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1.发明授权SPIROPIPERIDINE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHERMER S DISEASE 有权螺哌啶化合物作为阿尔茨海默氏病的治疗β-分泌酶抑制剂
公开(公告)号：EP1804794B1
公开(公告)日：2013-07-31
申请号：EP05812233.4
申请日：2005-10-12
发明人： BARROW, James, C. , COBURN, Craig, A. , EGBERTSON, Melissa, S. , MCGAUGHEY, Georgia, B. , MCWHERTER, Melody, A. , NEILSON, Lou, Anne , SELNICK, Harold, G. , STAUFFER, Shaun, R. , YANG, Zhi-Qiang , YANG, Wenjin , LU, Wanli , FAHR, Bruce , RITTLE, Kenneth, E.
IPC分类号： A61K31/438 , C07D401/04
CPC分类号： C07D471/10
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2.发明授权SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权SPIROPIPERIDININHIBITORENβ-分泌阿尔茨海默氏病的治疗
公开(公告)号：EP1910364B1
公开(公告)日：2012-03-21
申请号：EP06787495.8
申请日：2006-07-14
发明人： COBURN, Craig, A. , EGBERTSON, Melissa, S. , GRAHAM, Samuel, L. , MCGAUGHEY, Georgia, B. , STAUFFER, Shaun, R. , RAJAPAKSE, Hemaka, A. , NANTERMET, Philippe, G. , STACHEL, Shawn, R. , YANG, Wenjin , LU, Wanli , FAHR, Bruce
IPC分类号： C07D471/10 , A61K31/438 , A61P25/28
CPC分类号： C07D471/10
摘要： The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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3.发明授权PHENYLAMIDE AND PYRIDYLAMIDE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权阿尔茨海默氏病的治疗PHENYLAMID-和吡啶酰胺，β-分泌酶抑制剂
公开(公告)号：EP1697308B1
公开(公告)日：2014-03-19
申请号：EP04814367.1
申请日：2004-12-15
发明人： BARROW, James, C. , COBURN, Craig, A. , NANTERMET, Philippe, G. , SELNICK, Harold, G. , STACHEL, Shawn, J. , STANTON, Matthew, G. , STAUFFER, Shaun, R. , ZHUANG, Linghang , DAVIS, Jennifer, R.
IPC分类号： C07D213/81 , C07C237/00 , C07D213/02 , A61K31/18 , A61K31/44 , C07D401/04 , A61P25/28
CPC分类号： C07D213/81 , C07D213/75 , C07D257/04 , C07D401/04 , C07D409/12 , C07D413/12
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4.发明授权SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权SPIROPIPERIDININHIBITORENβ-分泌阿尔茨海默氏病的治疗
公开(公告)号：EP2091328B1
公开(公告)日：2011-12-28
申请号：EP07853004.5
申请日：2007-10-29
CPC分类号： C07D471/10
摘要： The present invention is directed to spiropiperidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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5.发明授权PIPERIDINE AND PYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权哌啶和吡咯烷β-分泌酶抑制剂用于治疗阿尔茨海默氏病的治疗
公开(公告)号：EP2077719B1
公开(公告)日：2011-12-28
申请号：EP07838507.7
申请日：2007-09-19
发明人： STAUFFER, Shaun, R.
IPC分类号： A61K31/55 , A61K31/435 , A61K31/454 , A61K31/496 , A61K31/4545 , A61K31/4439 , A61P25/28
CPC分类号： C07D413/04 , C07D401/12 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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6.发明授权1,3,5-SUBSTITUTED PHENYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权用于治疗阿尔茨海默病SUITABLE 1,3,5-取代PHENYLDERIVATVERBINDUNGEN的治疗ALSβ-分泌酶抑制剂
公开(公告)号：EP1740559B1
公开(公告)日：2014-10-15
申请号：EP05738682.3
申请日：2005-04-15
发明人： BARROW, James, C. , MCGAUGHEY, Georgia, B. , NANTERMET, Philippe, G. , RAJAPAKSE, Hemaka, A. , SELNICK, Harold, G. , STAUFFER, Shaun, R. , COBURN, Craig, A.
IPC分类号： C07D271/10 , A61K31/4245 , A61P25/28
CPC分类号： C07D271/10 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/62 , C07D271/06 , C07D285/12 , C07D307/14 , C07D307/42 , C07D307/44 , C07D307/52 , C07D307/54 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
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7.发明授权2, 4, 6-SUBSTITUTED PYRIDYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权β-分泌酶抑制剂用于治疗阿尔茨海默病SUITABLE 2,4,6-取代PYRIDYLDERIVATVERBINDUNGEN的治疗
公开(公告)号：EP1740581B1
公开(公告)日：2012-08-22
申请号：EP05737506.5
申请日：2005-04-20
发明人： BARROW, James, C. , MCGAUGHEY, Georgia, B. , NANTERMET, Philippe, G. , RAJAPAKSE, Hemaka, A. , SELNICK, Harold, G. , STAUFFER, Shaun, R. , VACCA, Joseph, P. , STACHEL, Shawn, J. , COBURN, Craig, A. , STANTON, Matthew, G.
IPC分类号： C07D401/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
CPC分类号： C07D413/04 , C07D401/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention is directed to 2, 4, 6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer’s disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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公开(公告)号：EP2410857B1
公开(公告)日：2014-01-29
申请号：EP10756586.3
申请日：2010-03-15
发明人： BURGEY, Christopher, S. , DENG, Zhengwu, J. , NGUYEN, Diem, N. , PAONE, Daniel, V. , POTTEIGER, Craig, M. , STAUFFER, Shaun, R. , SEGERDELL, Carolyn , NOMLAND, Ashley , LIM, John, J.
IPC分类号： A01N43/64 , A01N43/52 , A61K31/415 , C07D413/12 , C07D471/04 , A61K33/00 , A61K31/195 , A61K45/06
CPC分类号： C07D471/04 , A61K31/195 , A61K31/415 , A61K33/00 , A61K45/06 , C07D413/12 , A61K2300/00
摘要： The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.
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9.发明授权BICYCLIC SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权双环螺哌啶β-分泌酶抑制剂用于治疗阿尔茨海默氏病的治疗
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公开(公告)号：EP2410857A1
公开(公告)日：2012-02-01
申请号：EP10756586.3
申请日：2010-03-15
发明人： BURGEY, Christopher, S. , DENG, Zhengwu, J. , NGUYEN, Diem, N. , PAONE, Daniel, V. , POTTEIGER, Craig, M. , STAUFFER, Shaun, R. , SEGERDELL, Carolyn , NOMLAND, Ashley , LIM, John, J.
IPC分类号： A01N43/64 , A01N43/52 , A61K31/415
CPC分类号： C07D471/04 , A61K31/195 , A61K31/415 , A61K33/00 , A61K45/06 , C07D413/12 , A61K2300/00
摘要： The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.
摘要翻译： 本发明涉及新型P2X 3受体拮抗剂，其在治疗与疼痛相关的疾病状态中发挥关键作用，所述疾病状态特别是可用P2X 3受体亚单位调节剂治疗的外周疼痛，炎性疼痛或组织损伤疼痛。
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