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    INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE
    5.
    发明公开
    INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE 有权
    杀虫剂4-氨基噻吩并[2,3-D] -PYRIMIDINVERBINDUNGEN AND其生产和使用

    公开(公告)号：EP2459569A1

    公开(公告)日：2012-06-06

    申请号：EP10745045.4

    申请日：2010-07-29

    申请人： Merial Limited

    发明人： SOLL, Mark, David ,  MENG, Charles, Q.

    IPC分类号： C07D495/04 ,  A01N43/90 ,  A01P7/00

    CPC分类号： C07D495/04 ,  A01N43/90 ,  A01N47/02

    摘要： Insecticidal 4-Amino--thieno[2,3-d]-pyrimidine compounds and methods of their use to control pests that damage plants and crops and parasites that harm animals. The present invention relates to new insecticidal 4-Amino--thieno[2,3-d]-pyrimidine compounds and new methods of their use. The new 4-Amino--thieno[2,3-d]-pyrimidine derivatives have formula (I), wherein X, R
    1 , R
    2 , R
    3 and A are defined as in the description. The invention relates also to their enantiomer, diastereomer or agriculturally or veterinary acceptable salt thereof. The invention relates also to agricultural and veterinary compositions comprising such compounds. The invention relates further also to different insecticidal methods applying such compounds and compositions.

    TOPICAL COMPOSITIONS COMPRISING FIPRONIL AND PERMETHRIN AND METHODS OF USE
    7.
    发明公开
    TOPICAL COMPOSITIONS COMPRISING FIPRONIL AND PERMETHRIN AND METHODS OF USE 审中-公开
    TOPISCHE ZUSAMMENSETZUNGEN MIT FIPRONIL UND VON PERMETHRIN UND VERWENDUNGSVERFAHREN

    公开(公告)号：EP2816898A1

    公开(公告)日：2014-12-31

    申请号：EP13707523.0

    申请日：2013-02-22

    申请人： Merial Limited

    发明人： SOLL, Mark, David ,  PATE, James ,  BAKER, Lisa, A.

    IPC分类号： A01N43/56 ,  A01N53/00 ,  A61K31/22 ,  A61K31/415 ,  A61K47/14 ,  A61K47/20 ,  A61P33/00

    摘要： The subject matter disclosed herein is directed to stable, highly-effective topical formulations comprising permethrin, fipronil and a solvent system that is sufficient to solubilize these two active ingredients and limit degradation of fipronil to its sulfone, and their uses in topical applications on animals and the environment. Useful formulations comprise from about 30% to about 55% (w/w) permethrin and about 2 to 15% (w/w) fipronil and a solvent system that comprises N-methyl pyrrolidone and a glycol, glycol ether, glycol ester, fatty acid ester or neutral oil, wherein the N-methyl pyrrolidone and glycol, glycol ether, glycol ester, fatty acid ester or neutral oil are present in a weight:weight ratio of from about 1:2.0 to about 1:3.5, glycol, glycol ether, glycol ester, fatty acid ester or neutral oil to n-methyl pyrrolidone. These two actives when combined in the described amounts have been found to have unexpected enhanced repellent activity against stable fly. However, it is the formulations described herein that provide solvency and stability that maintain synergistic concentrations after application on an animal.

    摘要翻译： 本文公开的主题涉及稳定，高效的局部制剂，其包括氯菊酯，氟虫腈和溶剂体系，其足以溶解这两种活性成分并限制氟虫腈对其砜的降解，以及它们在局部应用于动物和 环境。 有用的制剂包含约30％至约55％（w / w）氯菊酯和约2至15％（w / w）氟虫腈和包含N-甲基吡咯烷酮和二醇，二醇醚，乙二醇酯，脂肪 酸酯或中性油，其中N-甲基吡咯烷酮和二醇，二醇醚，乙二醇酯，脂肪酸酯或中性油以重量比约1:2.0至约1:3.5的比例存在，二醇，二醇 醚，乙二醇酯，脂肪酸酯或中性油加到正 - 甲基吡咯烷酮中。 已经发现当以所述量组合时，这两种活性物质具有针对稳定蝇的意想不到的增强的驱避活性。 然而，本文所述的制剂提供在施用于动物后保持协同浓度的溶解能力和稳定性。