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    MEANS AND METHODS FOR DIAGNOSING PROSTATE CARCINOMAS
    2.
    发明公开
    MEANS AND METHODS FOR DIAGNOSING PROSTATE CARCINOMAS 有权
    方法前列腺癌的诊断

    公开(公告)号：EP2438445A1

    公开(公告)日：2012-04-11

    申请号：EP10724454.3

    申请日：2010-06-02

    申请人： Metanomics Health GmbH ,  Charité Universitätsmedizin Berlin

    发明人： KAMLAGE, Beate ,  BETHAN, Bianca ,  RESZKA, Regina ,  LEIBOLD, Edgar ,  JUNG, Klaus ,  LEIN, Michael ,  KRISTIANSEN, Glen

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57484 ,  G01N33/57434

    摘要： The present invention relates to a method, preferably an ex vivo method, for diagnosing prostate carcinomas and/or predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from prostate carcinomas or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby prostate carcinomas or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metaboiite and the use of said at least one metabolite for the manufacture of diagnostic means for or for diagnosing prostate carcinomas. Finally, the present invention pertains to a method for identifying prostate carcinoma-related metabolites.

    MEANS AND METHODS FOR ASSESSING A QUALITY OF A BIOLOGICAL SAMPLE
    7.
    发明公开
    MEANS AND METHODS FOR ASSESSING A QUALITY OF A BIOLOGICAL SAMPLE 审中-公开
    评估生物样本质量的手段和方法

    公开(公告)号：EP3175379A1

    公开(公告)日：2017-06-07

    申请号：EP15741182.8

    申请日：2015-07-22

    申请人： metanomics Health GmbH

    发明人： KAMLAGE, Beate ,  SCHMITZ, Oliver ,  PETER, Erik

    IPC分类号： G06F19/00

    CPC分类号： G06F19/24 ,  G06F19/707

    摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention relates to a method for assessing a quality of a biological sample comprising the steps of: (a) providing a table comprising a number of entries, wherein each entry comprises a compound, at least one parameter, and a scoring factor, wherein, in case the compound is a natural compound it refers to an analyte, or in case the compound is an artificial compound it refers to a ratio of two analytes, wherein the at least one parameter is related to the compound, wherein the parameter related to the analyte is derived from at least one recorded value for the analyte while the parameter related to the ratio of the two analytes is derived from a ratio of at least one recorded value of the two analytes, and wherein the scoring factor is related to the compound; (b) determining for each of the compounds in the table a compound quality score, wherein the compound quality score is determined by taking a multiple value of the scoring factor related to the compound, wherein, depending on the actual value of the at least one parameter related to the compound, the multiple value is selected, wherein the multiple value comprises an integral number or a decimal number by which the scoring factor related to the compound is multiplied; (c) deriving at least one sample quality score by summing up the compound quality scores for the compounds in the table as determined in step (b); and (d) comparing the at least one sample quality score as derived in step (c) with at least one reference quality score, by which comparison the quality of the sample is assessed. The invention further relates to tools for performing the mentioned method, such as a device and a kit, as well as a use of components or a detection agent therefore for assessing the quality of a biological sample. The invention particularly provides for, preferably automatically, identifying a correct sample type and, concurrently, assessing the sample quality, in particular, with respect to its preanalytical phase.

    摘要翻译： 本发明涉及诊断方法领域。 具体而言，本发明涉及评估生物样品质量的方法，其包括以下步骤：（a）提供包含多个条目的表格，其中每个条目包含化合物，至少一个参数和评分因子 其中，如果所述化合物是天然化合物，则表示分析物，或者在所述化合物是人造化合物的情况下，它是指两种分析物的比率，其中所述至少一种参数与所述化合物有关，其中所述参数 与分析物有关的分析物来源于分析物的至少一个记录值，而与两种分析物的比率有关的参数是来自两种分析物的至少一个记录值的比率，并且其中评分因子与 该化合物; （b）针对表中的每种化合物确定化合物质量分数，其中通过取与化合物有关的评分因子的倍数值来确定化合物质量分数，其中取决于至少一种化合物的实际值 与所述化合物有关的参数，选择所述倍数值，其中所述倍数值包括与所述化合物相关的评分因子相乘的整数或十进制数; （c）通过对步骤（b）中测定的表中化合物的化合物质量分数进行求和得出至少一个样品质量分数; 和（d）将步骤（c）中导出的至少一个样品质量分数与至少一个参考质量分数进行比较，通过该比较评估样品的质量。 本发明进一步涉及用于执行所述方法的工具，例如装置和试剂盒，以及因此用于评估生物样品的质量的组分或检测剂的用途。 本发明特别优选自动地提供了识别正确的样本类型并且同时评估样本质量，特别是关于其分析前阶段。

    METHODS FOR DIAGNOSING PANCREATIC CANCER
    9.
    发明公开
    METHODS FOR DIAGNOSING PANCREATIC CANCER 审中-公开

    公开(公告)号：EP3502699A1

    公开(公告)日：2019-06-26

    申请号：EP17209024.3

    申请日：2017-12-20

    申请人： metanomics Health GmbH ,  Universitätsmedizin Greifswald

    发明人： KAMLAGE, Beate ,  CHRISTIANSEN, Nicole ,  SCHATZ, Philipp ,  PILARSKY, Christian ,  GRUETZMANN, Robert ,  BAHRA, Marcus ,  MAYERLE, Julia ,  LERCH, Markus ,  CHROMIK, Ansgar Michael

    IPC分类号： G01N33/574 ,  G01N33/68

    摘要： The present invention relates to a method for diagnosing pancreatic cancer in a subject suspected to suffer from pancreatic cancer comprising the steps of: (a) determining in a sample of said subject the value of (i) at least one biomarker of the categories carnitines, amino acids, and mitochondrial energy metabolites, and (ii) a first and a second sphingolipid, wherein the fatty acid residue of the first sphingolipid is at least four carbon atoms longer than the fatty acid residue of the second sphingolipid, and wherein the sphingosine backbone of the first sphingolipid and the second sphingolipid are identical; and (b) comparing the values of the biomarkers with references, whereby pancreatic cancer is diagnosed; and to a method for identifying whether a subject is in need of a pancreatic cancer therapy related thereto. The present invention further relates to a device for diagnosing pancreatic cancer in a sample of a subject comprising (a) an analyzing unit for the sample of the subject comprising a detector for the amounts of at least one biomarker each of the categories carnitines, amino acids, energy metabolites, and sphingolipids; said detector allowing for the determination of the amounts of the biomarkers of the said group of biomarkers in the sample; and operatively linked thereto, (b) an evaluation unit comprising a data processing unit and a data base, said data base comprising a stored reference and said data processing unit having tangibly embedded an algorithm for carrying out a comparison of the amounts of the biomarkers of the group of biomarkers determined by the analyzing unit and the stored reference and for generating an output information based on which the diagnosis can be established. Further, the present invention relates to a data collection and too a use related to the aforesaid subject matter.