公开(公告)号：EP4427693A3

公开(公告)日：2024-10-16

申请号：EP24190953.0

申请日：2020-09-01

申请人： Mirai Medical Limited

发明人： SODEN, Declan ,  FORDE, Colin ,  KINSELLA, Sean ,  MOORE, Tony

IPC分类号： A61B18/12 ,  A61N1/32 ,  C12M1/42 ,  A61B18/14 ,  A61B18/00

摘要： An electroporation apparatus comprises a plurality of electroporation probe (26) terminals (27) and a transformer (6) for providing stepped-up voltage. Also, there is a switching circuit (7) with switches (24, 25) for linking high voltage and low voltage or ground levels to the probe terminals (26). A controller (2, 4, 5) configured to control said switches according to a control scheme to deliver pulses to the probe terminals (27), and in which said pulses are delivered to groups of at least two probe electrode terminals for probe electrodes which are spaced apart. The controller maps data defining relative physical positions of probe terminals (P1-P7) to be connected to the terminals (27) and directs pulses for applying voltages across space bounded by the probe electrodes.

公开(公告)号：EP4230718A3

公开(公告)日：2023-10-18

申请号：EP23185028.0

申请日：2020-09-01

申请人： Mirai Medical Limited

发明人： SODEN, Declan ,  FORDE, Colin ,  KINSELLA, Sean ,  MOORE, Tony

IPC分类号： A61B18/12 ,  A61N1/32 ,  C12M1/42 ,  A61B18/14 ,  A61B18/00

摘要： An electroporation apparatus has an electroporation probe (26) terminals (27) for linking with electrodes. A foam is injected at the treatment site to displace blood rather than mixing with it, increasing the contact time of a higher concentration of active agent with the tissue and thus resulting in greater efficacy. With foam solutions, a lower concentration of agent can be used to obtain the same therapeutic effect as in their liquid counterpart, reducing the prevalence of side effects associated with higher concentrations. A foam solution compared to an equivalent liquid solution enables more efficient cell electroporation particularly where bipolar pulses have been employed by mitigating an increase in tissue conductivity as would normally be observed with a comparable liquid solution. A more efficient cell permeabilisation would result in better results where electroporation is being delivered alone or as a tool to aid in the uptake of molecules into the cell.

公开(公告)号：EP4427693A2

公开(公告)日：2024-09-11

申请号：EP24190953.0

申请日：2020-09-01

申请人： Mirai Medical Limited

发明人： SODEN, Declan ,  FORDE, Colin ,  KINSELLA, Sean ,  MOORE, Tony

IPC分类号： A61B18/14

CPC分类号： A61N1/327 ,  A61B2018/0061320130101 ,  A61B18/1206 ,  C12M35/02 ,  A61B2018/0011320130101 ,  A61B2018/001620130101 ,  A61B2018/0076720130101 ,  A61B2018/12420130101 ,  A61B2018/14320130101 ,  A61B18/1477 ,  A61B2018/0087520130101

摘要： An electroporation apparatus comprises a plurality of electroporation probe (26) terminals (27) and a transformer (6) for providing stepped-up voltage. Also, there is a switching circuit (7) with switches (24, 25) for linking high voltage and low voltage or ground levels to the probe terminals (26). A controller (2, 4, 5) configured to control said switches according to a control scheme to deliver pulses to the probe terminals (27), and in which said pulses are delivered to groups of at least two probe electrode terminals for probe electrodes which are spaced apart. The controller maps data defining relative physical positions of probe terminals (P1-P7) to be connected to the terminals (27) and directs pulses for applying voltages across space bounded by the probe electrodes.

公开(公告)号：EP4025144A1

公开(公告)日：2022-07-13

申请号：EP20767504.2

申请日：2020-09-01

申请人： Mirai Medical Limited

发明人： SODEN, Declan ,  FORDE, Colin ,  KINSELLA, Sean ,  MOORE, Tony

IPC分类号： A61B18/12 ,  A61N1/32 ,  C12M1/42 ,  A61B18/00

公开(公告)号：EP4230718A2

公开(公告)日：2023-08-23

申请号：EP23185028.0

申请日：2020-09-01

申请人： Mirai Medical Limited

发明人： SODEN, Declan ,  FORDE, Colin ,  KINSELLA, Sean ,  MOORE, Tony

IPC分类号： C12M1/42

摘要： An electroporation apparatus has an electroporation probe (26) terminals (27) for linking with electrodes. A foam is injected at the treatment site to displace blood rather than mixing with it, increasing the contact time of a higher concentration of active agent with the tissue and thus resulting in greater efficacy. With foam solutions, a lower concentration of agent can be used to obtain the same therapeutic effect as in their liquid counterpart, reducing the prevalence of side effects associated with higher concentrations. A foam solution compared to an equivalent liquid solution enables more efficient cell electroporation particularly where bipolar pulses have been employed by mitigating an increase in tissue conductivity as would normally be observed with a comparable liquid solution. A more efficient cell permeabilisation would result in better results where electroporation is being delivered alone or as a tool to aid in the uptake of molecules into the cell.