公开(公告)号：EP1804794B1

公开(公告)日：2013-07-31

申请号：EP05812233.4

申请日：2005-10-12

申请人： Merck Sharp & Dohme Corp. ,  Sunesis Pharmaceuticals, Inc.

发明人： BARROW, James, C. ,  COBURN, Craig, A. ,  EGBERTSON, Melissa, S. ,  MCGAUGHEY, Georgia, B. ,  MCWHERTER, Melody, A. ,  NEILSON, Lou, Anne ,  SELNICK, Harold, G. ,  STAUFFER, Shaun, R. ,  YANG, Zhi-Qiang ,  YANG, Wenjin ,  LU, Wanli ,  FAHR, Bruce ,  RITTLE, Kenneth, E.

IPC分类号： A61K31/438 ,  C07D401/04

CPC分类号： C07D471/10

公开(公告)号：EP2512243B1

公开(公告)日：2016-04-06

申请号：EP10841821.1

申请日：2010-12-13

申请人： Merck Sharp & Dohme Corp.

发明人： KUDUK, Scott, D. ,  SCHLEGEL, Kelly-Ann ,  YANG, Zhi-Qiang

IPC分类号： C07D413/10 ,  C07D401/04 ,  C07D401/10 ,  C07D417/10 ,  C07D215/48 ,  C07D215/60 ,  C07D401/06 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/14

CPC分类号： C07D215/60 ,  C07D215/48 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04

公开(公告)号：EP2010493B1

公开(公告)日：2016-01-27

申请号：EP07775220.2

申请日：2007-04-11

申请人： Merck Sharp & Dohme Corp.

发明人： BARROW, James, C. ,  BIEBER, Kelly-Ann, S. Merck & Co., Inc. ,  CUBE, Rowena, V. ,  MATTERN, Mamio Christa Merck & Co., Inc. ,  REGER, Thomas, S. ,  SHU, Youheng ,  YANG, Zhi-Qiang

IPC分类号： C07D213/40

CPC分类号： C07D413/12 ,  C07D213/40 ,  C07D213/61 ,  C07D213/65 ,  C07D213/73 ,  C07D213/74 ,  C07D213/75 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D411/12

公开(公告)号：EP2212291B1

公开(公告)日：2014-06-04

申请号：EP08843270.3

申请日：2008-10-23

申请人： Merck Sharp & Dohme Corp.

发明人： BARROW, James, C. ,  COLEMAN, Paul, J. ,  REGER, Thomas, S. ,  SCHLEGEL, Kelly-ann, S. ,  SHU, Youheng ,  YANG, Zhi-Qiang

IPC分类号： C07D213/65 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  A61K31/44 ,  A61P25/08

CPC分类号： C07D401/12 ,  C07D213/65 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04

公开(公告)号：EP2211864A1

公开(公告)日：2010-08-04

申请号：EP08842894.1

申请日：2008-10-23

申请人： Merck Sharp & Dohme Corp.

发明人： BARROW, James, C. ,  YANG, Zhi-Qiang

IPC分类号： A61K31/4965

CPC分类号： C07D241/12 ,  C07D241/16 ,  C07D241/18

摘要： The present invention is directed to pyrazinyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

公开(公告)号：EP3206687A1

公开(公告)日：2017-08-23

申请号：EP15850726.9

申请日：2015-10-09

申请人： Merck Sharp & Dohme Corp.

发明人： STAMFORD, Andrew, W. ,  YANG, Zhi-Qiang ,  MALETIC, Milana ,  CAI, Senlin ,  DUAN, Xiaobang ,  CAO, Jianhua

IPC分类号： A61K31/44 ,  A61K33/16 ,  C07D277/62

CPC分类号： C07D417/06 ,  A61K31/4439 ,  A61K31/444 ,  C07D417/14

摘要： The present invention relates to cyclic sulfonamide derivatives of Formula (I) or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及式（I）的环磺酰胺衍生物或其药学上可接受的盐。

公开(公告)号：EP2709621A1

公开(公告)日：2014-03-26

申请号：EP12786166.4

申请日：2012-05-11

申请人： Merck Sharp & Dohme Corp.

发明人： KUDUK, Scott, D. ,  DIMARCO, Christina Ng ,  YANG, Zhi-Qiang

IPC分类号： A61K31/4709

CPC分类号： C07D405/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

摘要： The present invention is directed to N-linked quinoline amide compounds of general formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

公开(公告)号：EP2493297A1

公开(公告)日：2012-09-05

申请号：EP10827361.6

申请日：2010-10-25

申请人： Merck Sharp & Dohme Corp.

发明人： SCHLEGEL, Kelly-Ann ,  SHU, Yoheng ,  YANG, Zhi-Qiang ,  BARROW, James

IPC分类号： A01N37/12 ,  A01N37/18 ,  A61K31/16

CPC分类号： C07D401/06 ,  C07D233/64 ,  C07D249/04 ,  C07D257/04 ,  C07D263/32 ,  C07D271/10 ,  C07D271/113 ,  C07D277/28 ,  C07D413/04 ,  C07D413/06 ,  C07D417/14

摘要： The present invention is directed to heterocycle amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

公开(公告)号：EP2175725A1

公开(公告)日：2010-04-21

申请号：EP08779992.0

申请日：2008-07-07

申请人： Merck Sharp & Dohme Corp.

发明人： BARROW, James, C. ,  YANG, Zhi-Qiang

IPC分类号： A01N43/54 ,  A61K31/517

CPC分类号： C07D401/06 ,  C07D239/82 ,  C07D413/06

摘要： The present invention is directed to quinazolinone compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

公开(公告)号：EP2709621B1

公开(公告)日：2016-11-02

申请号：EP12786166.4

申请日：2012-05-11

申请人： Merck Sharp & Dohme Corp.

发明人： KUDUK, Scott, D. ,  DIMARCO, Christina Ng ,  YANG, Zhi-Qiang

IPC分类号： A61K31/4709 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D401/06 ,  A61P25/28

CPC分类号： C07D405/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12