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公开(公告)号：EP2706852B1
公开(公告)日：2018-08-22
申请号：EP12782391.2
申请日：2012-05-04
发明人： DESCHENES, Denis , ALTMAN, Michael D. , ELLIS, John Michael , FISCHER, Christian , HAIDLE, Andrew M. , KATTAR, Solomon D. , NORTHRUP, Alan B. , SCHELL, Adam J. , SMITH, Graham F. , TAOKA, Brandon M. , BIENSTOCK, Corey , DI FRANCESCO, Maria Emilia , DONOFRIO, Anthony , PETERSON, Scott , SPENCER, Kerrie B. , JEWELL, James Patrick , ALI, Amjad , BENNETT, David Jonathan , DANG, Qun , WAI, John
IPC分类号： A01N43/40 , A61K31/44 , C07D213/04
CPC分类号： C07D401/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04
摘要： The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, or are prodrugs thereof, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis and cancer.
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公开(公告)号：EP2706852A1
公开(公告)日：2014-03-19
申请号：EP12782391.2
申请日：2012-05-04
发明人： DESCHENES, Denis , ALTMAN, Michael D. , ELLIS, John Michael , FISCHER, Christian , HAIDLE, Andrew M. , KATTAR, Solomon D. , NORTHRUP, Alan B. , SCHELL, Adam J. , SMITH, Graham F. , TAOKA, Brandon M. , BIENSTOCK, Corey , DI FRANCESCO, Maria Emilia , DONOFRIO, Anthony , PETERSON, Scott , SPENCER, Kerrie B. , JEWELL, James Patrick , ALI, Amjad , BENNETT, David Jonathan , DANG, Qun , WAL, John
IPC分类号： A01N43/40 , A61K31/44 , C07D213/04
CPC分类号： C07D401/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04
摘要： The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, or are prodrugs thereof, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis and cancer.
摘要翻译： 本发明提供了式I的新型嘧啶胺，它们是脾酪氨酸激酶的有效抑制剂，或者是其前药，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD和类风湿性关节炎和癌症。
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公开(公告)号：EP3200789B1
公开(公告)日：2019-11-06
申请号：EP15847222.5
申请日：2015-09-25
发明人： ALTMAN, Michael D. , BRUBAKER, Jason D. , CHILDERS, Matthew L. , DONOFRIO, Anthony , FISCHMANN, Thierry , GIBEAU, Craig R. , KATTAR, Solomon D. , LESBURG, Charles A. , LIM, Jongwon , MACLEAN, John K. F. , MANSOOR, Umar F. , NORTHRUP, Alan B. , SANDERS, John M. , SMITH, Graham F.
IPC分类号： A61K31/444 , A61K31/506 , A61K45/06 , A61P29/00 , A61P35/00 , C07D403/12 , C07D239/94 , C07D239/88 , C07D401/12 , C07D405/12
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公开(公告)号：EP3200790A1
公开(公告)日：2017-08-09
申请号：EP15847644.0
申请日：2015-09-25
发明人： ALTMAN, Michael D. , ANDRESEN, Brian M. , BRUBAKER, Jason D. , DONOFRIO, Anthony , FISCHMANN, Thierry , GIBEAU, Craig R. , LESBURG, Charles A. , LIM, Jongwon , MACLEAN, John K. F. , MANSOOR, Umar F. , NORTHRUP, Alan B. , SANDERS, John M. , SMITH, Graham F. , TORRES, Luis
IPC分类号： A61K31/444 , A61K31/506 , A61K45/06
CPC分类号： A61K31/517 , A61K45/06 , A61P29/00 , A61P35/00 , C07D239/94 , C07D405/04 , A61K2300/00
摘要： The present invention relates to inhibitors of IRAK4 of Formula I and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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公开(公告)号：EP3200790B1
公开(公告)日：2020-08-26
申请号：EP15847644.0
申请日：2015-09-25
发明人： ALTMAN, Michael D. , ANDRESEN, Brian M. , BRUBAKER, Jason D. , DONOFRIO, Anthony , FISCHMANN, Thierry , GIBEAU, Craig R. , LESBURG, Charles A. , LIM, Jongwon , MACLEAN, John K. F. , MANSOOR, Umar F. , NORTHRUP, Alan B. , SANDERS, John M. , SMITH, Graham F. , TORRES, Luis
IPC分类号： A61K31/444 , A61K31/506 , A61K45/06 , A61P29/00 , A61P35/00 , C07D239/94 , C07D405/04
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公开(公告)号：EP3200787B1
公开(公告)日：2019-09-04
申请号：EP15846218.4
申请日：2015-09-25
发明人： ALTMAN, Michael D. , ANDRESEN, Brian M. , BRUBAKER, Jason D. , CHILDERS, Matthew L. , DONOFRIO, Anthony , FISCHMANN, Thierry , GIBEAU, Craig R. , KATTAR, Solomon D. , LESBURG, Charles A. , LIM, Jongwon , MACLEAN, John K. F. , MANSOOR, Umar F. , NORTHRUP, Alan B. , SANDERS, John M. , SMITH, Graham F. , TORRES, Luis
IPC分类号： A61K31/444 , A61K31/506 , A61K45/06 , A61P37/00 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/14
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公开(公告)号：EP3200789A1
公开(公告)日：2017-08-09
申请号：EP15847222.5
申请日：2015-09-25
发明人： ALTMAN, Michael D. , BRUBAKER, Jason D. , CHILDERS, Matthew L. , DONOFRIO, Anthony , FISCHMANN, Thierry , GIBEAU, Craig R. , KATTAR, Solomon D. , LESBURG, Charles A. , LIM, Jongwon , MACLEAN, John K. F. , MANSOOR, Umar F. , NORTHRUP, Alan B. , SANDERS, John M. , SMITH, Graham F.
IPC分类号： A61K31/444 , A61K31/506 , A61K45/06
摘要： The present invention relates to inhibitors of IRAK4 of Formula I and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
摘要翻译： 本发明涉及式I的IRAK4的抑制剂并提供了包含这种抑制剂的组合物，以及用于治疗IRAK4介导的或相关的病症或疾病的方法。
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公开(公告)号：EP3200787A1
公开(公告)日：2017-08-09
申请号：EP15846218.4
申请日：2015-09-25
发明人： ALTMAN, Michael D. , ANDRESEN, Brian M. , BRUBAKER, Jason D. , CHILDERS, Matthew L. , DONOFRIO, Anthony , FISCHMANN, Thierry , GIBEAU, Craig R. , KATTAR, Solomon D. , LESBURG, Charles A. , LIM, Jongwon , MACLEAN, John K. F. , MANSOOR, Umar F. , NORTHRUP, Alan B. , SANDERS, John M. , SMITH, Graham F. , TORRES, Luis
IPC分类号： A61K31/444 , A61K31/506 , A61K45/06
CPC分类号： C07D498/04 , A61K31/517 , A61K31/5377 , A61K31/5383 , A61K45/06 , A61P37/00 , C07D239/94 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/048 , A61K2300/00
摘要： The present invention relates to inhibitors of IRAK4 of Formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
摘要翻译： 本发明涉及式（I）的IRAK4的抑制剂并提供包含此类抑制剂的组合物，以及用于治疗IRAK4介导的或相关病症或疾病的方法。
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