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1.发明公开NANOPARTICLES COMPRISING ANTIGENS AND ADJUVANTS AND IMMUNOGENIC STRUCTURE 有权NANOPARTIKEL MIT ANTIGENEN UND ADJUVANTEN，DIE T HELFERZELLEN AKTIVIERENKÖNNEN
公开(公告)号：EP1793863A2
公开(公告)日：2007-06-13
申请号：EP05788525.3
申请日：2005-09-30
发明人： HIMMLER, Gottfried , MUDDE, G., C. , KIRCHEIS, Ralf , RADEMACHER, T. Midatech Limited , PENADES ULLATE, Soledad , MARTIN LOMAS, Manuel , DE PAZ CARRERA, Jose Luis , OJEDA MARTINEZ DE CASTILLA, Rafael , BARRIENTES, Africa Garcia
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K39/0011 , A61K39/39 , A61K47/646 , A61K47/6923 , A61K47/6929 , A61K2039/55555 , A61K2039/6037 , A61K2039/625 , A61K2039/645 , Y02A50/412
摘要： Nanoparticles comprising adjuvants and antigens, such as tumor and pathogen antigens, are disclosed and their use in a range of applications such as for the treatment of cancer and infectious diseases. Immunogenic structures based on nanoparticles or antibodies with carbohydrate ligands, and their use for therapeutic and prophylactic purposes, and for the isolation and detection of antibodies directed against the carbohydrate structures.
摘要翻译： 公开了包含佐剂和抗原的纳米颗粒，例如肿瘤和病原体抗原，并且其在一系列应用中的用途，例如用于治疗癌症和感染性疾病。 基于具有碳水化合物配体的纳米颗粒或抗体的免疫原性结构及其用于治疗和预防目的，以及用于分离和检测针对碳水化合物结构的抗体。
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2.发明公开
公开(公告)号：EP1370289A2
公开(公告)日：2003-12-17
申请号：EP02706509.3
申请日：2002-03-20
发明人： HIMMLER, Gottfried , LOIBNER, Hans , ECKERT, Helmut , DOBLHOFF-DIER, Otto , KIRCHEIS, Ralf , SCHUSTER, Manfred , WASSERBAUER, Erich , WAXENECKER, Günter
IPC分类号： A61K39/395 , A61K39/39 , A61P37/00
CPC分类号： C07K16/065 , A61K2039/505 , C07K16/06 , C07K16/42
摘要： The invention relates to a method for producing a vaccine, which contains autologous antibodies, characterized by the following steps: preparing a liquid that contains antibodies from a body fluid containing autologous antibodies or from autologous cell preparations or tissue preparations; treating the liquid that contains antibodies with a solid support, on which ligands are immobilized that bond to a defined group of antibodies, with the stipulation that the ligands used are not antibodies or fragments thereof with the same idiotype, directed against tumor-associated antigens; obtaining the antibodies that bond to the ligands, and; processing the obtained antibodies to form an autologous vaccine, which contains an efficient amount of antibodies ranging from several micrograms to one gram.
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公开(公告)号：EP1503799A2
公开(公告)日：2005-02-09
申请号：EP03726990.9
申请日：2003-05-15
发明人： LOIBNER, Hans , WAXENECKER, Günter , HIMMLER, Gottfried , ECKERT, Helmut , SCHUSTER, Manfred , KIRCHEIS, Ralf
IPC分类号： A61K47/48
CPC分类号： A61K39/0011 , A61K47/68 , A61K2039/6056 , C07K16/30 , C07K16/4266
摘要： The invention relates to an immunogenic antibody which comprises at least two different epitopes of a tumor-associated antigen.
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4.发明授权NANOPARTICLES COMPRISING ANTIGENS AND ADJUVANTS CAPABLE OF STIMULATING T HELPER CELLS 有权抗原及佐剂纳米颗粒，辅助性T细胞可激活
公开(公告)号：EP1793863B1
公开(公告)日：2017-04-12
申请号：EP05788525.3
申请日：2005-09-30
申请人： Midatech Ltd.
发明人： HIMMLER, Gottfried , MUDDE, G., C. , KIRCHEIS, Ralf , RADEMACHER, T. Midatech Limited , PENADES ULLATE, Soledad , MARTIN LOMAS, Manuel , DE PAZ CARRERA, Jose Luis , OJEDA MARTINEZ DE CASTILLA, Rafael , BARRIENTES, Africa Garcia
IPC分类号： A61K47/69
CPC分类号： B82Y5/00 , A61K39/0011 , A61K39/39 , A61K47/646 , A61K47/6923 , A61K47/6929 , A61K2039/55555 , A61K2039/6037 , A61K2039/625 , A61K2039/645 , Y02A50/412
摘要： Nanoparticles comprising adjuvants and antigens, such as tumor and pathogen antigens, are disclosed and their use in a range of applications such as for the treatment of cancer and infectious diseases. Immunogenic structures based on nanoparticles or antibodies with carbohydrate ligands, and their use for therapeutic and prophylactic purposes, and for the isolation and detection of antibodies directed against the carbohydrate structures.
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