公开(公告)号：EP2265220A1

公开(公告)日：2010-12-29

申请号：EP09717359.5

申请日：2009-03-05

申请人： Musculoskeletal Transplant Foundation

发明人： TRUNCALE, Katherine, G. ,  SEMLER, Eric, J. ,  GERTZMAN, Arthur, A. ,  SUNWOO, Moon, Hae ,  TOMFORD, William, W. ,  SHIKHANOVICH, Roman ,  CALLAHAN, Alex, B. ,  YANNARIELLO-BROWN, Judith, I. ,  HUANG, Yen-chen ,  JACOBS, Morris, L. ,  MUNSON, John, C.

IPC分类号： A61F2/28 ,  A61F2/30

CPC分类号： A61F2/30756 ,  A61B17/00491 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/3859 ,  A61F2/3872 ,  A61F2002/2817 ,  A61F2002/2839 ,  A61F2002/2842 ,  A61F2002/30057 ,  A61F2002/30059 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30227 ,  A61F2002/30233 ,  A61F2002/30235 ,  A61F2002/30327 ,  A61F2002/30331 ,  A61F2002/30354 ,  A61F2002/30387 ,  A61F2002/30448 ,  A61F2002/30459 ,  A61F2002/30461 ,  A61F2002/30492 ,  A61F2002/30604 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30772 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30795 ,  A61F2002/3085 ,  A61F2002/30932 ,  A61F2002/3096 ,  A61F2002/4635 ,  A61F2002/4646 ,  A61F2002/4649 ,  A61F2210/0004 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2230/0069 ,  A61F2250/0039 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2430/06 ,  C08L89/00

摘要： Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct (20) includes a base member (22), a cap member (30) and at least one pin (40) that secures the cap member (30) to the base member (20). The base member (22) may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member (22) includes a blind bore (23) and first and second through-going transverse bores (28, 29) in opposite sides of a wall of the base member (22). The cap member (30) includes an upper section (32) that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem (36) depending from the upper section (32) that is dimensioned to be received in and by the blind bore (23) of the base member (22). The stem (36) includes a transverse through-going bore (37), which may be aligned with the transverse through-going bores (28, 29) of the base member (22) to receive the pin (40) therein when the construct (20) has been assembled. The cap member (30) is at least partially formed of demineralized allograft cancellous bone, into which a mixture containing lyophilized, freeze-milled allograft cartilage particles may be infused for the repair of articular cartilage defects. The cartilage particles have a size within a range of from about 10 microns to about 210 microns.

公开(公告)号：EP1618178B1

公开(公告)日：2008-07-16

申请号：EP04749924.9

申请日：2004-04-21

申请人： Musculoskeletal Transplant Foundation

发明人： TRUNCALE, Katherine, A. ,  SUNWOO, Moon Hae ,  GERTZMAN, Arthur, A. ,  TOMFORD, William, W.

IPC分类号： A61K35/32

CPC分类号： A61F2/28 ,  A61B17/00491 ,  A61F2/30744 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/3859 ,  A61F2002/2817 ,  A61F2002/2867 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30759 ,  A61F2002/30764 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2310/00365 ,  A61F2310/00383 ,  A61K35/28 ,  A61K35/32 ,  A61K38/18 ,  A61K38/28 ,  A61L27/20 ,  A61L27/24 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/3817 ,  A61L27/3821 ,  A61L27/3834 ,  A61L27/3852 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  A61L2430/06 ,  A61K2300/00 ,  C08L5/08

摘要： The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers with allogenic chondrocytes or bone marrow cells in an amount exceeding the natural occurrence of same in hyaline cartilage and adding a cell growth additive.

公开(公告)号：EP1618178A2

公开(公告)日：2006-01-25

申请号：EP04749924.9

申请日：2004-04-21

申请人： Musculoskeletal Transplant Foundation ,  Gomes, Katherine, A. ,  Sunwoo, Moon Hae ,  Gertzman, Arthur, A. ,  Tomford, William, W.

发明人： GOMES, Katherine, A. ,  SUNWOO, Moon Hae ,  GERTZMAN, Arthur, A. ,  TOMFORD, William, W.

IPC分类号： C12N1/00

CPC分类号： A61F2/28 ,  A61B17/00491 ,  A61F2/30744 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/3859 ,  A61F2002/2817 ,  A61F2002/2867 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30759 ,  A61F2002/30764 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2310/00365 ,  A61F2310/00383 ,  A61K35/28 ,  A61K35/32 ,  A61K38/18 ,  A61K38/28 ,  A61L27/20 ,  A61L27/24 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/3817 ,  A61L27/3821 ,  A61L27/3834 ,  A61L27/3852 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  A61L2430/06 ,  A61K2300/00 ,  C08L5/08

摘要： The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers with allogenic chondrocytes or bone marrow cells in an amount exceeding the natural occurrence of same in hyaline cartilage and adding a cell growth additive.