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公开(公告)号：EP3914587A1
公开(公告)日：2021-12-01
申请号：EP19909987.0
申请日：2019-12-19
发明人： MILLER, Randall R. , KOZLOWSKI, Joseph A. , NANTERMET, Philippe , OLSEN, David B. , SU, Jing , YANG, Lihu , SUZUKI, Takao , CROWLEY, Brendan M. , WANG, Nengxue , YOU, Lanying
IPC分类号： C07D263/20 , C07D413/14 , C07D417/14 , A61K31/42 , A61K31/422 , A61P31/00 , A61P31/06
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公开(公告)号：EP4013742A1
公开(公告)日：2022-06-22
申请号：EP20852190.6
申请日：2020-07-21
申请人： Merck Sharp & Dohme Corp. , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , MSD R&D (China) Co., Ltd.
发明人： MCCAULEY, John A. , COWMAN, Alan F. , DE LERA RUIZ, Manuel , FAVUZZA, Paola , GUO, Zhuyan , HU, Bin , KELLY III, Michael J. , LEI, Zhiyu , OLSEN, David B. , SLEEBS, Brad , THOMPSON, Jennifer K. , TRIGLIA, Tony , ZHAN, Dongmei , ZHANG, Cailing , ZHAO, Lianyun
IPC分类号： C07D239/22 , C07D405/04 , C07D405/14 , A61K31/513 , A61P33/06
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公开(公告)号：EP3209667A1
公开(公告)日：2017-08-30
申请号：EP15853228.3
申请日：2015-10-21
发明人： YOUNG, Katherine , OLSEN, David B. , SINGH, Sheo B. , SU, Jing , WILKENING, Robert R. , APGAR, James M. , MENG, Dongfang , PARKER, Dann , MANDAL, Mihir , YANG, Lihu , PAINTER, Ronald E. , DANG, Qun , SUZUKI, Takao
IPC分类号： C07D493/10
CPC分类号： C07D493/08 , C07C53/18 , C07C309/06 , C07D493/18 , C07D519/00 , C07F7/1856
摘要： The present invention relates to novel nargenicin related compounds which can inhibit DnaE and have antibacterial, particularly antimycobacterial activity against Mycobacterium tuberculosis. The present invention also relates to method for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis by administering an antimycobacterially effective amount of nargenicin or a nargenicin-related compound and/or their pharmaceutically acceptable salts.
摘要翻译： 本发明涉及新的可以抑制DnaE并具有抗细菌特别是抗结核分枝杆菌的抗分枝杆菌活性的Nargenicin相关化合物。 本发明还涉及抑制分枝杆菌细胞生长的方法以及通过施用抗分枝杆菌有效量的Nargenicin或Narragein相关化合物和/或其药学上可接受的盐来治疗结核分枝杆菌的分枝杆菌感染的方法。
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