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公开(公告)号：EP2513098A1
公开(公告)日：2012-10-24
申请号：EP10801736.9
申请日：2010-12-15
发明人： ALTMANN, Michael D. , ANDRESEN, Brian M. , ARRINGTON, Kenneth L. , CHILDERS, Kaleen Konrad , DI FRANCESCO, Maria Emilia , DONOFRIO, Anthony , ELLIS, John Michael , FISCHER, Christian , GUERIN, David Joseph , HAIDLE, Andrew M. , KATTAR, Solomon , KNOWLES, Sandra Lee , LI, Chaomin , LIM, Jongwon , MACHACEK, Michelle , NORTHRUP, Alan B. , O'BOYLE, Brendan M. , OTTE, Ryan D. , PETROCCHI, Alessia , REUTERSHAN, Michael H. , ROMEO, Eric , SIU, Tony , TAOKA, Brandon M. , TROTTER, B. Wesley , ZHOU, Hua , BURCH, Jason , COTE, Bernard , DUPONT-GAUDET, Kristina , FOURNIER, Jean-Francois , GAUTHIER, Jacques Yves , GUAY, Daniel , ROBICHAUD, Joel S. , GRIMM, Jonathan , MADDESS, Matthew L. , SCHELL, Adam J. , SPENCER, Kerrie B. , WOO, Hyun Chong , BHAT, Sathesh
IPC分类号： C07D417/12 , C07D417/14 , A61K31/497 , A61P11/00 , A61P11/06 , A61P29/00 , A61P35/00
CPC分类号： C07D417/12 , C07D417/14 , C07D451/06 , C07D471/04 , C07D471/08 , C07D487/04 , C07D491/08 , C07D495/04 , C07F9/65583
摘要： The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
摘要翻译： 本发明提供了式（I）的新型嘧啶胺，它们是脾酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD和类风湿性关节炎。
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公开(公告)号：EP3200790A1
公开(公告)日：2017-08-09
申请号：EP15847644.0
申请日：2015-09-25
发明人： ALTMAN, Michael D. , ANDRESEN, Brian M. , BRUBAKER, Jason D. , DONOFRIO, Anthony , FISCHMANN, Thierry , GIBEAU, Craig R. , LESBURG, Charles A. , LIM, Jongwon , MACLEAN, John K. F. , MANSOOR, Umar F. , NORTHRUP, Alan B. , SANDERS, John M. , SMITH, Graham F. , TORRES, Luis
IPC分类号： A61K31/444 , A61K31/506 , A61K45/06
CPC分类号： A61K31/517 , A61K45/06 , A61P29/00 , A61P35/00 , C07D239/94 , C07D405/04 , A61K2300/00
摘要： The present invention relates to inhibitors of IRAK4 of Formula I and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：EP2934525B1
公开(公告)日：2019-05-08
申请号：EP13864370.5
申请日：2013-12-19
发明人： ALTMAN, Michael D. , ANDRESEN, Brian M. , ARRINGTON, Kenneth L. , CHILDERS, Kaleen Konrad , DI FRANCESCO, Maria Emilia , ELLIS, John Michael , HAIDLE, Andrew M. , LIU, Yuan , NORTHRUP, Alan , O'BOYLE, Brendan , OTTE, Ryan D. , REUTERSHAN, Michael H. , VITHARANA, Dilrukshi , WOO, Hyun Chong
IPC分类号： A61K31/44 , A61P35/00 , C07D417/14
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公开(公告)号：EP3280419A1
公开(公告)日：2018-02-14
申请号：EP16777095.7
申请日：2016-04-04
发明人： SIU, Tony , ALTMAN, Michael D. , ANDRESEN, Brian M. , LIU, Jian , KOZLOWSKI, Joseph , BOGA, Sobhana Babu , YU, Younong , ANAND, Rajan , CAI, Jiaqiang , WANG, Dahai , LIU, Shilan
IPC分类号： A61K31/55 , A61K31/501 , A61K31/506
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R7, R8 and R9 are as herein described. The present invention also provides pharmaceutical compositions comprising these compounds and methods for their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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公开(公告)号：EP3200787B1
公开(公告)日：2019-09-04
申请号：EP15846218.4
申请日：2015-09-25
发明人： ALTMAN, Michael D. , ANDRESEN, Brian M. , BRUBAKER, Jason D. , CHILDERS, Matthew L. , DONOFRIO, Anthony , FISCHMANN, Thierry , GIBEAU, Craig R. , KATTAR, Solomon D. , LESBURG, Charles A. , LIM, Jongwon , MACLEAN, John K. F. , MANSOOR, Umar F. , NORTHRUP, Alan B. , SANDERS, John M. , SMITH, Graham F. , TORRES, Luis
IPC分类号： A61K31/444 , A61K31/506 , A61K45/06 , A61P37/00 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/14
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公开(公告)号：EP3200787A1
