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公开(公告)号：EP4253412A3
公开(公告)日：2023-11-22
申请号：EP23173594.5
申请日：2016-12-16
IPC分类号： A61K35/17 , A61K38/17 , A61K31/7088 , A61K39/395 , A61P35/00 , A61P31/12 , A61P37/04 , G01N33/566 , A61K31/506 , A61K31/713 , C07K16/18 , A61K39/00 , A61P35/02 , C07K16/28 , G01N33/68 , C07K16/22
摘要： The present invention relates to therapeutic and prophylactic methods based on inhibition of CIS in NK cells. In particular, the present invention relates to treating or preventing a NK-responsive condition by administering to a subject a CIS inhibitor, or administering CIS-inhibited NK cells. The invention further relates to methods for identifying a CIS inhibitor, and for determining a likelihood of cancer response to treatment with CIS inhibition
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公开(公告)号：EP3873461A1
公开(公告)日：2021-09-08
申请号：EP19879746.6
申请日：2019-10-31
发明人： MASTERS, Seth , YU, Chien-Hsiung
IPC分类号： A61K31/404 , A61K31/4184 , A61P25/28
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3.发明授权
公开(公告)号：EP3456338B1
公开(公告)日：2020-07-29
申请号：EP18193427.4
申请日：2012-11-15
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公开(公告)号：EP3487876A1
公开(公告)日：2019-05-29
申请号：EP17830123.0
申请日：2017-07-21
申请人： University of Utah Research Foundation , The Walter and Eliza Hall Institute of Medical Research
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公开(公告)号：EP3307258A1
公开(公告)日：2018-04-18
申请号：EP16729240.8
申请日：2016-06-09
发明人： VOSS, Anne Kathrin , BAELL, Jonathan , NGUYEN, Huu Nghi , LEAVER, David J. , CLEARY, Benjamin L. , LAGIAKOS, H. Rachel , SHEIKH, Bilal Nadeem , THOMAS, Timothy John
IPC分类号： A61K31/145 , A61K31/341 , A61K31/38 , A61K31/395 , C07D213/87 , C07D231/12 , C07D231/16 , C07D333/24 , C07C311/49 , C07D237/08 , C07D249/06 , C07D271/06 , C07D271/10 , C07D277/30 , C07D213/54 , C07D307/54 , A61P35/02
CPC分类号： C07C311/49 , A61P35/00 , C07C2601/02 , C07C2601/08 , C07C2601/16 , C07C2602/10 , C07D213/56 , C07D213/86 , C07D213/87 , C07D231/12 , C07D231/16 , C07D237/08 , C07D239/26 , C07D249/06 , C07D271/06 , C07D271/10 , C07D277/30 , C07D307/54 , C07D333/24
摘要： where X1 is either CRF2 or N, where RF2 is H or F; X2 is either CR3 or N, where R3 is selected from H, Me, Cl, F OMe; X3 is either CH or N; X4 is either CRF3 or N, where RF3 is H or F; where only one or two of X1, X2, X3 and X4 may be N; and R4 is selected from I, optionally substituted phenyl, optionally substituted C5-6 heteroaryl; optionally substituted C1-6 alkyl and optionally substituted C1-6 alkoxy, which are useful in the treatment of a condition ameliorated by the inhibition of MOZ.
