1
公开(公告)日：2019-10-30
申请号：EP16777095.7
申请日：2016-04-04
发明人： SIU, Tony , ALTMAN, Michael D. , ANDRESEN, Brian M. , LIU, Jian , KOZLOWSKI, Joseph , BOGA, Sobhana Babu , YU, Younong , ANAND, Rajan , CAI, Jiaqiang , WANG, Dahai , LIU, Shilan
IPC分类号： A61K31/55 , A61K31/501 , A61K31/506 , C07D401/14 , C07D405/14 , C07D413/14 , A61P19/02
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公开(公告)号：EP2734529B1
公开(公告)日：2018-09-05
申请号：EP12814549.7
申请日：2012-07-19
发明人： DE MAN, Adrianus P.A. , STERRENBURG, Jan-Gerard , RAAIJMAKERS, Hans C.A. , KAPTEIN, Allard , OUBRIE, Arthur , REWINKEL, Johannes B.M. , JANS, Christiaan G.J.M. , WIJKMANS, Jacobus C.H.M , BARF, Tjeerd A. , COOPER, Alan B. , KIM, Ronald M. , BOGA, Sobhana Babu , ZHU, Hugh Y. , GAO, Xiaolei , YAO, Xin , ANAND, Rajan , WU, Hao , LIU, Shilan , YANG, Chundao , ALHASSAN, Abdul-Basit , WANG, James , YU, Younong , LIU, Jian , VACCARO, Henry M.
IPC分类号： C07D487/04 , C07D519/00 , A61K31/4985 , A61P19/08 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D513/04 , C07D519/00
摘要： The present invention provides 6-5 membered fused pyridine ring compounds according to Formula I or pharmaceutically acceptable salts thereof. or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
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公开(公告)号：EP3280418A1
公开(公告)日：2018-02-14
申请号：EP16777094.0
申请日：2016-04-04
发明人： LIU, Jian , KOZLOWSKI, Joseph , KIM, Ronald , GAO, Xiaolei , BOGA, Sobhana Babu , YU, Younong , WU, Hao , LIU, Shilan , YANG, Chundao
IPC分类号： A61K31/5377 , A61K31/55 , C07D487/04 , A61K31/541
CPC分类号： C07D519/00 , A61P19/02
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, wherein CH, R1, R1a, R1b, R2, R3, and the subscripts m1, m2, p, q, and t are as set forth herein. The present invention also provides pharmaceutical compositions comprising these compounds and their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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公开(公告)号：EP2948431B1
公开(公告)日：2019-03-13
申请号：EP14743190.2
申请日：2014-01-17
发明人： WU, Hao , KIM, Ronald, M. , LIU, Jian , LIU, Shilan , YANG, Chundao , ZHENG, Shuling
IPC分类号： C07D213/75 , A61K31/519 , A61K31/4985 , A61P35/00
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公开(公告)号：EP2734529A1
公开(公告)日：2014-05-28
申请号：EP12814549.7
申请日：2012-07-19
发明人： DE MAN, Adrianus P.A. , STERRENBURG, Jan-Gerard , RAAIJMAKERS, Hans C.A. , KAPTEIN, Allard , OUBRIE, Arthur , REWINKEL, Johannes B.M. , JANS, Christiaan G.J.M. , WIJKMANS, Jacobus C.H.M , BARF, Tjeerd A. , COOPER, Alan B. , KIM, Ronald M. , BOGA, Sobhana Babu , ZHU, Hugh Y. , GAO, Xiaolei , YAO, Xin , ANAND, Rajan , WU, Hao , LIU, Shilan , YANG, Chundao , ALHASSAN, Abdul-Basit , WANG, James , YU, Younong , LIU, Jian , VACCARO, Henry M.
IPC分类号： C07D497/02 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/52 , A61K31/53 , A61P3/10 , A61P7/02 , A61P9/00 , A61P19/02 , A61P25/00
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D513/04 , C07D519/00
摘要： The present invention provides 6-5 membered fused pyridine ring compounds according to Formula I or pharmaceutically acceptable salts thereof. or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
摘要翻译： 本发明提供了根据式I的6-5元稠合吡啶环化合物或其药学上可接受的盐。 或其药学上可接受的盐或包含这些化合物的药物组合物及其在治疗中的用途。 特别地，本发明涉及6-5元稠合吡啶环化合物在治疗布鲁特酪氨酸激酶（Btk）介导的病症中的用途。
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公开(公告)号：EP2542545A1
公开(公告)日：2013-01-09
申请号：EP11750145.2
申请日：2011-03-02
发明人： MCCOMAS, Casey, Cameron , LIVERTON, Nigel, J. , SOLL, Richard , LI, Peng , PENG, Xuanjia , WU, Hao , NARJES, Frank , HABERMANN, Joerg , KOCH, Uwe , LIU, Shilan
IPC分类号： C07D307/84 , C07D405/04 , C07D405/10 , A61K31/343 , A61P31/14
CPC分类号： C07D307/84 , A61K31/343 , A61K45/06 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/10 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D473/00 , C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61K2300/00
摘要： Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 所公开的是用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的式（I）化合物，这些化合物的合成，以及这些化合物用于抑制HCV NS5B聚合酶活性的用途，用于治疗或预防HCV感染和用于抑制 在基于细胞的系统中HCV病毒复制和/或病毒产生。
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公开(公告)号：EP3280418B1
公开(公告)日：2020-05-06
申请号：EP16777094.0
申请日：2016-04-04
发明人： LIU, Jian , KOZLOWSKI, Joseph , KIM, Ronald , GAO, Xiaolei , BOGA, Sobhana Babu , YU, Younong , WU, Hao , LIU, Shilan , YANG, Chundao
IPC分类号： A61K31/5377 , A61K31/55 , C07D487/04 , A61K31/541
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公开(公告)号：EP2948458B1
公开(公告)日：2019-05-01
申请号：EP14743619.0
申请日：2014-01-22
发明人： WU, Hao , KIM, Ronald M. , LIU, Jian , GAO, Xiaolei , BOGA, Sobhana Babu , GUIADEEN, Deodialsingh , KOZLOWSKI, Joseph , YU, Wensheng , ANAND, Rajan , YU, Younong , SELYUTIN, Oleg B. , GAO, Ying-Duo , LIU, Shilan , YANG, Chundao , WANG, Hongjian
IPC分类号： C07D519/00 , C07D487/04 , C07D498/04 , A61K31/4985 , A61K31/519 , A61K31/5365 , A61K31/5383 , A61P19/02 , A61P29/00 , A61P37/00
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公开(公告)号：EP3302480A1
公开(公告)日：2018-04-11
申请号：EP16804195.2
申请日：2016-05-31
发明人： DE MAN, Adrianus Petrus Antonius , KIM, Ronald , LIU, Jian , KOZLOWSHI, Joseph A. , BOGA, Sobhana Babu , FISCHMANN, Thierry , GUIADEEN, Deodiasingh , POLS-DE ROOIJ, Ilse Hendrica Maria , LIU, Shilan , WU, Hao
IPC分类号： A61K31/50 , A61K31/505 , C07D487/04
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/5377 , A61P19/02
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
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