公开(公告)日：2017-08-09
申请号：EP15846218.4
申请日：2015-09-25
发明人： ALTMAN, Michael D. , ANDRESEN, Brian M. , BRUBAKER, Jason D. , CHILDERS, Matthew L. , DONOFRIO, Anthony , FISCHMANN, Thierry , GIBEAU, Craig R. , KATTAR, Solomon D. , LESBURG, Charles A. , LIM, Jongwon , MACLEAN, John K. F. , MANSOOR, Umar F. , NORTHRUP, Alan B. , SANDERS, John M. , SMITH, Graham F. , TORRES, Luis
IPC分类号： A61K31/444 , A61K31/506 , A61K45/06
CPC分类号： C07D498/04 , A61K31/517 , A61K31/5377 , A61K31/5383 , A61K45/06 , A61P37/00 , C07D239/94 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/048 , A61K2300/00
摘要： The present invention relates to inhibitors of IRAK4 of Formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
摘要翻译： 本发明涉及式（I）的IRAK4的抑制剂并提供包含此类抑制剂的组合物，以及用于治疗IRAK4介导的或相关病症或疾病的方法。
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公开(公告)号：EP2513098B1
公开(公告)日：2016-11-09
申请号：EP10801736.9
申请日：2010-12-15
发明人： ALTMANN, Michael D. , ANDRESEN, Brian M. , ARRINGTON, Kenneth L. , CHILDERS, Kaleen Konrad , DI FRANCESCO, Maria Emilia , DONOFRIO, Anthony , ELLIS, John Michael , FISCHER, Christian , GUERIN, David Joseph , HAIDLE, Andrew M. , KATTAR, Solomon , KNOWLES, Sandra Lee , LI, Chaomin , LIM, Jongwon , MACHACEK, Michelle , NORTHRUP, Alan B. , O'BOYLE, Brendan M. , OTTE, Ryan D. , PETROCCHI, Alessia , REUTERSHAN, Michael H. , ROMEO, Eric , SIU, Tony , TAOKA, Brandon M. , TROTTER, B. Wesley , ZHOU, Hua , BURCH, Jason , COTE, Bernard , DUPONT-GAUDET, Kristina , FOURNIER, Jean-Francois , GAUTHIER, Jacques Yves , GUAY, Daniel , ROBICHAUD, Joel S. , GRIMM, Jonathan , MADDESS, Matthew L. , SCHELL, Adam J. , SPENCER, Kerrie B. , WOO, Hyun Chong , BHAT, Sathesh
IPC分类号： C07D417/12 , C07D417/14 , A61K31/497 , A61P11/00 , A61P11/06 , A61P29/00 , A61P35/00
CPC分类号： C07D417/12 , C07D417/14 , C07D451/06 , C07D471/04 , C07D471/08 , C07D487/04 , C07D491/08 , C07D495/04 , C07F9/65583
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公开(公告)号：EP3200790B1
公开(公告)日：2020-08-26
申请号：EP15847644.0
申请日：2015-09-25
发明人： ALTMAN, Michael D. , ANDRESEN, Brian M. , BRUBAKER, Jason D. , DONOFRIO, Anthony , FISCHMANN, Thierry , GIBEAU, Craig R. , LESBURG, Charles A. , LIM, Jongwon , MACLEAN, John K. F. , MANSOOR, Umar F. , NORTHRUP, Alan B. , SANDERS, John M. , SMITH, Graham F. , TORRES, Luis
IPC分类号： A61K31/444 , A61K31/506 , A61K45/06 , A61P29/00 , A61P35/00 , C07D239/94 , C07D405/04
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公开(公告)号：EP3280419B1
公开(公告)日：2019-10-30
申请号：EP16777095.7
申请日：2016-04-04
发明人： SIU, Tony , ALTMAN, Michael D. , ANDRESEN, Brian M. , LIU, Jian , KOZLOWSKI, Joseph , BOGA, Sobhana Babu , YU, Younong , ANAND, Rajan , CAI, Jiaqiang , WANG, Dahai , LIU, Shilan
IPC分类号： A61K31/55 , A61K31/501 , A61K31/506 , C07D401/14 , C07D405/14 , C07D413/14 , A61P19/02
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公开(公告)号：EP3083559A1
公开(公告)日：2016-10-26
申请号：EP14872226.7
申请日：2014-12-18
发明人： ANDRESEN, Brian M. , ARRINGTON, Kenneth L. , OTTE, Ryan D. , ELLIS, John Michael , BUTCHER, John W. , NORTHRUP, Alan B. , ROBICHAUD, Joel S. , GAUTHIER, Jacques Yves , FOURNIER, Jean-Francois
IPC分类号： C07D213/72
CPC分类号： C07D417/14 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D417/12
摘要： The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein ring R
1 , R
2 , R
3 , R
4 , ring B, and the subscript r are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).摘要翻译： 本发明提供式（I）的某些噻唑取代的氨基杂芳基化合物或其药学上可接受的盐，其中R1，R2，R3，R4，环B和下标r如本文所定义。 本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）介导的疾病或病症的方法。
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