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6.发明授权THERAPEUTIC PRO-APOPTOTIC BH3-LIKE MOLECULES AND METHODS FOR GENERATING AND/OR SELECTING THE SAME 有权治疗性促凋亡BH3样分子和方法用于产生和/或选择它
公开(公告)号：EP1910535B1
公开(公告)日：2016-08-17
申请号：EP06752632.7
申请日：2006-06-23
发明人： COLMAN, Peter, Malcolm , HUANG, David, Ching, Siang , LEE, Erinna, Faith , FAIRLIE, Walter, Douglas
IPC分类号： C12N15/01 , A61P35/00 , A61K38/17 , C07K14/435
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公开(公告)号：EP2373163B1
公开(公告)日：2015-06-10
申请号：EP09837920.9
申请日：2009-12-17
发明人： BAELL, Jonathan, Bayldon , BUI, Chinh, Thien , COLMAN, Peter , CZABOTAR, Peter , DUDLEY, Danette, A. , FAIRBROTHER, Wayne, J. , FLYGARE, John, A. , LESSENE, Guillaume, Laurent , NDUBAKU, Chudi , NIKOLAKOPOULOS, George , SLEEBS, Brad, Edmund , SMITH, Brian, John , WATSON, Keith, Geoffrey , ELMORE, Steven, W. , HASVOLD, Lisa, A. , PETROS, Andrew, M. , SOUERS, Andrew, J. , TAO, Zhi-Fu , WANG, Le , WANG, Xilu , DESHAYES, Kurt
IPC分类号： A01N43/00 , C07D417/14 , C07D471/06 , C07D487/04 , C07D513/06 , C07D495/04 , C07D473/00 , C07D513/04
CPC分类号： C07D417/14 , C07D471/06 , C07D473/00 , C07D487/04 , C07D495/04 , C07D513/04 , C07D513/06
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公开(公告)号：EP2376085B1
公开(公告)日：2014-02-26
申请号：EP09837907.6
申请日：2009-12-17
发明人： BAELL, Jonathan, Bayldon , BUI, Chinh, Thien , COLMAN, Peter , DUDLEY, Danette, A. , FAIRBROTHER, Wayne, J. , FLYGARE, John, A. , LESSENE, Guillaume, Laurent , NDUBAKU, Chudi , NIKOLAKOPOULOS, George , RYE, Carl, Steven , SLEEBS, Brad, Edmund , SMITH, Brian, John , WATSON, Keith, Geoffrey , ELMORE, Steven, W. , PETROS, Andrew, M. , SOUERS, Andrew, J. , CZABOTAR, Peter
IPC分类号： A61K31/535 , C07D417/14 , C07D487/04
CPC分类号： C07D417/14 , C07D417/12 , C07D487/04
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9.发明公开Therapeutic pro-apoptotic BH3-like molecules and methods for generating and/or selecting the same 有权治疗促凋亡BH3样分子以及它们的生产和/或选择方法
公开(公告)号：EP2407484A3
公开(公告)日：2012-04-25
申请号：EP11178210.8
申请日：2006-06-23
IPC分类号： C07K14/47
摘要： The present invention relates generally to therapeutic molecules which are useful for modulating apoptosis in a target cell or cell population. More particularly, the present invention provides therapeutic agents which inhibit pro-survival molecules and which are capable of inducing or facilitates apoptosis of a target cell or cell population such as cancer cells. Further provided are methods for generating or selecting the therapeutic molecules and pharmaceutical compositions comprising the therapeutic molecules.
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公开(公告)号：EP2195346A1
公开(公告)日：2010-06-16
申请号：EP08783037.8
申请日：2008-08-29
发明人： LAHOUD, Mireille Hanna , PROIETTO, Anna Irene , CAMINSCHI, Irina , SHORTMAN, Ken , LEW, Andrew Mark , WU, Li , WRIGHT, Mark Dexter
CPC分类号： C07K14/705 , A61K39/385 , A61K39/39 , A61K47/6849 , A61K51/1027 , A61K2039/6056 , C07K14/7056 , C07K16/18 , C07K2317/73 , C12N15/8258 , G01N33/5005 , G01N33/5047 , G01N2333/42 , G01N2333/4724 , G06F19/16 , Y02A50/412
摘要： The present invention relates to the identification of proteins located on the cell surface of dendritic cells or precursors thereof, particularly antigen presenting dendritic cells. In particular, the present invention relates to compounds such as antibodies that bind these proteins. These compounds can be used to detect and/or enrich a subset of dendritic cells or precursors thereof. These compounds can also be used to target antigens to dendritic cells or precursors thereof to modulate a humoral and/or T cell mediated immune response to an antigen, or used to target cytotoxic agents to dendritic cells or precursors thereof involved in diseased states.
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