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1.发明公开
公开(公告)号：EP3558310A1
公开(公告)日：2019-10-30
申请号：EP17884553.3
申请日：2017-12-18
发明人： BAO, Jianming , FERGUSON, Ronald , GAO, Xiaolei , HARRISON, Scott , KNOWLES, Sandra, L. , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , SCHUBERT, Jeffrey, W.
IPC分类号： A61K31/445 , A61K31/495 , A61K31/496 , C07D401/00 , C07D401/02 , C07D401/04
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2.发明公开
公开(公告)号：EP3394061A1
公开(公告)日：2018-10-31
申请号：EP16826815.9
申请日：2016-12-21
发明人： BAO, Jianming , GAO, Xiaolei , KNOWLES, Sandra, L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , ONDEYKA, Debra, L. , STAMFORD, Andrew, W. , ZHANG, Fengqi
IPC分类号： C07D471/04 , C07D519/00 , C07F9/22 , A61K31/437 , A61P25/00
CPC分类号： C07D471/04 , C07D471/08 , C07D491/048 , C07D491/052 , C07D519/00 , C07F9/222 , C07F9/6561
摘要： The present invention is directed to 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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3.发明公开
公开(公告)号：EP3644991A1
公开(公告)日：2020-05-06
申请号：EP18824389.3
申请日：2018-06-22
发明人： ACTON, John, J., III , BAO, Jianming , DENG, Qiaolin , EGBERTSON, Melissa , FERGUSON, Ronald, III , GAO, Xiaolei , HARRISON, Scott Timothy , HENDERSON, Timothy, J. , KNOWLES, Sandra, L. , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , NA, Meng , SELYUTIN, Oleg, B. , SUZUKI, Takao , ZHANG, Fengqi
IPC分类号： A61K31/4155 , C07D231/10 , C07D471/04
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公开(公告)号：EP3394061B1
公开(公告)日：2020-03-11
申请号：EP16826815.9
申请日：2016-12-21
发明人： BAO, Jianming , GAO, Xiaolei , KNOWLES, Sandra, L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , ONDEYKA, Debra, L. , STAMFORD, Andrew, W. , ZHANG, Fengqi
IPC分类号： C07D471/04 , C07D519/00 , C07F9/22 , A61K31/437 , A61P25/00
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5.发明公开
公开(公告)号：EP3558307A1
公开(公告)日：2019-10-30
申请号：EP17885368.5
申请日：2017-12-18
发明人： GAO, Xiaolei , KNOWLES, Sandra, L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , TONG, Ling
IPC分类号： A61K31/435 , A61K31/436 , A61K31/445 , C07D401/00 , C07D401/02 , C07D401/14
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公开(公告)号：EP2320737B1
公开(公告)日：2013-07-17
申请号：EP09805356.4
申请日：2009-07-27
发明人： KATZ, Jason , KNOWLES, Sandra, L. , JEWELL, James, P. , SLOMAN, David, L. , STANTON, Matthew, G. , NOUCTI, Njamkou
IPC分类号： C07D417/04 , C07D417/14 , A61K31/425 , A01N43/78
CPC分类号： A61K31/425 , C07D417/04 , C07D417/14
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7.发明公开
公开(公告)号：EP3558306A1
公开(公告)日：2019-10-30
申请号：EP17883963.5
申请日：2017-12-18
发明人： GAO, Xiaolei , KNOWLES, Sandra, L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert, D., Jr. , ONDEYKA, Debra, L.
IPC分类号： A61K31/4196 , A61K31/435 , A61K31/445 , C07D249/08 , C07D401/02 , C07D401/04
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